Biochemical and genetic study of vitamin D receptor and its role in female patients with multiple sclerosis / (Record no. 176318)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05612namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251221105442.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251129s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 574.192 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 574.192 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.02.Ph.D.2025.Am.B |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Amira Ibrahim Ahmed Zayed, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Biochemical and genetic study of vitamin D receptor and its role in female patients with multiple sclerosis / |
| Statement of responsibility, etc. | by Amira Ibrahim Ahmed Zayed ; Supervisors Prof. Dr. Mohamed Ali El-Desouky, Prof. Dr. Noha Taha Abo Krysha. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة بيوكميائية وجينية لمستقبل فيتامين د ودوره فى الاناث المصابات بمرض التصلب المتعدد بالجهاز العصبي |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 110 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 91-107. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Multiple sclerosis (MS) is a progressive demyelinating disease that has been linked to different polymorphisms in the vitamin D receptor (VDR) gene. This study aimed to investigate the correlation between vitamin D levels and VDR gene polymorphisms Bsm1 and Fok1 with the risk of MS in Egyptian females.<br/>Method: A cross-sectional, case-control analytical study enrolled 50 female patients with definite MS Fifty and matched healthy volunteers, as the control group. Pregnant females, patients with other neurological or autoimmune disease were excluded. Serum vitamin D was measured by ELISA. Genomic DNA was extracted from peripheral blood and VDRG polymorphisms that were studied in the study population. <br/>Result: Vitamin D levels showed a statistically significant difference between the cases. The b allele was the most frequent allele for the Bsm1 (74% among the cases and 76% among the controls). The b/b genotype was also the most observed in both groups counting as 58% among the cases and 60% among the controls. For the Fok1, The F allele was the most frequent (64% among the cases and 69% among the controls). The F/F heterozygote genotype was the most observed in both cases and controls, counting as 44% and 50% respectively. Association between the Bsm1 and Fok1 SNPs and MS were examined under dominant, recessive, and co-dominant genetic models. There were non-statistically significant associations between any of the SNPs and MS under the three tested models.<br/>Conclusion: This study concluded that the Bsm1 and Fok1 polymorphisms of the VDR gene are not associated with MS risk in female Egyptian patients. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | المقدمة: مرض التصلب العصبي المتعدد هو نتيجة لخلل بجهاز المناعة مما يؤدي إلي إلتهاب متناثر بالجهاز العصبي المركزي و يتميز بظهور جروح على شكل التهاب ناتج عن إزالة الميالاين من محاور الاعصاب تم ربطه بأشكال مختلفة في جين مستقبل فيتامين د (VDR). <br/>الهدف من الدراسة: هدفت هذه الدراسة إلى معرفة الارتباط بين مستوي فيتامين د و تعدد الأشكال النيوكليوتيدات المفردة BSMI وFokI في مستقبل فيتامين د ( (VDRو احتمالية الاصابة بمرض التصلب المتعدد في الاناث<br/>النتائج:. أظهرت مستويات فيتامين د تغير بين الحالات و. كان الأليل b هو الأليل الأكثر شيوعًا لـBsm-I 74% بين الحالات و76% بين الضوابط). كان النمط الجيني b/b أيضًا هو الأكثر ملاحظة في كلا المجموعتين حيث بلغ 58% بين الحالات و60% بين الضوابط. بالنسبة لـ Fok-I، كان الأليل F هو الأكثر شيوعًا (64% بين الحالات و69% بين اللضوابط). كان النمط الجيني متغاير الزيجوت F/F هو الأكثر ملاحظة في كل من الحالات والضوابط، حيث بلغ 44% و50% على التوالي. تم فحص الارتباط بين Bsm-I وFok-I SNPs وMS في ظل النماذج الوراثية السائدة والمتنحية والمهيمنة. كانت هناك ارتباطات غير ذات دلالة إحصائية بين أي من SNPs وMS في ظل النماذج االتي تم اختبارها<br/>الخلاصة: خلصت هذه الدراسة إلى أن تعدد الأشكال Bsm-I وFok-I لجين مستقبل فيتامين د VDR لا يرتبط بخطر الإصابة بمرض التصلب العصبي المتعدد لدى المرضى المصريات. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biochemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | كيمياء حيوية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | 25-Hydroxyvitamin D |
| -- | Multiple sclerosis |
| -- | Bsm1 polymorphism |
| -- | Fok1 polymorphism |
| -- | Vitamin D receptor |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ali El-Desouky |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Taha Abo Krysha |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Mohamed Ali El-Desouky |
| -- | Noha Taha Abo Krysha |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 29.11.2025 | 92624 | Cai01.12.02.Ph.D.2025.Am.B | 01010110092624000 | 29.11.2025 | 29.11.2025 | Thesis |