Distribution of human leukocyte antigens (HLAs) and their association with different hematological disorders in Egyptian population / (Record no. 175125)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05860namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251103103821.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251021s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 611.018 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 611.018 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.21.Ph.D.2025.No.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Nourhan Hussien Mekky Mohamed, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Distribution of human leukocyte antigens (HLAs) and their association with different hematological disorders in Egyptian population / |
| Statement of responsibility, etc. | by Nourhan Hussien Mekky Mohamed ; Supervision Prof. Salwa Sabet, Dr. Heba Bassiony, Prof. Yasser El Nahass, Prof. Raafat Abd Al Fattah. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | توزيع مستضدات كرات الدم البيضاء البشرية وارتباطها بأمراض الدم المختلفة في المصريين |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 102 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 82-102. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | HLA alleles are representative of ethnicities and may play important roles in predisposition to hematological disorders. We analyzed DNA samples for HLA-A, -B, -C, -DRB1, and -DQB1 loci, from 1550 patients and 4450 potential related donors by PCR-SSO (Polymerase chain reaction sequence-specific oligonucleotides) and estimated allele frequencies in donors and patients from 1550 families who underwent bone marrow transplantation (BMT) in Egypt. We also studied the association between HLA allele frequencies and incidence of acute myeloid leukemia, acute lymphoblastic leukemia, and severe aplastic anemia. The most frequently observed HLA class I alleles were HLA- A*01:01 (16.9%), A*02:01 (16.1%), B*41:01 (8.7%), B*49:01 (7.3%), C*06:02 (25.1%), and C*07:01 (25.1%), and the most frequently observed class II alleles were HLA-DRB1*11:01 (11.8%), DRB1*03:01 (11.6%), DQB1*03:01 (27.5%), and DQB1*05:01 (18.9%). The most frequently observed haplotypes were A*33:01B*14:02DRB1*01:02 (2.35%) and A*01:01B*52:01DRB1*15:01 (2.11%). HLA-DRB1*07:01 was associated with higher AML odds (OR, 1.26; 95% CI, 1.02 ─ 1.55; p=0.030). Only HLA-B38 antigen showed a trend towards increased odds of ALL (OR, 1.52; 95% CI, 1.00 ─ 2.30; p=0.049) HLA-A*02:01, -B*14:02, and -DRB1*15:01 were associated with higher odds of SAA (A*02:01: OR, 1.35; 95% CI, 1.07 ─ 1.70; p=0.010; B*14:02: OR, 1.43; 95% CI, 1.06 ─ 1.93; p=0.020; DRB1*15:01: OR, 1.32; 95% CI, 1.07 ─ 1.64; p=0.011). This study provides estimates of HLA allele and haplotype frequencies and their association with hematological disorders in an Egyptian population. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | الأليلات HLA تمثل الأعراق وقد تلعب أدوارًا مهمة في الاستعداد للإصابة بالاضطرابات الدموية. قمنا بتحليل عينات الحمض النووي لمواقع HLA-A و -B و -C و -DRB1 و -DQB1 من 1550 مريضًا و 4450 متبرعًا محتملاً من الأقارب باستخدام تفاعل البلمرة المتسلسل الخاص بالنوكليوتيدات (PCR-SSO)، وقمنا بتقدير ترددات الأليل في المتبرعين والمرضى من 1550 عائلة خضعت لزراعة نخاع العظم (BMT) في مصر. كما درسنا العلاقة بين ترددات الأليل HLA وحدوث سرطان الدم النخاعي الحاد، وسرطان الدم الليمفاوي الحاد، وفقر الدم اللاتنسجي الحاد. كانت الأليلات الأكثر شيوعًا من فئة HLA-I هي HLA- A*01:01 (16.9%)، A*02:01 (16.1%)، B*41:01 (8.7%)، B*49:01 (7.3%)، C*06:02 (25.1%)، و C*07:01 (25.1%)، والأليلات الأكثر شيوعًا من فئة HLA-II هي HLA-DRB1*11:01 (11.8%)، DRB1*03:01 (11.6%)، DQB1*03:01 (27.5%)، و DQB1*05:01 (18.9%). كانت أكثر الأنماط الفردية شيوعًا هي A*33:01~B*14:02~DRB1*01:02 (2.35%) و A*01:01~B*52:01~DRB1*15:01 (2.11%). كان HLA-DRB1*07:01 مرتبطًا بزيادة احتمالية الإصابة بسرطان الدم النخاعي الحاد (OR، 1.26؛ 95% CI، 1.02 - 1.55؛ p=0.030). أظهر فقط مستضد HLA-B38 اتجاهًا نحو زيادة احتمالية الإصابة بسرطان الدم الليمفاوي الحاد (OR، 1.52؛ 95% CI، 1.00 - 2.30؛ p=0.049). كانت الأليلات HLA-A*02:01 و -B*14:02 و -DRB1*15:01 مرتبطة بزيادة احتمالية الإصابة بفقر الدم اللاتنسجي الحاد (A*02:01: OR، 1.35؛ 95% CI، 1.07 - 1.70؛ p=0.010؛ B*14:02: OR، 1.43؛ 95% CI، 1.06 - 1.93؛ p=0.020؛ DRB1*15:01: OR، 1.32؛ 95% CI، 1.07 - 1.64؛ p=0.011). توفر هذه الدراسة تقديرات لترددات الأليل والنمط الفردي HLA وعلاقتها بالاضطرابات الدموية في سكان مصريين. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell biology |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | علم الخلية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HLA-A |
| -- | HLA-B, |
| -- | HLA-C |
| -- | HLA-DR |
| -- | HLA-DQ |
| -- | BMT |
| -- | AML |
| -- | ALL |
| -- | SAA |
| -- | LD |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salwa sabet |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Bassiony |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yasser El-Nahass |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rafaat Abd Al-Fattah |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Salwa sabet |
| -- | Heba Bassiony |
| -- | Yasser El-Nahass |
| -- | Rafaat Abd Al-Fattah |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Zoology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 21.10.2025 | 92234 | Cai01.12.21.Ph.D.2025.No.D | 01010110092234000 | 21.10.2025 | 21.10.2025 | Thesis |