Expected role of Long non-coding RNA TCONS as Novel Biomarker in Idiopathic Thrombocytopenic Purpura / (Record no. 176938)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05551nam a22004457a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251222134233.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251222s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 574.192 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 574.192 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.02.Ph.D.2025.Mo.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mayada Mohammed Ali Mohammed El-Tarouty, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Expected role of Long non-coding RNA TCONS as Novel Biomarker in Idiopathic Thrombocytopenic Purpura / |
| Statement of responsibility, etc. | by Mayada Mohammed Ali Mohammed El-Tarouty ; Supervison Prof. Dr. Mohamed A. EL-Desouky, Prof.Dr. Nashwa Nagy Al-Khazragy, Dr. Fatma Baioumy Rashidi Abdallah. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور المتوقع للاحماض النووية الريبوزية الطويلة غير المشفرة TCONS كمؤشر بيولوجي جديد في نقص الصفائح الدموية المناعى مجهول السبب |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 148 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 128-148. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Paediatric immune thrombocytopenia (ITP) is an autoimmune condition whose cause is unclear and appears to include a number of different factors.<br/>Objectives: Evaluation of the potential value of the long non-coding RNA TCONS_00003870 and its targeted genes; hsa-let-7a-5p and SEMA4C genes in patients with idiopathic thrombocytopenic Purpura (ITP).<br/>Methods: In this investigation, quantitative real-time PCR was used to examine the expression profiles of each of the long non-coding RNA TCONS_00003870, the miRNA Let-7a-5p and mRNA SEMA4C in 70 Plasma samples from children with ITP and 30 from healthy controls (HCs). It was also examined whether they were associated with ITP clinical characteristic parameters and whether it's potential usage as a non-invasive circulating biomarker for ITP diagnosis.<br/>Results: Children with ITP had significantly decreased level of both lncRNA TCONS and m-RNA SEMA4C (expressed as fold changes) compared with controls (P < 0.00).When compared to HCs, ITP patients' levels of the miRNA Let-7a-5p were considerably higher (P < 0.0001). The two biomarkers miRNA Let-7a-5p, m- RNA SEMA4C had an excellent sensitivity (100%), for TCONS, it had a great sensitivity (98.6%).The all three markers have great specificity (87.1, 96.8 and 90.3<br/>% for TCONS, Let-7a-5p and the SEMA4C, respectively). |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | نقص الصفيحات المناعي (ITP) هو مرض مناعي ذاتي يتميز بتعداد منخفض للصفائح الدموية وزيادة خطر النزيف. يظل الحدث الأولي الذي يؤدي إلى المناعة الذاتية للصفائح الدموية غير واضح ، ولكن يوجد دليل قوي على أن العديد من عوامل الخطر الجيني )مثل التعددية في الجينات المرتبطة بالحصانة( تهيئ لـ .ITP<br/>الهدف من الدراسة: تقييم القيمة المحتملة للجينات TCONS_00003870 RNA الطويلة غير المشفرة وجيناتها المستهدفة "جينات hsa-let-7a-5p و "SEMA4C في المرضى الذين يعانون من فرفرية نقص الصفيحات الدموية مجهول السبب .(ITP)<br/>طريقة العمل: تم قياس قيمة الجينات TCONS_00003870 RNA الطويلة غير المشفرة وجيناتها<br/>المستهدفة "جينات hsa-let-7a-5p و SEMA4C فى بلازما الدم باستخدام تقنية PCR وتم تقسيم<br/>المجموعات محل الدراسة الى مجموعتين :مجموعة )أ( تتكون من 30 شخص من الاطفال الأصحاء والمجموعة )ب( تتكون من 70 شخص مصاب بنقص الصفائح الدموية مجهول السبب والتى تم تقسيمها<br/>الى مجموعتين مجموعات فرعية تبعا لشدة نقص الصفيحات الدموية )حالات نقص الصفيحات الخفيف والمتوسط.(<br/>القياسات والاستنتاج: انخفضت معدلات كلا من TCONS وSEMA4C فى بلازما الدم لمرضى نقص<br/>الصفيحات المناعي (ITP) وارتفعت معدلات let-7a-5p فى بلازما الدم لمرضى نقص الصفيحات<br/>المناعي (ITP) الذى أثبت فى هذه الدراسة انه كل منهم لديه حساسية شديدة للمرض. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biochemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | كيمياء حيوية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Immune thrombocytopenic purpura (ITP) |
| -- | long non-coding RNA |
| -- | TCONS |
| -- | microRNAs |
| -- | Let-7 |
| -- | Let-7a-5p |
| -- | SEMA4C |
| -- | لاحماض النووية الريبوزية لطويلة غير المشفرة .TCONS |
| -- | نقص الصفيحات المناعي مجهول السبب(ITP) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed A. EL-Desouky |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nashwa Nagy Al-Khazragy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fatma Baioumy Rashidi Abdallah |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Mohamed A. EL-Desouky |
| -- | Nashwa Nagy Al-Khazragy |
| -- | Fatma Baioumy Rashidi Abdallah |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 22.12.2025 | 92887 | Cai01.12.02.Ph.D.2025.Mo.E | 01010110092887000 | 22.12.2025 | 22.12.2025 | Thesis |