Evaluation of chemopreventive efficacy of pomegranate polysaccharide loaded- nanoemulsion on colorectal cancer induced by dimethyl hydrazine in rats / (Record no. 175725)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06199namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251116122746.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251110s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.994347 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.994347 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.21.M.Sc.2024.Sa.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Samah Shaaban Hosney Mohammed , |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of chemopreventive efficacy of pomegranate polysaccharide loaded- nanoemulsion on colorectal cancer induced by dimethyl hydrazine in rats / |
| Statement of responsibility, etc. | by Samah Shaaban Hosney Mohammed ; Supervisors Prof. Dr. Amel Mahmoud Solima, Prof.Dr.Sohair Ramadan Fahmy, Dr.Shimaa Ahmed Sadek. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | : تقيم فعالية الوقاية الكيميائية للمستحلب النانومتري المحمل بالسكريات العديدة للرمان علي سرطان القولون والمستقيم المستحث بثنائي ميثيل هيدرازين في الجرذان |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 229 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 167-229. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: The prevalence and mortality rates of colorectal cancer (CRC) are <br/>increasing at an alarming rate in recent decades. Chemoprevention strategies <br/>utilizing natural supplements provide chances to delay the CRC development <br/>and reverse the progression of CRC. Therefore, the present study was intended <br/>to develop nanoemulsion, a potential drug delivery system, for pomegranate <br/>polysaccharide (PGPs) for enhancing it’s oral bioavailability and evaluate it’s <br/>efficacy in treating CRC in rats. The current study demonstrated that PGPs <br/>successfully encapsulated within nanoemulsion with a relatively high <br/>encapsulation efficiency (92.82%) providing an effective encapsulation for <br/>delivery system in the body. The in vitro experiments showed that pomegranate <br/>polysaccharide loaded-nanoemulsion had good antioxidant and antitumor <br/>abilities more than PGPs. In vivo study demonstrated that the PGP-NE decrease <br/>body weight gain resulted from 1,2 Dimethylhydrazine (DMH) administration <br/>and help in decreasing tumor size and multiplicity, incidence and while <br/>increasing relative liver weight, colon weight length ratio and mortality. The <br/>PGP-NE act as anti-inflammatory and help to significantly reduce the increase <br/>in IL-6 and MMP9 levels which resulted after administration of DMH. The <br/>PGPs-NE significantly attenuate dyslipidemia, as indicated by significant <br/>decrease in level of total cholesterol and triglyceride. Furthermore, the PGPs-NE <br/>improve the liver function markers (AST, ALP, ALT, LDH and GGT). <br/><br/><br/>Additionally, PGPs NE attenuate oxidative stress induced by DMH, as <br/>confirmed by a significant decrease in MDA level and marked increase <br/>antioxidant markers (GSH, SOD, CAT). It was concluded that PGPs NE can be <br/>used as a promising antineoplastic remedy. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | الهدف:تهدف هذه الرساله الي تطوير المستحلب النانومتري من متعدد السكريات المستخلص من الرمان (PGP_NE)وتوصيفه من حيث الخصائص الفيزيائيه والكيميائيه، بالاضافه الي دراسه انشطته البيولوجيه،مثل الخصائص المضاده للاكسده، والمضاده للالتهابات، والمضاد للتكاثر الخلوي، مع تقييم سميته علي الفئران .<br/>المواد والطرق:تم تحفيز سرطان القولون في الفئران باستخدام مادة 1,2-dimethylhydrazine (DMH)، وهي مادة مسرطنة معروفة تُستخدم في النماذج الحيوانية لمحاكاة تطور سرطان القولون البشروأيضا تقييم العلامات الالتهابية والمضادة للأكسدة(مثلوMDA وGSH).<br/>النتائج:أظهرت مجموعات PGPs-NE (خاصة بجرعة 50 مجم/كجم) تحسنًا ملحوظًا في جميع المعايير مقارنة بمجموعة DMH فقط كما انخفض عدد ACF بشكل واضح وايضاارتفع مستوى المؤشرات المضادة للأكسدة وانخفضت المؤشرات الالتهاب و تم تحفيز موت الخلايا المبرمج (apoptosis) في الخلايا السرطانية من خلال تعديل تعبير الجينات المرتبطة به<br/><br/>الاستنتاج:أظهرت النتائج أن PGPs-NE أظهر نشاطًا مضادًا للسرطان أعلى بكثير من PGPs الخام وُجد أن المستحلب النانوي قد قلل من حيوية خلايا HepG2 بطريقة تعتمد على الجرعة. وكانت قيمة IC₅₀للمستحلب النانوي أقل بكثير من قيمة IC₅₀ للمستخلص الخام، مما يشير إلى فعالية أعليوأيضا تم تفسير هذا التأثير المحسّنجزئيًا بسبب الخصائص التركيبية للمستحلب النانوي، مثل الحجم النانوي وتوزيع القطر المناسب، الذي يسهل الامتصاص الخلوي ويحسن التوافر الحيوي |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Colorectal Neoplasms |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | أورام القولون والمستقيم |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Dimethyl hydrazine |
| -- | colorectal cancer |
| -- | Pomegranate |
| -- | polysaccharides |
| -- | anti-inflammatory |
| -- | Nanoemulsion |
| -- | oxidative stress |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amel Mahmoud Solima |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sohair Ramadan Fahmy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shimaa Ahmed Sadek |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Amel Mahmoud Solima |
| -- | Sohair Ramadan Fahmy |
| -- | Shimaa Ahmed Sadek |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Zoology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 16.11.2025 | 92438 | Cai01.12.21.M.Sc.2024.Sa.E | 01010110092438000 | 16.11.2025 | 16.11.2025 | Thesis |