In vitro evaluation potential for wharton’s jelly derived mesenchymal stem cells medium and /or scorpion venom against proliferative of breast cancer cell line (MCF-7) / (Record no. 176945)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05550namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20251223104026.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251222s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 572.838 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 572.838 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.25.M.Sc.2025.Ya.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Yasmen Mohamed Said Abd El-Rahman Hassan, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | In vitro evaluation potential for wharton’s jelly derived mesenchymal stem cells medium and /or scorpion venom against proliferative of breast cancer cell line (MCF-7) / |
| Statement of responsibility, etc. | by Yasmen Mohamed Said Abd El-Rahman Hassan ; Supervisors Prof. Dr. Aly Fahmy Mohamed, Prof. Dr. Nadia Emam Aly El-Game, Dr. Said A. Ali. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التقييم المعملى للدور المحتمل لوسط الخلايا الجذعية الوسيطة المستخلصة من هلام وارتونو/او سم العقرب كمضاد لتكاثر خلايا الثدى السرطانية |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 59 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 48-56. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | The current thesis aimed to analyze the antitumor efficiency of human Wharton’s jelly-derived mesenchymal stem cells conditioning medium (hWJ-MSCs-CM)/CM or the Egyptian scorpion Leiurusquin questriatus venom (ScV) against breast cancer (MCF-7) cell line as an alternative cancer therapy. <br/>hWJ-MSCs-CM were applied to MCF-7 at different concentrations 75%, 50% in addition to25% ml. ScV toxicity was also measured, with a concentration-dependent viability percentage and an IC50 value of about 100 μg/ml. Furthermore, apoptotic activity was detected by evaluating the apoptotic genes (Casp3/9 and Bax) and genes of the anti-apoptosis (Bcl2, PKM2 and ALDOA) profiles. hWJ-MSCs-CMor L. quinquestriatus IC50 value have in-vitro anti-proliferative potential on MCF-7 through induction of apoptosis proved via arrest of cancer cells at G0-G1 and S phases, up-regulation of target pro-apoptotic genes Bax, Caspasae-3 and Caspase-9 as well as down regulation of anti-apoptotic genes Bcl-2, ALDOA and PKM2. <br/>As stated by the current thesis and additional investigations, there is a lot of confirmations that hWJ-MSCs-CM or ScV IC50 suppresses cancer cells proliferations. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | هدفت الدراسة الحالية إلى تقييم العلاجات المضادة للسرطان مثل وسط الخلايا الجذعية المستخلصة من هلام وارتون من الحبل السرى البشرى او سم العقرب المصري من فصيلة اللورياسكوينكويسترياتوس كعلاج حيوي فعال مضاد لخلايا الثدي السرطانية معمليا.<br/>تمت معالجة خلايا الثدى السرطانية بالتركيزات المختلفة من الخلايا الجذعية (25٪ و 50٪ و 75٪ مل) وايضا بتركيز قيمة الاى سى خمسون لسم العقرب (اعلى درجه سميه) والتى تساوى 100 ميكروغرام / مل. تم تتبع نشاط موت الخلايا المبرمج من خلال قياس الجينات الكابحة لخلايا السرطان مثل الباكس والكسبيس 3 و 9 وايضا الجينات المنشطة للسرطان مثل بى سى ال2 وانزيمات الالدو و البى كا ام 2 . <br/>اظهرت النتائج قدرة تاثير وسط الخلايا الجذعية المستخلصة من هلام وارتون من الحبل السرى البشرى او سم العقرب على تثبيط خلايا الثدي السرطانية معمليا من خلال تعطيل انقسام دورة الخلايا المسرطنة في مرحلتي جى 0-جى 1 و مرحلة الاس بينما تم زيادة نشاط الجينات الكابحة لخلايا السرطان مثل الباكس والكسبيس 3 و 9 وايضا تثبيط نشاط الجينات المنشطة للسرطان مثل بى سى ال2 وانزيمات الالدو و البى كا ام 2 <br/>اعتمد موت الخلايا السرطانى المبرمج على مدة وتركيز العلاجات. وفقا للدراسة الحالية و الدراسات الاخرى هناك أدلة وافرة على أن الخلايا الجذعية المستخلصة من هلام وارتون من الحبل السرى البشرى او قيمة الاى سى خمسون لسم العقرب لديهم القدرة على تثبيط خلايا الثدي السرطانية. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Biology |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | التقنية الحيوية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast Cancer |
| -- | Wharton's jelly |
| -- | Mesenchymal Stem Cells |
| -- | Conditioning Medium |
| -- | Leiurus Quinquestriatus |
| -- | Apoptosis |
| -- | سرطان الثدى |
| -- | وارتون جيلى |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aly Fahmy Mohamed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia Emam Aly El-Game |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Said A. Ali |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Aly Fahmy Mohamed |
| -- | Nadia Emam Aly El-Game |
| -- | Said A. Ali |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Biotechnology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 22.12.2025 | 92892 | Cai01.12.25.M.Sc.2025.Ya.I | 01010110092892000 | 22.12.2025 | 22.12.2025 | Thesis |