The possible antineoplastic activity of Allolobophora caliginosa coelomic fluid against Ehrlich ascites carcinoma in Swiss albino mice / (Record no. 175663)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05921namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251109132831.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251109s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 573 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 573 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.21.M.Sc.2025.Mo.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Moshera Gamal Sayed, |
| Preparation | preparation. |
| 245 14 - TITLE STATEMENT | |
| Title | The possible antineoplastic activity of Allolobophora caliginosa coelomic fluid against Ehrlich ascites carcinoma in Swiss albino mice / |
| Statement of responsibility, etc. | by Moshera Gamal Sayed ; Supervisors Prof. Dr. Amel Mahmoud Soliman, Prof. Dr. Sohair Ramadan Fahmy, Dr. Shimaa Ahmed Sadek. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | النشاط المضاد للأورام المحتمل للسائل الجوفي للألولوبوفرا كاليجينوزا ضد سرطان إيرلش الإستسقائي في الفئران السويسرية البيضاء |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 257 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 188-257. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Allolobophora caliginosa has been widely utilized in the pharmaceutical industry because it has many therapeutic properties that attributed to its coelomic fluid. Hence, the current study was intended to identify the bioactive constituents and the biological activities of Allolobophora caliginosa coelomic fluid (ACCF) and its the possible antitumor effect against Ehrlich ascites carcinoma (EAC) in female Swiss albino mice. The effectiveness of ACCF was compared with fluorouracil (Flu) as a standard chemotherapy drug. Various active phenolic and flavonoid constituents and a considerable amount of essential and non-essential amino acids were found in ACCF. The current study clarified that ACCF exhibited dose-dependent radical scavenging and potent anti-inflammatory activities. Furthermore, the proliferation of HepG-2 could be inhibited by ACCF with the IC50 value of 145.99 μg/ml. The present findings revealed that ACCF showed amazing peripherally and centrally analgesic and antipyretic potencies. ACCF has various secondary metabolites that were likely to act synergistically to produce the observed biological activities. Besides, oral administration of ACCF for 9 days caused a significant amelioration in all the hematological parameters relative to the untreated EAC group. Markedly, ACCF administration significantly enhanced hepatic function by the reduction in liver enzyme activities such as ALT, AST, GGT, and lactate as well as the increase in total protein and albumin content. As well as, ACCF treatment improved renal function as indicated by the reduction in serum creatinine, urea and uric acid. Concerning lipid metabolism, ACCF treatment caused a marked enhancement in lipid metabolism, as indicated by a significant decrease in serum total cholesterol and triglycerides levels. Moreover, ACCF treatment could hinder the hepatic and renal oxidative stress induced by EAC via a noticeable increase in both hepatic and renal GSH content and antioxidant enzyme activities (SOD, CAT, and GST) besides reduction in MDA and NO formation. Administration of ACCF repairs, to some extent, the abnormal architecture of hepatic tissue induced by EAC. Finally, ACCF could be used as a prospective anti-tumor and hepato-renal protective alternative remedy. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | تهدف الدراسة الحالية إلي تقييم الفعالية المضادة للأورام للسائل الجوفي للألولوبوفرا كاليجينوزا ضد سرطان إيرلش الإستسقائي من خلال التعرف علي المركبات البيولوجية النشطه له. و أوضحت الدراسة الحالية العديد من الأنشطة البيوليوجية المختلفة للسائل الجوفي للألولوبوفرا كاليجينوزا مثل النشاط المضادة للأكسدة, نشاطًا قويًا مضادًا للالتهابات, نشاطاً فعالاً ضد سرطان الكبد الوبائي-2. كما لدية القدرة علي التخفيف من حدة الألم و إنخفاض درجة حرارة الجسم. كما أوضحت الدراسة الحالية أن سرطان إيرلش الإستسقائي تسبب في أضرار غير المرغوب فيها لمعظم القياسات البيوكيميائية. كما وجد تغير باثولوجي في كبد الفئران المصابة بسرطان إيرلش الإستسقائي. بينما أدت المعالجة بالسائل الجوفي للألولوبوفرا كاليجينوزلمدة 9 أيام إلي تثبيط نشاط الخلايا السرطانيه . كما أدت إلي تحسن لمعظم القياسات البيوكيميائية و التركيب النسيجي للكبد إلي مستوي يقترب من التركيب الطبيعي. و هذا وجد علي التوافق مع نتائج الفلورويورسيل كدواء للسرطان. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animal physiology |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | فيسولوجيا الحيوانات |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Allolobophora caliginosa coelomic fluid |
| -- | Ehrlich ascites carcinoma |
| -- | Antioxidant |
| -- | Hepatorenal disorders |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amel Mahmoud Soliman |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sohair Ramadan Fahmy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shimaa Ahmed Sadek |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Amel Mahmoud Soliman |
| -- | Sohair Ramadan Fahmy |
| -- | Shimaa Ahmed Sadek |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Zoology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 09.11.2025 | 92429 | Cai01.12.21.M.Sc.2025.Mo.P | 01010110092429000 | 09.11.2025 | 09.11.2025 | Thesis |