Potential mechanisms of ticagrelor in modulating neurodegeneration in rotenone-induced parkinsonism in rats / (Record no. 175528)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05603namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251105105255.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251104s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.1 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.1 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.09.Ph.D.2025.Mu.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Muhammad Muneeb Muhammad Abdulazeem, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Potential mechanisms of ticagrelor in modulating neurodegeneration in rotenone-induced parkinsonism in rats / |
| Statement of responsibility, etc. | by Muhammad Muneeb Muhammad Abdulazeem ; Supervision Dr. Dalaal Moustafa Abdallah, Dr. Hanan Salah El-Din El-Abhar, Dr. Walaa Wadie Ibrahim, Dr. Yasmin Saad Abulfadl. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | آليات تيكاجريلورالممكنه في تخفيفالإنتكاس العصبي المُحدث في الجرذان المصابة بالشلل الرعاش المُحدث بالروتينون |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 107 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 78-107. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Cardiovascular diseases, such as myocardial infarction, ischemic stroke, and coronary heart ailments have been closely associated with Parkinson’s disease (PD). Despite this established link, the potential neuroprotective impact of the potent antiplatelet agent ticagrelor (Tica) remains unexplored against PD. Thus, we hypothesized that Tica could be repurposed as a therapeutic agent against PD. <br/> The rotenone experimental model was adopted in Wistar male rats by administering rotenone subcutaneously on alternate days during a 21-day experimental period and treating a subset of rats with Tica orally for the last 11 consecutive days.<br/> The administration of Tica improved motor function (open field test, hanging wire test) and restored striatal histological features. Additionally, Tica opposed the rotenone effect and markedly obliterated the striatal alpha-synuclein content but enhanced the protein expression of tyrosine hydroxylase and dopamine content. On the molecular level, Tica inhibited striatal endoplasmic reticulum stress (ERS) as evidenced by the downregulation of the ER-resident transmembrane sensor inositol-requiring enzyme 1 alpha and its downstream molecular targets, TNF receptor-associated factor 2 and c-Jun N-terminal kinase, along with a reduction in caspase-3 activity. On the other hand, Tica augmented the autophagy machinery by upregulating the autophagosome markers Beclin-1 and light chain 3-II, while inhibiting the content of cathepsin-D.<br/> Therefore, the current study is the first to accentuate the neuroprotective potential of Tica in a rat model of PD via modulating the crosstalk between ERS, apoptosis, and autophagy to represent a potential novel therapeutic candidate for managing PD, particularly in patients with or prone to cardiovascular diseases. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | يعد مرض الشلل الرعاش ثاني أكثر الاضطرابات العصبية التنكسية والذي يتميز بالتنكس المستمر للخلايا العصبية الدوبامينية في المادة السوداء مما ينتج عنهنقصللدوبامين و يؤدي إلى صعوبات حركية. لذلك يعد نموذج الروتينون نموذجا جيدًا للدراسات التجريبيةحيث أن السمات المرضية لمرض الشلل الرعاش الناجم عن الروتينون تتشابه إلى حد كبير في العديد من الآليات الخاصة بمرض الشلل الرعاش والتي تشمل إعاقة إشارات الإلتهام الذاتي ونشاطإجهادالشبكة الإندوبلازمية والموت الخلوي، بالإضافة إلى انخفاض مستويات الدوبامين وإنزيم التيروزين هيدروكسيليز، وزيادة مستويات الألفا سينوكيولين.<br/>الجدير بالذكر أن دواء تيكاجريلوريعمل كمضاد لمستقبلات بي ٢ واي ١٢ وله فوائد علاجية عديده حيث يعمل كمضاد للتجلط نتيجة تثبيط تجمع الصفائح الدموية.وبالإضافة الى ذلك أثبت هذا الدواء خواصه كمضاد للإلتهابات وللإلتهام الذاتي وللأكسدة من خلال مسارات إشارات مختلفة. تقع مستقبلات بي ٢ واي ١٢ في العديد من المواقع المركزية بما في ذلك الجسم الثفني والحُصين والمادة السوداءوالمهاد. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drugs |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | العقاقير |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ticagrelor |
| -- | Rotenone |
| -- | Parkinson's disease |
| -- | Endoplasmic-reticulum stress |
| -- | Apoptosis |
| -- | Autophagy |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalaal Moustafa Abdallah |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Salah El-Din El-Abhar |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walaa Wadie Ibrahim |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yasmin Saad Abulfadl |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Dalaal Moustafa Abdallah |
| -- | Hanan Salah El-Din El-Abhar |
| -- | Walaa Wadie Ibrahim |
| -- | Yasmin Saad Abulfadl |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmacology & Toxicology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 04.11.2025 | 92370 | Cai01.08.09.Ph.D.2025.Mu.P | 01010110092370000 | 04.11.2025 | 04.11.2025 | Thesis |