Role of inter-ictal non contrast magnetic resonance perfusion imaging using 3D pseudo-continuous arterial spin labelling in the assessment of epilepsy / (Record no. 174847)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06529namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251014120223.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251014s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.07548 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.07548 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.31.M.Sc.2024.Yo.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Youssef Amr Osama Azab, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Role of inter-ictal non contrast magnetic resonance perfusion imaging using 3D pseudo-continuous arterial spin labelling in the assessment of epilepsy / |
| Statement of responsibility, etc. | by Youssef Amr Osama Azab ; Supervisors Dr. Ayman Abdelhamid El Basmi, Dr. Shady Mohamed Tarek Gamal. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دورالرنين المغناطيسي الاروائي بدون صبغة عن طريق الوسم ثلاثى الابعاد شبه المستمر للبروتونات داخل الشرايين المجرى بين نوبات الصرع في تقييم الصرع |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 89 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 79-89. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Epilepsy is the 2nd most common neurological disorder with 52 million patients suffering from its morbidities worldwide. Epilepsy is a complex condition with a multitude of causes that necessitate extensive laboratory, neurophysiologic and imaging investigations. Most of epileptic patients (about 80%) live in low-income countries with poor health sector resources. Approximately 33% of epileptic patients are drug resistant and referring to surgical ablation of epileptic focus can be the treatment of choice. Structural MRI studies fail to detect an ablatable/resectable focus in about 40% of those patients and standard electro-encephalogram procedure (EEG) eventually fails to localize or capture this epileptogenic focus. Non-contrast assessment of cerebral blood flow using 3D-pseduo continuous arterial spin labelling (3D-pCASL) was reported as a highly cost effective and safe procedure with diagnostic capabilities comparable to both FDG18-PET and H2O15-PET studies in localizing epileptic foci and mapping out epileptic networks in an ultra-short examination time and associated ultra-high structural resolution of simultaneously acquired MRI study compared to longer EEG examination time and poor spatial resolution.<br/>Objectives and aim of work: To assess the sensitivity of inter-ictal 3D-pCASL in detection and lateralization of epileptic foci in comparison to the widely available, routinely performed, standard EEG procedure.<br/>Methods: The study was carried out on 60 epileptic patients. After clinical evaluation and performing EEG, structural MRI as well as 3D pCASL were carried out to detect any structural abnormality and assess mesiotemporal lobe CBF values respectively. Pearson correlation test was used to assess correlations between the EEG and 3D PCASL results to calculate the concordance between them in addition to comparing their sensitivity. ROC analysis was conducted to assess the cut-off percentage difference between CBF values of both mesiotemporal lobes at which lateralization of the epileptogenic focus can be determined. Level of agreement between diagnostic tests was conducted using Kappa test. <br/>Results: pCASL has shown to be a reliable method for lateralizing epileptogenic foci when compared to routine EEG, being more sensitive and more accurate in terms of localization.<br/>Conclusion: MRI 3D PCASL is a promising noninvasive modality in evaluation of the epileptogenic focus lateralization. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | الصرع هو اضطراب عصبي يتميز بنوبات متكررة، ويؤثر على الملايين في جميع أنحاء العالم. في حين أن الأدوية تسيطر بشكل فعال على النوبات لدى العديد من الأفراد، فإن ما يقرب من 33٪ من المرضى يعانون من الصرع المقاوم للأدوية. في هذه الحالات، يصبح التدخل الجراحي لإزالة بؤرة الصرع (منطقة الدماغ المسؤولة عن بدء النوبات) خيارًا علاجيًا قابلاً للتطبيق. <br/>ومع ذلك، فإن تحديد هذه المنطقة المسببة للصرع يمثل تحديًا كبيرًا. إن أدوات التشخيص التقليدية، مثل التصوير بالرنين المغناطيسي البنيوي (الذي يفحص تشريح الدماغ) وتخطيط كهربية الدماغ (الذي يسجل النشاط الكهربائي للدماغ)، غالباً ما تكون قاصرة، فتفشل في تحديد الموقع الدقيق للاستئصال لدى 30% إلى 40% من مرضى الصرع المقاوم للأدوية.<br/>ويؤكد هذا القيد الحاجة إلى أساليب تحقيق أكثر حساسية. يتضمن أحد الأساليب الواعدة التصوير بالرنين المغناطيسي للتروية غير المتباينة باستخدام طريقة محددة تسمى وضع العلامات على الدوران الشرياني المستمر الزائف ثلاثي الأبعاد (pCASL). تقيس تقنية التصوير المتقدمة هذه تدفق الدم في المخ، والذي يمكن أن يظهر تغيرات مميزة داخل المنطقة المسببة للصرع. أظهرت الدراسة الحساسية العالية لـ pCASL في تحديد جهة الفص الدماغي الذي يحتوي على بؤرة الصرع الأولية، مما قد يوفر رؤى قيمة للتخطيط الجراحي وربما تحسين معدلات نجاح جراحة الصرع. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | magnetic resonance |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الرنين المغناطيسي |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | epilepsy |
| -- | EEG |
| -- | 3D PCASL |
| -- | MRI perfusion |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman Abdelhamid El Basmi |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shady Mohamed Tarek Gamal |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Ayman Abdelhamid El Basmi |
| -- | Shady Mohamed Tarek Gamal |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Diagnostic and Interventional Radiology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 14.10.2025 | 92400 | Cai01.11.31.M.Sc.2024.Yo.R | 01010110092400000 | 14.10.2025 | 14.10.2025 | Thesis |