Expression pattern and clinical significance of EXT1 in breast cancer / (Record no. 175637)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 07243namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251109100151.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251109s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.99449 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.99449 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.21.M.Sc.2025.Am.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Amira Hossny Awad Hassan Elbanna, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Expression pattern and clinical significance of EXT1 in breast cancer / |
| Statement of responsibility, etc. | by Amira Hossny Awad Hassan Elbanna ; Supervisors Prof. Dr. Sherif Abdelaziz Ibrahim, Prof. Dr. Ahmed Hassan Abd El-Raouf, Prof. Dr. Mahmoud Mohamed Kamel. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | اﻟﻨﻤﻂ اﻟﺘﻌﺒﯿﺮي واﻷھﻤﯿﺔ اﻟﺴﺮﯾﺮﯾﺔ ل "أي اﻛﺲ ﺗﻲ ١ " ﻓﻲ ﺳﺮطﺎن اﻟﺜﺪي |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 99 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 75-96. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Exostosin 1 (EXT1) encodes a type II transmembrane glycosyltransferase residing in the endoplasmic reticulum and plays an essential role in the elongation of heparan sulfate chain biosynthesis. Additionally, EXT1 may act as an oncogene, promoting cell proliferation and metastasis of cancer cells. Aim of study: to assess the expression pattern, prognostic value, and immunological implications of EXT1 in breast cancer. Materials and Methods: Immunohistochemical staining of EXT1 was evaluated in 85 breast cancer patients. Patients were categorized into molecular subtypes, such as luminal A, luminal B, human epidermal growth factor receptor 2 (HER2), and triple-negative breast cancer (TNBC). Correlations of EXT1 immunostaining with clinicopathological parameters, tumor immune infiltration, and immune cell surface markers assessed by TIMER were analyzed. Furthermore, survival analysis was conducted to reveal EXT1’s prognostic value. Results: EXT1 expression was significantly associated with estrogen receptor (ER) status, molecular sub-types, and recurrence status. Moreover, EXT1 expression was positively associated with poor overall survival (OS) and relapse-free survival (RFS). Immune<br/>infiltration analysis indicated that EXT1 expression was positively correlated with CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells (DCs), although it showed a negative correlation with tumor purity. Conclusion: Overall, this study suggests that the elevated EXT1 expression, particularly in TNBC, is positively correlated with poor prognosis and with immune-infiltrated cells in breast cancer. Therefore, it may emerge as an independent prognostic biomarker, immunological marker, and a potential future therapeutic target for the most aggressive TNBC subtype. