Association between hypothyroidism (overt and subclinical) and non-alcoholic fatty liver disease and its severity in Egyptian population / (Record no. 174854)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 07106namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251014124356.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251014s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.444 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.444 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.18.Ph.D.2025.Mi.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mirette Makram Bekhit, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Association between hypothyroidism (overt and subclinical) and non-alcoholic fatty liver disease and its severity in Egyptian population / |
| Statement of responsibility, etc. | by Mirette Makram Bekhit ; Supervisors Dr. Amany Abdelmaksoud Sholkamy, Dr.Shrook Mohammed Mousa, Dr.Samar Mohamed Amin, Dr. Noha Wael Arafat. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الارتباط بين قصور الغدة الدرقية (الصريح ودون الإكلينيكي) ومرض الكبد الدهني غير الكحولي وشدته فى السكان المصريين |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 135 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 97-135. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) affects 25% of the global adult population and is the leading cause of chronic liver disease with the risk of hepatocellular carcinoma. Hypothyroidism is a common endocrine disorder that may influence MAFLD development.<br/>Aim of the Work: To determine the relationship between hypothyroidism and nonalcoholic fatty liver disease and its severity in Egyptian population.<br/>Patients and Methods: This case-control study involved 144 Egyptian adults, including 48 overt hypothyroid patients, 48 subclinical hypothyroid patients, and 48 controls after exclusion of patients with history of alcohol consumption, diabetes mellitus or prediabetes and any causes of chronic liver diseases such as chronic viral hepatitis B or C. All participants were assessed for MAFLD using ultrasound and MRI and hepatic fat percentage was calculated to assess the severity of MAFLD.<br/>Results: 34 of the 48 overt hypothyroid,27 of the 48 subclinical hypothyroid patients and 3 of the control group were diagnosed to have MAFLD, mild steatosis was 38.2% and 63% among the overt and subclinical group respectively and moderate steatosis was 61.8% and 37 % among the overt and subclinical group respectively. The statistically significant predictors for the risk of MAFLD development were the TSH level, serum triglycerides and duration of overt and subclinical hypothyroidism (p value˂0.001). TSH correlated positively with the degree of steatosis independent of other factors (p value <0.001). TSH correlated positively with the hepatic fat percentage (p value˂0.001). Multivariate analysis showed TSH is independent risk factor for MAFLD development and severity.<br/>Conclusion: Our study establishes a significant relationship between the spectrum of hypothyroidism (both overt and subclinical) and metabolic dysfunction-associated fatty liver disease (MAFLD) in the Egyptian population. TSH level is independent risk factor for MAFLD development and severity as well. The higher the TSH, the higher risk of development of MAFLD and the higher risk of progression to advanced steatosis stages and higher fat content. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | مرض الكبد الدهني المرتبط باضطراب التمثيل الغذائي يؤثر على حوالي 25% من السكان البالغين حول العالم ويعد السبب الرئيسي لأمراض الكبد المزمنة. يتراوح من التنكس الدهني البسيط إلى التهاب الكبد الدهني الاستقلابي والتليف، مما يزيد بشكل كبير من خطر الإصابة بالسرطان وأمراض القلب والأوعية الدموية.<br/>قصور الغدة الدرقية، الذي يتميز بارتفاع مستويات هرمون الغدة الدرقية، يلعب دورًا حاسمًا في تطوير مرض الكبد الدهني المرتبط باضطراب التمثيل الغذائي. كشفت دراستنا الحالتية الضابطة التي شملت 144 بالغًا مصريًا (48 من مرضى قصور الغدة الدرقية الواضح، 48 من مرضى قصور الغدة الدرقية تحت السريري، و48 مجموعة تحكم) عن مستويات أعلى بكثير من الكوليسترول، والدهون منخفضة الكثافة، والدهون الثلاثية في مرضى قصور الغدة الدرقية.<br/>كان انتشار مرض الكبد الدهني المرتبط باضطراب التمثيل الغذائي أعلى بشكل ملحوظ بين مرضى قصور الغدة الدرقية الواضح (70.8%) وتحت السريري (56.3%) مقارنة بمجموعة التحكم (6.3%).<br/>تتوافق نتائجنا مع دراسات سابقة أكدت الدور المباشر لقصور الغدة الدرقية في تطوير مرض الكبد الدهني المرتبط باضطراب التمثيل الغذائي. ومع ذلك، أشارت بعض الدراسات إلى عدم وجود علاقة، ويرجع ذلك على الأرجح إلى اختلاف أساليب التشخيص.<br/>تشمل العوامل التنبؤية المهمة لتطور مرض الكبد الدهني المرتبط باضطراب التمثيل الغذائي مستويات هرمون الغدة الدرقية المرتفعة، والدهون الثلاثية في الدم، ومدة الإصابة بقصور الغدة الدرقية. تُشير هذه النتائج إلى أن اختلال وظيفة الغدة الدرقية يزيد من سوء مرض الكبد الدهني المرتبط باضطراب التمثيل الغذائي من خلال خلل الشحميات وتقليل مستويات هرمون الغدة الدرقية.<br/>فهم هذه العلاقات ضروري للتعرف المبكر ومنع مرض الكبد الدهني المرتبط باضطراب التمثيل الغذائي لدى مرضى قصور الغدة الدرقية. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Hypothyroidism |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | قصور الغدة الدرقية |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MAFLD |
| -- | hypothyroidism |
| -- | overt |
| -- | subclinical |
| -- | TSH |
| -- | dyslipidemia |
| -- | MRI |
| -- | steatosis |
| -- | hepatic fat content |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amany Abdelmaksoud Sholkamy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shrook Mohammed Mousa |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samar Mohamed Amin |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Wael Arafat |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Amany Abdelmaksoud Sholkamy |
| -- | Shrook Mohammed Mousa |
| -- | Samar Mohamed Amin |
| -- | Noha Wael Arafat |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Internal Medicine |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 14.10.2025 | 92403 | Cai01.11.18.Ph.D.2025.Mi.A | 01010110092403000 | 14.10.2025 | 14.10.2025 | Thesis |