Evaluation of the role fpstein‐barr virus in patients with pulmonary arterial hypertension / (Record no. 175330)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 07176namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251103160704.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251101s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.2 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.2 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.06.Ph.D.2025.Ma.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mariam Yasser Mohammed Elhalafawy, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of the role fpstein‐barr virus in patients with pulmonary arterial hypertension / |
| Statement of responsibility, etc. | by Mariam Yasser Mohammed Elhalafawy ; Supervisors Prof. Reem Ibrahim Mohamed Elkorashy, Prof. Hala Gabr Metwally, Prof. Hoda Mohamed Mahmoud Abdel-hamid, Dr. Jumana Hesham Ismail. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم دور فيروس إيبشتاين بار فى إرتفاع ضغط الشريان الرئوى |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 94 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 69-82. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: The pathophysiology of the development of PAH in CAEBV is unclear. It may be related to lymphocytic infiltration and the resultant damage to the pulmonary vascular endothelium caused by EBV infection or may occur secondary to the vascular damage caused by inflammatory reactions induced by EBV infection.<br/>Aim of work: This study’s aim was to evaluate the role of EBV infection in PAH (Idiopathic and connective tissue disease (CTD) patient). The study was done to find CAEBV infection maybe a cause or aggravating factor in pulmonary arterial hypertension patients. <br/>Patients and methods: The 42 PAH patients were selected after doing all routine investigations for pulmonary hypertension and exclusion of other causes of PAH and underwent routine right heart catheterization. The balloon tip of the Swan Ganz Catheter was transferred in Trypsin-EDTA that was added to the transport solution to the clinical pathology lab where tissue culture took place. 10 ml of blood was withdrawn from the patients and the 36 healthy controls as well for blood EBV PCR and Serology testing (IgG and IgM).<br/>Results: There was significant increase in cases than controls regarding the presence of EBV Serum IgM. There was also significant increase in cases than controls regarding the presence of CAEBV infection. Regarding the hemodynamics in the right heart catheter (RHC), there was significant association between degree of dysplasia in endothelial cell culture and mean right atrial pressure (mRAP), pulmonary vascular resistance (PVR) and pulmonary vascular resistance index (PVRI) of idiopathic cases. Otherwise, the results showed no statical significance. <br/>Conclusion: It was concluded that there was significant increase in cases than controls regarding the presence of CAEBV infection. There was also a significant increase in cases than controls regarding the presence EBV Serum IgM. Never the less, there was no significant difference between cases and control regarding the median (IQR) of EBV Serum IgG, IgM and Blood PCR. Nor was there a significant statistical result regarding the presence of the EBV in the endothelial cells of the pulmonary artery with the presence of dysplasia. Given the previous results and reviewing the literature, we cannot establish a direct role for CAEBV in patients with PAH |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | ارتفاع ضغط الشريان الرئوي هو اضطراب مزمن ومتقدم يتميز باعتلال الأوعية الدموية التكاثري في الشرايين الرئوية، مما يؤدي إلى تكاثر الخلايا البطانية والعضلات الملساء واختلال وظائفها، والالتهابات والجلطات. تزيد هذه التغييرات من مقاومة الأوعية الدموية الرئوية وضغط الشريان الرئوي اللاحق.<br/>عادةً ما يتم تعريف مرض فيروس إبشتاين بار النشط المزمن (CAEBV) بأنه مرض مزمن يستمر لمدة 6 أشهر على الأقل، مع زيادة مستوى فيروس إبشتاين بار في الأنسجة أو الدم. يرتبط عدوى فيروس إبشتاين بار بمجموعة متنوعة من أمراض المناعة الذاتية و الاورام.<br/>هناك آليتان مرضيتان محتملتان يتسبب فيهما فيروس إبشتاين بار في ارتفاع ضغط الشريان الرئوي، إحداهما أن فيروس إبشتاين بار يسبب التهاب الشرايين الرئوي مما يؤدي إلى إعادة تشكيل هيكل الشريان الرئوي، والأخرى هي أن العدوى المزمنة بفيروس إبشتاين بار تسبب مستويات عالية من السيتوكينات الالتهابية التي تسبب تغيرًا التهابيًا في الشريان الرئوي.<br/>هدفت دراستنا إلى تقييم دور فيروس إبشتاين بار النشط المزمن في مرضى ارتفاع ضغط الشريان الرئوي. سواء كان CAEBV سببًا أو ارتباطًا مشتركًا أو عاملًا مفاقمًا.<br/>أجريت دراستنا في مستشفيات قصر العيني، قسم أمراض الصدر، وحدة أمراض الأوعية الدموية الرئوية، وشملت 42 مريضًا بارتفاع ضغط الشريان الرئوي و36 من الأشخاص الأصحاء العينة الضابطة، الذين تطابقوا في العمر والجنس.<br/>تتلخص الدراسة إلى وجود زيادة كبيرة في الحالات مقارنة بالضوابط فيما يتعلق بوجود عدوى CAEBV.لم يكن هناك فرق ذو دلالة احصائية بين الحالات والضوابط فيما يتعلق بالمدى الربيعي (IQR) لـ الاجسام المضادة المناعية من نوع ال IgG و IgM و تحاليل تفاعل البوليميرازالمتسلسلPCR في الدم. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Chest Diseases |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الأمراض الصدرية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pulmonary Arterial Hypertension (PAH) |
| -- | Endothelial cell dysfunction |
| -- | Epstein-Bar Virus (EBV) |
| -- | Chronic active Epstein-Bar infection (CAEBV) |
| -- | Right heart catheter (RHC) |
| -- | dysplasia |
| -- | Idiopathic |
| -- | Connective Tissue Disease (CTD) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reem Ibrahim Mohamed Elkorashy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Gabr Metwally |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoda Mohamed Mahmoud Abdel-hamid |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jumana Hesham Ismail |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Reem Ibrahim Mohamed Elkorashy Prof. Assist. Prof. Dr. |
| -- | Hala Gabr Metwally |
| -- | Hoda Mohamed Mahmoud Abdel-hamid |
| -- | Jumana Hesham Ismail |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Chest Diseases |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 01.11.2025 | 92307 | Cai01.11.06.Ph.D.2025.Ma.E | 01010110092307000 | 01.11.2025 | 01.11.2025 | Thesis |