Neuroprotective effect of some antidiabetic drugs in an animal model of induced mania sleep deprivation / (Record no. 178159)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06032namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260210131856.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260203s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.32 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.32 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.09.M.Sc.2025.Na.N |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Nada Khaled Saleh Sadek, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Neuroprotective effect of some antidiabetic drugs in an animal model of induced mania sleep deprivation / |
| Statement of responsibility, etc. | by Nada Khaled Saleh Sadek ; Supervision Dr. Mohamed Farag EL Yamany, Dr. Ahmed Seif El Din Kamel. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الفاعلية الواقية للأعصاب لبعض الأدوية المضادة للسكر في نموذج هوس حيواني مستحدث بالحرمان من النوم |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 161 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 136-158. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Mania-like episodes are neuropsychiatric disturbances associated with bipolar <br/>disorder (BD). Autophagic flux disturbance evolved as one of the molecular <br/>mechanisms implicated in mania. Recently, Dapagliflozin (DAPA) has corrected <br/>autophagic signaling in several neurological disorders. Yet, no endeavours examined <br/>the autophagic impact of DAPA in mania-like behaviours. This study aimed to <br/>investigate the effect of DAPA on disrupted autophagic pathways in a mouse model <br/>of mania-like behaviour. Mania-like behaviour was induced through paradoxical <br/>sleep deprivation (PSD) using the multipleplatform method for a duration of 36 h. <br/>Mice were divided into three groups, with DAPA (1 mg/kg/day, orally) administered <br/>for one week. Behavioural assessments were conducted on the 7th day. DAPA <br/>mitigated anxiety-like behaviour in the open field test and improved motor <br/>coordination and muscle tone in the rotarod test. Mechanistically, DAPA activated <br/>hippocampal autophagy-related markers; liver kinase B1/AMP-activated protein <br/>kinase (LKB1/AMPK) pathway, autophagy related gene 7 (ATG7), and <br/>microtubule-associated protein light chain 3II (LC3II). This was associated with <br/>reduced levels of the autophagosome receptor p62 protein, which subsequently <br/>enhanced GABAA receptor-associated protein (GABARAP), facilitating the surface <br/>presentation of GABAA receptors. Additionally, DAPA upregulated the GABAB <br/>receptor R2 subunit through trophic factors such as brain-derived neurotrophic factor <br/>(BDNF) and glial cell line-derived neurotrophic factor (GDNF). Furthermore, <br/>DAPA mitigated elevated serum stress hormones and restored the balance between <br/>proinflammatory and anti-inflammatory cytokines in both cortical and hippocampal <br/>tissues. These findings highlight the role of autophagic flux modulation by DAPA <br/>and its therapeutic potential in mitigating mania-like behaviours. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | الدور العصبي الجزيئي للدواء داباجليفلوزين (Dapagliflozin - DAPA) في علاج اضطرابات الهوس مرتبط بتأثيره على مسارات التحلل الذاتي (Autophagic flux) في الدماغ، وهو آلية خلوية تلعب دوراً مهماً في الحفاظ على صحة الخلايا العصبية. في دراسة حديثة على نموذج فأري للهوس الشبيه بالمانيا، تم تحريض سلوكيات هيسترية تشبه الهوس عن طريق حرمان الفئران من النوم العميق لمدة 36 ساعة. بعد ذلك، عولجت الفئران بداباجليفلوزين لمدة أسبوعأظهرت النتائج أن داباجليفلوزين قلل من سلوكيات القلق وطور التنسيق الحركي وقوة العضلات عند الفئران. على المستوى الجزيئي، نشط الدواء علامات متعلقة بعملية التحلل الذاتي مثل مسار LKB1/AMPK، وجين ATG7، والبروتين LC3II، مع انخفاض في مستوي بروتين p62 المرتبط بالأوتوفاجوسومات، مما ساعد على زيادة بروتين مرتبط بمستقبلات GABA (GABARAP) وبالتالي تعزيز ظهور مستقبلات GABA-A على سطح الخلايا العصبية. علاوة على ذلك، زاد داباجليفلوزين من تعبير وحدة المستقبل GABA-B R2 عبر عوامل غذائية عصبية مهمة مثل BDNF وGDNF. كما خفف الدواء من ارتفاع هرمونات التوتر في المصل وأعاد التوازن بين السيتوكينات المؤيدة والمضادة للالتهاب في أنسجة الدماغ . باختصار، داباجليفلوزين يعيد توازن مسارات التحلل الذاتي العصبية ويعزز وظائف النظام الاستيتيابي الغازي (GABAergic system)، مما يسهم في تخفيف سلوكيات الهوس الشبيه بالمانيا في نموذج حيواني، مما يفتح آفاقاً جديدة لعلاجه ضمن اضطرابات ثنائية القطب المرتبطة بالهوس. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmacology & Toxicology |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الأدوية والسموم |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Autophagic flux |
| -- | Dapagliflozin |
| -- | GABA |
| -- | HPA axis |
| -- | PSD |
| -- | Mania-like behaviour |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Farag EL Yamany |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Seif El Din Kamel |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Mohamed Farag EL Yamany |
| -- | Ahmed Seif El Din Kamel |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmacology & Toxicology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 03.02.2026 | 93283 | Cai01.08.09.M.Sc.2025.Na.N | 01010110093283000 | 03.02.2026 | 03.02.2026 | Thesis |