Synthesis and anticancer activity of novel fused pyrimidine derivatives / (Record no. 175212)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04857namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251026140753.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251026s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.19 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.04.Ph.D.2025.Am.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Aml El-Sayed Mghwary Mohammed, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis and anticancer activity of novel fused pyrimidine derivatives / |
| Statement of responsibility, etc. | by Aml El-Sayed Mghwary Mohammed ; Supervision Prof. Dr. Mohammed Kamal Abdelhameid, Prof. Dr. Peter Amir Halim, Prof. Dr. Rasha Ahmed Mahmoud. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشييد وتقييم النشاط المضاد للخلايا السرطانية لمشتقات البيريميدين المدمجة |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 176 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 148-167. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | This Thesis incorporates four chapters. The first chapter includes an introduction about the various methods for the synthesis of thieno[2,3-d]pyrimidine derivatives, a brief survey on programmed cell death, tyrosine kinase receptor enzymes, apoptosis, as well as the anticancer activity of thienopyrimidine-bearing derivatives. The second chapter displays the research objectives of the work, and the schemes outlined for the synthesis of the target compounds. The third chapter contributes the theoretical discussion of the experimental work, the discussion of the anticancer and enzymatic activities of the new compounds, molecular modelling study and a brief discussion of the structure-activity relationship as well. The fourth chapter comprises the experimental work demonstrating the procedures carried out for preparing the intermediates and the target compounds in details along with the physical properties of the synthesized compounds, their element analyses and spectral data are elucidated. Furthermore, it covers the in vitro anticancer and FLT-3 enzymatic activities of the newly synthesized compounds, the apoptotic activity of the most active compounds and their molecular docking study. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | تحتوي الرسالة على اربعة فصول. الفصل الاول يتضمن مقدمة حول الطرق المختلفة لتشييد مشتقات الثيينو]٢,٣-د[بيريميدين، ومقدمة موجزة عن موت الخلايا المبرمج، وإنزيمات مستقبلات التيروزين كيناز، وموت الخلايا المبرمج، بالإضافة إلى النشاط المضاد للسرطان لمشتقات الثينوبيريميدين. الفصل الثاني يعرض أهداف البحث وعرض المخططات التي توضح الطرق العملية التي صممت للحصول على هذه المركبات.<br/> الفصل الثالث يتضمن المناقشة النظرية للجزء العملى، ومناقشة الأنشطة المضادة للسرطان والأنشطة الإنزيمية للمركبات الجديدة، ودراسة النمذجة الجزيئية، ومناقشة موجزة عن علاقة تركيب المركبات بفاعليتها. الفصل الرابع يشمل الخطوات العملية التي تم تنفيذها لتحضير المركبات الوسيطة والمستهدفة بالتفصيل، بالإضافة إلى خصائص المركبات التي تم تشييدها، وتحليل العناصر والبيانات الطيفية لهذه المركبات. هذا الفصل يغطي أيضا النشاط المضاد للسرطان في المختبر وفاعلية المركبات التي تم تشييدها حديثًا ضد إنزيم FLT-3 ، ونشاط موت الخلايا المبرمج للمركبات الأكثر فاعلية ودراسة النمذجة الجزيئية لها. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmaceutical Chemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الكيمياء الصيدلية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gewald reaction |
| -- | FLT-3 |
| -- | Thieno[2,3-d]pyrimidines |
| -- | Anticancer activity |
| -- | Apoptosis |
| -- | Molecular docking |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Kamal Abdelhameid |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Peter Amir Halim |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rasha Ahmed Mahmoud |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Mohammed Kamal Abdelhameid |
| -- | Peter Amir Halim |
| -- | Rasha Ahmed Mahmoud |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmaceutical Organic Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 26.10.2025 | 92264 | Cai01.08.04.Ph.D.2025.Am.S | 01010110092264000 | 26.10.2025 | 26.10.2025 | Thesis |