Possible modulatory effect of melatonin on chemotherapy-induced neuropathy / (Record no. 174832)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05949namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251023114746.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251014s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.78 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.78 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.09.Ph.D.2025.En.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Engie Samir El-Sawaf, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Possible modulatory effect of melatonin on chemotherapy-induced neuropathy / |
| Statement of responsibility, etc. | by Engie Samir El-Sawaf ; Supervision Dr. Hala Fahmy, Dr. Hanan El-Abhar, Dr. Ahmed Fathi, Dr. Nabila El-Maraghy. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير المعدل الممكن للميلاتونين في تلف الأعصاب المحدث بالعلاج الكيماوي |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 103 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 91-103. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Vincristine (VCR), an anti-tubulin chemotherapy agent, is known to cause peripheral and central nerve damage, causing severe chemotherapy-induced peripheral neuropathy (CIPN). Although melatonin has been recently recognized for its potential anti-neuropathic effects, its efficacy in countering VCR-induced neuropathy remains unclear. This study examines the neuroprotective potential of melatonin against VCR-induced neuropathy using a rat model. Neuropathic pain was induced through 10 VCR injections (0.1 mg/kg/day i.p.), administered in two five-day cycles with a two-day break. Melatonin treatment started two days before VCR administration and continued daily throughout the experiment. Rats were assigned to five groups: control, VCR, and three melatonin-treated groups receiving VCR with melatonin (5, 10, or 20 mg/kg/day i.p.). We assessed mechanical (von-Frey and Randall-Selitto tests) and thermal (hot-plate and tail-flick tests) hyperalgesia, motor coordination (rotarod test), and sciatic nerve conduction velocity (NCV). Changes in body weight, spinal cord histopathology (H&E), and proinflammatory markers, including tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and interleukin (IL-6), reactive astrocytes (glial fibrillary acidic protein; GFAP) and microglial cells (ionized calcium-binding adaptor molecule-1; IBA-1) were also assessed, as well as spinal cord degeneration (Nissl stain) and demyelination (luxol fact blue; LFB stain and myelin basic protein; MBP). Finally, the effect of melatonin on the cytotoxic activity of VCR against EL4 lymphoma cells was assessed using an MTT assay. Our results indicated that melatonin coadministration with VCR preserved spinal cord architecture, elevated nociceptive thresholds, improved motor coordination, enhanced NCV, and maintained normal body weight gain. Melatonin also reduced inflammation, decreased reactive astrocytes and microglia, and prevented neurodegeneration and demyelination in the spinal cord. Importantly, melatonin did not affect VCR’s cytotoxic activity in cancer cells. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | يعتبر التهاب الأعصاب الطرفي من الأعراض الجانبية الأكثر شيوعاً للعلاج الكيماوي و يُعد عقار الفينكريستين أحد العلاجات الكيماوية الأكثر شيوعاً ويستعمل في علاج العديد من أنواع السرطان، ولكنه يتسبب في التهاب شديد في الأعصاب الطرفية والمركزية. هذا الاعتلال العصبي قد يُجبر المرضى على تقليل الجرعة أو إيقاف العلاج تماماً بسبب شدة الألم. حتى الآن، لا يوجد علاج فعال للحد من هذا النوع من التهاب الأعصاب المصاحب للعلاج الكيماوي، مما يحد من فعالية الفينكريستين في القضاء على الأورام السرطانية. <br/>تشمل آليات الضرر العصبي الناتج عن العلاج الكيماوي العديد من المسارات التي تتكامل لتؤدي إلى التهاب الأعصاب وموت الخلايا المبرمج، بالإضافة إلى تليف الأعصاب. وعلى الرغم من وجود بعض العلاجات التي تُستخدم للتخفيف من أعراض التهاب الأعصاب الطرفية، إلا أن فعالية هذه الخيارات محدودة للغاية.<br/>يُعرف الميلاتونين بمدى واسع من النشاطات البيولوجية، بما في ذلك تنظيم النوم والساعة البيولوجية، والحد من عجز الخلايا. وقد أظهرت الأبحاث السابقة أهمية الميلاتونين في حماية الأعصاب، ولكن قدرته الكاملة على تخفيف التهاب الأعصاب الناجم عن استخدام عقار الفينكريستين لم تُستكشف بشكل كامل بعد. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drugs that affect the nerves |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الأدوية المؤثرة علي الأعصاب |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vincristine |
| -- | Melatonin |
| -- | Neuroprotection |
| -- | Chemotherapy Neurotoxicity; |
| -- | Central pain sensitization; |
| -- | Behavioral tests |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan El-Abhar |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Fathi |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nabila El-Maraghy |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Hala Fahmy |
| -- | Hanan El-Abhar |
| -- | Ahmed Fathi |
| -- | Nabila El-Maraghy |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmacology and Toxicology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 14.10.2025 | 92167 | Cai01.08.09.Ph.D.2025.En.P | 01010110092167000 | 14.10.2025 | 14.10.2025 | Thesis |