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | اﻟﺨﻠﻔﯿﺔ: ﯾُﺸﻔّﺮ ﺟﯿﻦ اﻛﺴﻮﺳﺘﻮﺳﻦ 1) EXT1) ﻹﻧﺰﯾﻢ ﻏﻠﯿﻜﻮزﯾﻠﺘﺮاﻧﺴﻔﯿﺮاز ﻣﻦ اﻟﻨﻮع اﻟﺜﺎﻧﻲ اﻟﺬي ﯾﻘﺒﻊ ﻓﻲ اﻟﺸﺒﻜﺔ اﻹﻧﺪوﺑﻼزﻣﯿﺔ، وﯾﻠﻌﺐ دورً ا أﺳﺎﺳﯿًﺎ ﻓﻲ إطﺎﻟﺔ ﺳﻠﺴﻠﺔ ﺗﺨﻠﯿﻖ اﻟﮭﯿﺒﺎران ﺳﻠﻔﺎت. ﺑﺎﻹﺿﺎﻓﺔ إﻟﻰ<br/>ذﻟﻚ، ﻗﺪ ﯾﻌﻤﻞEXT1 ﻛﺠﯿﻦ ﻣﺴﺮطﻦ، ﻣﻤﺎ ﯾﻌﺰز ﺗﻜﺎﺛﺮ اﻟﺨﻼﯾﺎ واﻧﺘﻘﺎل اﻟﺨﻼﯾﺎ اﻟﺴﺮطﺎﻧﯿﺔ. ھﺪف اﻟﺪراﺳﺔ :ﻛﺎن اﻟﮭﺪف ﻣﻦ اﻟﺪراﺳﺔ ﺗﻘﯿﯿﻢ ﻧﻤﻂ اﻟﺘﻌﺒﯿﺮ واﻟﻘﯿﻤﺔ اﻟﺘﻨﺒﺆﯾﺔ واﻵﺛﺎر اﻟﻤﻨﺎﻋﯿﺔ ﻟـEXT1 ﻓﻲ<br/>ﺳﺮطﺎن اﻟﺜﺪي. اﻟﻤﻮاد واﻟﻄُﺮق :ﺗﻢ ﺗﻘﯿﯿﻢ ﺻﺒﻐﺔ اﻟﻤﻨﺎﻋﯿﺔ ﻟـEXT1 ﻓﻲ 85 ﻣﺮﯾﻀﺔ ﺑﺴﺮطﺎن اﻟﺜﺪي. ﺗﻢ ﺗﺼﻨﯿﻒ اﻟﻤﺮﺿﻰ إﻟﻰ اﻷﻧﻮاع اﻟﻔﺮﻋﯿﺔ اﻟﺠﺰﯾﺌﯿﺔ ﻣﺜﻞ ﻟﻮﻣﻨﺎلA ، ﻟﻮﻣﻨﺎلB ، ﻣﺴﺘﻘﺒﻼت ﻋﺎﻣﻞ اﻟﻨﻤﻮ اﻟﺒﺸﺮي HER2)2) ، وﺳﺮطﺎن اﻟﺜﺪي اﻟﺜﻼﺛﻲ اﻟﺴﻠﺒﻲ TNBC)(. ﺗﻢ ﺗﺤﻠﯿﻞ اﻟﻌﻼﻗﺎت ﺑﯿﻦ ﺻﺒﻐﺔ<br/>EXT1اﻟﻤﻨﺎﻋﯿﺔ واﻟﻤﻌﺎﯾﯿﺮ اﻹﻛﻠﯿﻨﯿﻜﯿﺔ اﻟﻤﺮﺿﯿﺔ، ﺗﺴﻠﻞ اﻟﻮرم اﻟﻤﻨﺎﻋﻲ، وﻋﻼﻣﺎت ﺳﻄﺢ اﻟﺨﻼﯾﺎ اﻟﻤﻨﺎﻋﯿﺔ اﻟﺘﻲ ﺗﻢ ﺗﻘﯿﯿﻤﮭﺎ ﺑﺎﺳﺘﺨﺪام ﻗﺎﻋﺪة ﺑﯿﺎﻧﺎت TIMER. ﻋﻼوة ﻋﻠﻰ ذﻟﻚ، ﺗﻢ إﺟﺮاء ﺗﺤﻠﯿﻞ ﻟﻠﺒﻘﺎء ﻟﻠﻜﺸﻒ ﻋﻦ<br/>اﻟﻘﯿﻤﺔ اﻟﺘﻨﺒﺆﯾﺔ ﻟـEXT1 . اﻟﻨﺘﺎﺋﺞ :ﻛﺎن ﺗﻌﺒﯿﺮ EXT1 ﻣﺮﺗﺒﻄًﺎ ﺑﺸﻜﻞ ﻛﺒﯿﺮ ﺑﺤﺎﻟﺔ ﻣﺴﺘﻘﺒﻼت اﻹﺳﺘﺮوﺟﯿﻦ ER)(، اﻷﻧﻮاع اﻟﻔﺮﻋﯿﺔ اﻟﺠﺰﯾﺌﯿﺔ، وﺣﺎﻟﺔ اﻟﺘﻜﺮار. ﺑﺎﻹﺿﺎﻓﺔ إﻟﻰ ذﻟﻚ، ﻛﺎن ﺗﻌﺒﯿﺮEXT1 ﻣﺮﺗﺒﻄًﺎ ﺑﺸﻜﻞ إﯾﺠﺎﺑﻲ ﺑﺴﻮء اﻟﺒﻘﺎء اﻟﻌﺎم OS)( واﻟﺒﻘﺎء اﻟﺨﺎﻟﻲ ﻣﻦ اﻻﻧﺘﻜﺎس RFS)(. أظﮭﺮ ﺗﺤﻠﯿﻞ ﺗﺴﻠﻞ<br/>اﻟﻤﻨﺎﻋﺔ أن ﺗﻌﺒﯿﺮ EXT1 ﻛﺎن ﻣﺮﺗﺒﻄًﺎ إﯾﺠﺎﺑﯿًﺎ ﻣﻊ ﺧﻼﯾﺎT اﻟﺴﺎﻣﺔCD8)+( ، ﺧﻼﯾﺎT اﻟﻤﺴﺎﻋﺪة( CD4)+ ، اﻟﺒﻼﻋﻢ، اﻟﺨﻼﯾﺎ اﻟﻤﺘﻌﺎدﻟﺔ، واﻟﺨﻼﯾﺎ اﻟﻤﺘﻐﺼﻨﺔ(DCs) ، ﻋﻠﻰ اﻟﺮﻏﻢ ﻣﻦ أﻧﮫ أظﮭﺮ ارﺗﺒﺎطًﺎ ﺳﻠﺒﯿًﺎ ﻣﻊ ﻧﻘﺎء اﻟﻮرم. اﻟﺨﻼﺻﺔ: ﺑﺸﻜﻞ ﻋﺎم، ﺗﺸﯿﺮ ھﺬه اﻟﺪراﺳﺔ إﻟﻰ أن ارﺗﻔﺎع ﺗﻌﺒﯿﺮEXT1 ، ﺧﺎﺻﺔ<br/>ﻓﻲ ﻧﻮعTNBC ، ﻣﺮﺗﺒﻂ ﺑﺸﻜﻞ إﯾﺠﺎﺑﻲ ﺑﺴﻮء اﻟﺘﻨﺒﺆ وﺑﺘﺴﻠﻞ اﻟﺨﻼﯾﺎ اﻟﻤﻨﺎﻋﯿﺔ ﻓﻲ ﺳﺮطﺎن اﻟﺜﺪي. وﺑﺎﻟﺘﺎﻟﻲ، ﻗﺪ ﯾﻈﮭﺮEXT1 ﻛﻌﻼﻣﺔ ﺗﻨﺒﺆﯾﺔ ﻣﺴﺘﻘﻠﺔ، وﻋﻼﻣﺔ ﻣﻨﺎﻋﯿﺔ، وھﺪﻓًﺎ ﻋﻼﺟﯿًﺎ ﻣﺴﺘﻘﺒﻠﯿًﺎ ﻷﻧﻮاع<br/>ﺳﺮطﺎن اﻟﺜﺪي اﻷﻛﺜﺮ ﻋﺪواﻧﯿﺔ. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Breast cancer |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | سرطان الثدى |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Exostosin 1 (EXT1) |
| -- | Heparan Sulfate |
| -- | breast cancer |
| -- | prognosis |
| -- | immune infiltration |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherif Abdelaziz Ibrahim |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Hassan Abd El-Raouf |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Mohamed Kamel |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Sherif Abdelaziz Ibrahim |
| -- | Ahmed Hassan Abd El-Raouf |
| -- | Mahmoud Mohamed Kamel |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Zoology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 09.11.2025 | 92426 | Cai01.12.21.M.Sc.2025.Am.E | 01010110092426000 | 09.11.2025 | 09.11.2025 | Thesis |