Evaluation of serum and pleural levels tumor M2-pyruvate kinase in patients with malignant pleural effusion / (Record no. 175352)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06532namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251104130409.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251102s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.2 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.2 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.06.Ph.D.2025.Am.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Amani Moustafa Ali Mazid, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of serum and pleural levels tumor M2-pyruvate kinase in patients with malignant pleural effusion / |
| Statement of responsibility, etc. | by Amani Moustafa Ali Mazid ; Supervisors Prof. Hossam Hosny Masoud, Prof. Hoda Mohamed Abdel-Hamid, Dr.Ahmed Aboelfath Tantawy, Dr. Fatma Abdel-Wahab Abdel-Masoud. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم إنزيم فى الدم مصل Tumor M2-pyruvate kinase والسائل البللوري فى مرضى الإنسكاب البللوري السرطاني |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 87 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 76-87. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Pleural effusion is frequently encountered in hospital admissions. The underlying causes include a wide range of benign, reactive, infective, autoimmune, and neoplastic diseases. tissue biopsy is generally considered more definitive for obtaining a larger volume of tissue. The search for non-invasive identification methods with high sensitivity and specificity has attracted much clinical attention.<br/>Aim of the work: Evaluation of serum and pleural levels of tumor M2-pyruvate kinase in patients with malignant pleural effusion.<br/>Patients and methods: The present case-control study was performed at the Chest Department in collaboration with the Clinical Pathology Department, Faculty of Medicine, Cairo University. The study was performed on 88 patients who were divided into 2 groups; Group 1: consisted of 44 patients with malignant pleural effusion and Group 2: consisted of 44 patients with Non-malignant exudative pleural effusion. All patients were subjected to history taking, full clinical examination, and laboratory investigations including serum albumin, LDH, Protein, and glucose. Serum and pleural fluid samples for tumor M2- pyruvate kinase levels measurement. Plain chest X-ray, CT chest, Pleural fluid aspiration (chemistry, cytology, and TlC differential). Pleural biopsy by medical thoracoscopy or image-guided Pleural biopsy and histopathological examination of biopsy.<br/>Results: Serum M2 pyruvate was significantly higher in patients with malignant effusion with a cutoff value of 1.25 pg/ul, sensitivity 63.6%, and specificity 52.3% (p-value 0.042). Whereas pleural Fluid M2 pyruvate level and M2 pyruvate ratio (P/S) were statistically insignificant between the two groups.<br/>Conclusion: Serum Tumor M2 pyruvate kinase was significantly increased in MPE, which can be used as a non-invasive index to distinguish between malignant and non-malignant pleural effusion. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | يعد الانصباب الجنبي من الحالات التي تُلاحظ بشكل متكرر أثناء الدخول إلى المستشفى. تتضمن الأسباب الكامنة مجموعة واسعة من الأمراض الحميدة، التفاعلية، المعدية، المناعية الذاتية، والأمراض السرطانية. يُعتبر أخذ خزعة الأنسجة عادةً أكثر دقة ويهدف إلى الحصول على حجم أكبر من الأنسجة. وقد جذبت الطرق غير التدخلية ذات الحساسية والنوعية العالية اهتمامًا كبيرًا في المجال الطبي. تركز العديد من الدراسات التي تبحث في الدور التشخيصي لتحليل السوائل الجنبية البيوكيميائية على التمييز بين الانصباب الجنبي الخبيث وغير الخبيث.<br/><br/><br/>تم إجراء الدراسة الحالية على 88 مريضًا تم تحويلهم إلى قسم الصدر بمستشفى قصر العيني لتقييم<br/>مستويات إنزيم -M2بيروفات كيناز في الدم والسائل الجنبي لدى المرضى المصابين بالانصباب الجنبي الخبيث وغير الخبيث. تم تقسيم المرضى إلى مجموعتين: المجموعة (1) تضمنت 44 مريضًا بالانصباب الجنبي الخبيث، والمجموعة (2) تضمنت 44 مريضًا بالانصباب الجنبي النضحي غير الخبيث.<br/>جميع المرضى خضعوا لما يلي:<br/>أخذ التاريخ الطبي مع التركيز على العمر، الجنس، تاريخ التدخين، تاريخ الإصابة بالأورام، مكان الإقامة، وأعراض المريض.<br/>الفحص السريري العام والموضعي.<br/>التحاليل المعملية: CBC)، PC، (INR، )الألبومين في الدم، LDH، البروتين والجلوكوز.( أشعة سينية على الصدر، أشعة مقطعية على الصدر.<br/>تحليل السائل الجنبي الكيميائي )الألبومين، LDH، البروتين والجلوكوز( وتعداد الخلايا التفاضلي. صبغة جرام، وعمل مزرعة للسائل الجنبي.<br/>أخذ خزعة جنبية بواسطة منظارصدري طبي أو تحت توجيه الأشعة . فحص أنسجة الخزعة.<br/>قياس مستويات إنزيم -M2بيروفات كيناز في الدم والسائل الجنبي. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Chest Diseases |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الأمراض الصدرية |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | malignant pleural effusion |
| -- | M2 pyruvate kinase |
| -- | pleural fluid biomarkers |
| -- | mesothelioma |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hossam Hosny Masoud |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoda Mohamed Abdel-Hamid |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Aboelfath Tantawy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fatma Abdel-Wahab Abdel-Masoud |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Hossam Hosny Masoud |
| -- | Hoda Mohamed Abdel-Hamid |
| -- | Ahmed Aboelfath Tantawy |
| -- | Fatma Abdel-Wahab Abdel-Masoud |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Chest Diseases |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 02.11.2025 | 92314 | Cai01.11.06.Ph.D.2025.Am.E | 01010110092314000 | 02.11.2025 | 02.11.2025 | Thesis |