Assessing the activity of mononuclear cells isolated from egyptian ovarian cancer patients / (Record no. 177701)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05393namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260121111033.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260114s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.99465 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.99465 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.21.M.Sc.2024.No.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Nourhan Essam Mohamed Sayed Hussein, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Assessing the activity of mononuclear cells isolated from egyptian ovarian cancer patients / |
| Statement of responsibility, etc. | by Nourhan Essam Mohamed Sayed Hussein ; Supervisors Prof. Dr. Noha Ahmed Mahana, Prof. Dr. Abeer Mahmoud Badr, Dr. Auhood Abdel-Monem Ali Nassar. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم نشاط الخلايا أحاديه النواة المعزولة من مرضى سرطان المبيض المصريين |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 86 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 69-82. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Interleukins (ILs) are cytokines that play a crucial function in our <br/>immune system. Recently, the effect of ILs as immunotherapeutic targets in the <br/>treatment of cancer has occupied the attention of researchers and scientists. Recent <br/>evidence has confirmed the role of IL-18 and IL-12 in promoting the production of <br/>interferon (IFN), regulating the immune response, and enhancing the activity of <br/>natural killer (NK) cells. Both IL-18 and IL-12 more effectively stimulated NK cell <br/>degranulation and IFN- production than either IL-18 or IL-12 alone. Objectives: This <br/>study investigated the therapeutic effect of the IL-18 and IL-12 combination in <br/>stimulating PBMCs from ovarian cancer patients to evaluate its therapeutic rule. <br/>Methods: An in vivo experimental study was conducted on 24 ovarian cancer (OC) <br/>patients who were divided into 3 groups: 8 patients with benign ovarian tumors, 8 <br/>patients with low-grade OC (grades I and II), and 8 patients with high-grade OC <br/>(grades III or IV). Then, PBMCs were isolated and stimulated using a combination <br/>of IL-18 and IL-12. Finally, the production of IFN-γ and TNF-α was measured by <br/>ELISA before and after stimulation. Results: A significant difference in IFN-γ and <br/>TNF-α production was found before and after combined stimulation with IL-12 and <br/>IL-18. Conclusion: The combined stimulation of PBMCs from OC patients can be <br/>used as an immunotherapeutic target in cancer disease. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | الخلفية: الانترلوكينات هي السيتوكينات التي تلعب وظيفة حاسمة في جهاز المناعة لدينا. في الآونة الأخيرة، أصبح تأثير الإنترلوكينات كأهداف علاجية مناعية في علاج السرطان يحتل اهتمام الباحثين والعلماء. أثبتت الأدلة الحديثة دور IL-18 وIL-12 في تحفيز إنتاج IFN-γ، وتعديل الاستجابة المناعية ونشاط الخلايا القاتلة الطبيعية. تم تحفيز تحلل الخلايا القاتلة الطبيعية وإنتاج IFN-γ بشكل أكثر فعالية مع كل من IL-18 وIL-12 مقارنة بـ IL-18 أو IL-12 وحدهما. الأهداف: في هذه الدراسة تم دراسة التأثير العلاجي لـ IL-18و IL-12 مجتمعين في تحفيز PBMCs لدى مرضى سرطان المبيض، من أجل تقييم قاعدته العلاجية. الطرق: أجريت دراسة تجريبية على الجسم الحي على 24 مريضة بسرطان المبيض تم تقسيمهن إلى 3 مجموعات: 8 مريضات مصابات بورم مبيض حميد، 8 مريضات مصابات بسرطان المبيض منخفض الدرجة (الدرجة الأولى والثانية)، و8 مريضات مصابات بسرطان المبيض عالي الدرجة (الدرجة الثالثة) أو الرابع). ثم تم عزل مركبات PBMCs وتحفيزها باستخدام IL-18 وIL-12 مجتمعين. وأخيراً، تم قياس إنتاج IFN-γ وTNF-α قبل وبعد التحفيز بواسطة ELISA. النتائج: تم العثور على اختلاف كبير في إنتاج IFN-γ وTNF-α قبل وبعد التحفيز المشترك مع IL-12 وIL-18. الاستنتاج: يمكن استخدام تحفيز PBMCs لدى مرضى OC الذين يعانون من IL-12و IL-18 مجتمعين كهدف علاجي مناعي في مرض السرطان |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Ovaries Cancer |
| 651 #7 - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Geographic name | سرطان المبيض |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IL-12 |
| -- | IL-18 |
| -- | FN- γ, |
| -- | I TNF- α |
| -- | سرطان المبيض |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Ahmed Mahana |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abeer Mahmoud Badr |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Auhood Abdel-Monem Ali Nassar |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Noha Ahmed Mahana |
| -- | Abeer Mahmoud Badr |
| -- | Auhood Abdel-Monem Ali Nassar |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Zoology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 14.01.2026 | 93141 | Cai01.12.21.M.Sc.2024.No.A | 01010110093141000 | 14.01.2026 | 14.01.2026 | Thesis |