Prognostic impact of tumor associated macrophages in pediatric ewing sarcoma, National Cancer Institute; (2010-2020) / (Record no. 177967)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06651namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260203121919.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260122s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 618.92994 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 618.92994 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.19.05.Ph.D.2025.Re.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Reem Ragab Hegazy, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Prognostic impact of tumor associated macrophages in pediatric ewing sarcoma, National Cancer Institute; (2010-2020) / |
| Statement of responsibility, etc. | by Reem Ragab Hegazy ; Supervisors Prof. Mohamed Hany Mohamed Hussein, Dr. Mustafa Mohamed Selim, Dr. Mahitab Ibrahim Altohamy. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | معدل البقاء الناتج عن وجود الخلايا الاكله المرتبطه بالورم في سرطان يوينج ساركوما للاطفال خبرة المعهد القومى للاورام (2010-2020) |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 142 pages : |
| Other physical details | illustrations : |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 110-139. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Ewing sarcoma (ES) is the second most common <br/>malignant bone tumor in children and adolescents. Tumor-associated <br/>macrophages (TAMs) are a key component of the tumor <br/>microenvironment, play a central role in promoting tumor progression, <br/>metastasis and resistance to chemotherapy and radiotherapy. While <br/>increased TAM infiltration is linked to poor prognosis in various solid <br/>tumors, limited data are available regarding their role in sarcomas. <br/>Purpose: This retrospective study aimed to evaluate the frequency, <br/>density and prognostic impact of TAMs in pediatric patients with Ewing <br/>sarcoma treated at Pediatric Oncology Department, National Cancer <br/>Institute, Cairo University. <br/>Methods: Immunohistochemical analysis of CD68 and CD163 <br/>expression was performed on 74 tumor tissue samples from pediatric ES <br/>patients to assess TAM density. <br/>Results: The study cohort comprised 74 patients with a median age of 12 <br/>years (range: 0.5–18 years) and a male-to-female ratio of 0.8:1. The 5-<br/>year overall survival (OS) and event-free survival (EFS) rates were 48% <br/>and 42.8%, respectively. CD68 expression showed significant <br/>correlations with age at diagnosis (p = 0.03) and tumor size (p = 0.035). <br/>Near-significant associations were observed between CD68 levels and <br/>skeletal tumor location (p = 0.052), as well as complete response <br/>following induction chemotherapy (p = 0.054). CD163 expression was <br/>significantly associated with age at diagnosis (p = 0.04). A fair positive <br/>correlation was observed between CD68 and CD163 expression. <br/>However, neither CD68 (≤60 vs >60) nor CD163 (≤90 vs >90) levels <br/>showed significant correlation with survival outcomes (OS or EFS). <br/>Prognostic factors such as tumor site, stage, metastatic burden, response <br/>to induction chemotherapy, surgical feasibility, and histological response <br/>significantly influenced survival. Chemotherapy dose intensity (biweekly <br/>administration) showed a near-significant association with EFS (p = <br/>0.06). <br/>Conclusions: This study demonstrated relatively low survival outcomes <br/>among pediatric ES patients, consistent with data from low- and middle-<br/>income countries, and inferior to those reported in high-income settings. <br/>TAM markers (CD68, CD163) did not demonstrate a significant <br/>prognostic impact on survival. Larger-scale studies are warranted to more <br/>precisely determine the role of TAMs in pediatric Ewing sarcoma |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | الساركوما الإيوينغ هي ثاني أكثر الأورام الخبيثة شيوعًا في العظام لدى الأطفال والمراهقين. وتعد الخلايا الضامة المرتبطة بالأورام (TAMs) من المكونات الرئيسية للخلايا المناعية المتسللة إلى الورم في بيئة الورم الدقيقة، ولها دور رئيسي كمنظمين للالتهاب المرتبط بالأورام. طُرق البحث: دراسة استعادية شملت 74 مريضًا مصابًا بساركوما الإيوينغ، تم مراجعة سجلاتهم الطبية وفحص الأنسجة الخاصة بهم. تم علاج المرضى في المعهد القومي للأورام، جامعة القاهرة، خلال الفترة من 1 يناير 2010 حتى نهاية ديسمبر 2020 النتائج: خلال فترة الدراسة، توفي 34 مريضًا. كانت فترة المتابعة المتوسطة 34.4 شهرًا (تتراوح من 0.3 إلى 107 أشهر). كانت مدة البقاء على قيد الحياة العامة المتوسطة 60 شهرًا، بينما كانت نسبة البقاء على قيد الحياة العامة التراكمية بعد 3 سنوات %55.7، وفي نهاية الدراسة كانت %48. كانت نسبة البقاء على قيد الحياة دون حدث (EFS) التراكمية بعد 3 سنوات وفي نهاية الدراسة %50.6 و%42.8 على التوالي الخاتمة: وُجدت علاقة ذات دلالة إحصائية بين تعبير CD68 وكلاً من العمر وحجم الورم الأولي. بينما يظهر تعبير CD163 علاقة ذات دلالة إحصائية مع العمر فقط. هناك ارتباط إيجابي معتدل بين CD68 وCD163. لم يكن لعلامات TAMs (CD68، CD163) تأثير تنبؤي على البقاء على قيد الحياة من حيث البقاء على قيد الحياة العامة (OS) والبقاء دون حدث (EFS)… |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Tumors in children |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الأورام عند الأطفال |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ewing sarcoma |
| -- | Tumor associated macrophages |
| -- | Egypt |
| -- | Cairo University |
| -- | ساركوما إيوينغ |
| -- | الخلايا الضامة المرتبطة بالأورام |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Hany Mohamed Hussein |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mustafa Mohamed Selim |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahitab Ibrahim Altohamy |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Mohamed Hany Mohamed Hussein |
| -- | Mustafa Mohamed Selim |
| -- | Mahitab Ibrahim Altohamy |
| Universities | Cairo University |
| Faculties | National Cancer Institute |
| Department | Department of Pediatric Oncology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 22.01.2026 | 93217 | Cai01.19.05.Ph.D.2025.Re.P | 01010110093217000 | 22.01.2026 | 22.01.2026 | Thesis |