Effect of ramadan fasting by type 2 diabetes patients on liver-type fatty acid-binding protein l-fabp as a marker of kidney injury : (Record no. 175953)
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| 000 -LEADER | |
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| fixed length control field | 07957namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251209120529.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251117s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.18.M.Sc.2024.Sa.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Sarah Ahmed Mohamed Kamel, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of ramadan fasting by type 2 diabetes patients on liver-type fatty acid-binding protein l-fabp as a marker of kidney injury : |
| Remainder of title | A pilot Study / |
| Statement of responsibility, etc. | by Sarah Ahmed Mohamed Kamel ; Supervision Prof.Dr. Abir Zakaria Mohamed Said, Dr. Mohammed Gomaa Hammad, Dr.Eman Al Hussain Abdul Gawad. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تاثير صيام شهر رمضان الكريم على مرضى السكري من النوع الثاني من خلال متابعة البروتين الكبدي المرتبط بالأحماض الدهنية كدليل على تأثر الكلى : |
| Remainder of title | دراسة تجريبية |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 133 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 106-133. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background; Kidney disease is a serious complication with negative impacts on health, quality of life and even life expectancy. Early detection and intervention are essential in the prevention and treatment of diabetic nephropathy (DN). Liver-type fatty acid-binding protein L-FABP is an intracellular fatty acid carrier protein which expresses mainly in the liver and kidney. L-FABP was associated with renal tubulointerstitial damage due to excessive reabsorption of free fatty acid. <br/>Aim and objectives; the main aim of this study was to detect the effect of Ramadan fasting on kidneys of type 2 diabetic patients through measuring urinary L-FABP level before, during and after the holy month of Ramadan. <br/>Subjects and methods; This cross-sectional analytic study was carried on 80 type 2 diabetic patients who insist to fast during the holy month of Ramadan. the study conducted in 2022 gregorian and 1443 hijri. While the fasting hours per day were about 15. The samples during Ramadan have been collected after 2 weeks of contineous fasting. The climate during Ramadan 1443 was warm and tolerable. <br/>Result; regardingL-FABPThe mean urinary L-FABP levels were 336.6, 299.7 and 318.8 unit when measured before, during and after fasting respectively.there was no statistically significant difference between the results of urinary L-FABP levels (P=0.243),Although there is a numerical decline in L-FABP levels during Ramadan which increased again after Ramadan but still below the levels before Ramadan.<br/>Regarding investigations for glycaemic control, the mean HbA1c before, during and after fasting were 8.9%, 8.4% and 8.3% respectively. Repeated-measurement ANOVA was run to check statistically significant change in HbA1c values, and we found it to be statistically significant. Comparing blood glucose levels by pairwise analysis using related samples Wilcoxon signed rank test confirmed significant change in levels before and during fasting. <br/>Urinary investigations analysis revealed a statistically significant difference between the results of the urinary A/C ratio obtained before, during and after fasting (p-value= 0.001) and the significance was also present comparing the results during and before fasting. <br/>Conclusion; In the current study, we revealed that there was no statistically significant difference between the results of urinary L-FABP levels when measured before, during and after Ramadan fasting respectively,Although there is a numerical decline in L-FABP levels during Ramadan which increased again after Ramadan but still below the L-FABP levels before Ramadan.Also L-FABP does not correlate to HbA1c, eGFR,creatinine,a/c ratio and BMI. Also, we found that fasting during the month of Ramadan does not affect kidney functions.Ramadan fasting has positive effects on T2DM patients as it reduces their blood glucose and HbA1C. . <br/>Further studies are needed with larger scales for confirming our results. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | تم التعرف على داء السكري(DM) منذ فترة طويلة باعتباره اضطراب التمثيل الغذائي الأكثر شيوعًا في جميع أنحاء العالم. داء السكري هو مجموعة من الأمراض التي تتميز في المقام الأول بارتفاع السكر في الدم المزمن بسبب عدم وجود عمل كاف للأنسولين. ينقسم مرض السكري تقريبًا إلى النوع الأول والنوع الثاني . <br/>رمضان هو الشهر التاسع من التقويم الإسلامي ويمارس المسلمون الصيام الإلزامي خلال هذا الشهر والذي قد يتراوح من 12 إلى 16 ساعة وأحيانًا أكثر في بعض البلدان حسب موقعها الجغرافي وموسمها . <br/>صيام شهر رمضان، أحد أركان الإسلام الخمسة، هو واجب إلزامي على جميع المسلمين البالغين الأصحاء. يجب على المسلمين خلال شهر رمضان الامتناع عن الأكل والشرب وتناول الأدوية عن طريق الفم، والتدخين من طلوع الفجر حتى غروب الشمس؛ لا توجد قيود على تناول الطعام أو السوائل بين غروب الشمس والفجر . <br/>يعد اعتلال الكلية السكري(DN) واحدًاً من أخطر مضاعفات الأوعية الدموية الدقيقة لمرض السكري من النوع 2، وهو أحد الأسباب الرئيسية للفشل الكلوي في المرحلة النهائية والوفاة لدى مرضى السكري. وهو أحد الأسباب الأكثر شيوعًا لمرض الكلى المزمن في جميع أنحاء العالم. <br/> البروتينالكبدي المرتبط بالأحماض الدهنية L-FABP هو بروتين حامل للأحماض الدهنية داخل الخلايا والذي يتم التعبير عنه بشكل رئيسي في الكبد والكلى. ارتبط L-FABP بالتلف الأنبوبي الخلالي الكلوي بسبب إعادة الامتصاص المفرط للأحماض الدهنية الحرة.<br/>تم الإبلاغ عن أن إفراز البول لـ(L-FABP) يوفر علامة حيوية محتملة للكشف المبكر عن اختلال وظائف الكلى سواء كان حاداً أو مزمنًا وبالتالي تحديد المرضى الذين من المحتمل أن يتعرضوا لتدهور وظائف الكلى في المستقبل. <br/> في دراسة مستقبلية حديثة، وجد أن L-FABP البولية أكثر حساسية من البيلة البروتينية في التنبؤ بتطور مرض الكلى المزمن . |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Internal Medicine |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الطب الباطي |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetes mellitus (DM) |
| -- | diabetic nephropathy (DN) |
| -- | chronic kidney disease (CKD) |
| -- | Liver-type fatty acid |
| -- | binding protein L |
| -- | FABP |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abir Zakaria Mohamed Said |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Gomaa Hammad |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Al Hussain Abdul Gawad |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Abir Zakaria Mohamed Said |
| -- | Mohammed Gomaa Hammad |
| -- | Eman Al Hussain Abdul Gawad |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Internal medicine |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 17.11.2025 | 92506 | Cai01.11.18.M.Sc.2024.Sa.E | 01010110092506000 | 17.11.2025 | 17.11.2025 | Thesis |