The impact of nuclear unrest in outcome of pediatric unilateral wilms tumor with favorable histology : (Record no. 178238)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 05591namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260215101520.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260207s2023 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 618.9215 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 618.9215 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.19.05.Ph.D.2023.Am.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Aml Mahmoud A.Elgaml, |
| Preparation | preparation. |
| 245 14 - TITLE STATEMENT | |
| Title | The impact of nuclear unrest in outcome of pediatric unilateral wilms tumor with favorable histology : |
| Remainder of title | at national cancer institute – Cairo university / |
| Statement of responsibility, etc. | by Aml Mahmoud A.Elgaml ; Supervision Prof. Dr. Iman Sidhom, Prof. Dr. Hoda Ismail, Prof. Dr. Wael Zekri Khaled, Prof. Dr. Manal El-Baradie. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير الاضطرابات النووية على نتائج اورام الويلمز من نوع الأنسجة المواتية فى جهة واحده من الكلى عند الاطفال : |
| Remainder of title | المعهد القومي للأورام – جامعة القاهرة |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 109 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 95-109. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background and Aim: <br/> Nuclear unrest is a term applied to Wilms tumors (WT) with favorable histology that show <br/>nuclear enlargement similar to that seen in anaplasia but with no abnormal mitotic figures. This <br/>study aimed to find out the impact of nuclear unrest grades on unilateral favorable histology <br/>Wilms tumor (FHWT). <br/>Patients and Methods: This retrospective study included 62 patients with unilateral favorable <br/>histology Wilms tumor at National Cancer Institute-Egypt (median age 40 months) treated <br/>from January 2008 to December 2017. <br/>Results: Among 62 patients with pathologically confirmed FHWT, 17(27.4%) patients were <br/>found to have no nuclear unrest (grade 0), 13 (21%) patients had grade I, 13 (21%) patients had <br/>grade II and 19 (30.6%) patients had grade III nuclear unrest. Nuclear unrest grade 3 were more <br/>common in patient’s age ≥5 years (p=0.03), and predominated in patients who underwent <br/>upfront nephrectomy (p=0.01), however, gender, stage distribution and response to treatment <br/>were similar to that for WT with other grades of nuclear unrest. Estimated 4-year event-free <br/>survival (EFS) and overall survival (OS) of the study were 81.8%±5% and 86.4% ±4.5%. <br/>Nuclear unrest grade 2 and 3 grouped together had statically significant lower EFS versus grade <br/>0 and 1, 71%, 93.3% respectively (p = 0.029). multivariate analysis revealed that metastatic <br/>disease and nuclear unrest grade 2 -3 were an independent prognostic factor for EFS. p= 0.003 <br/>with HR 7.2 (95.0% CI :1.5-34.1) for metastatic disease and P= 0.013 with HR 6.8 (95.0% CI: <br/>1.9 -23.8) for nuclear unrest grade2-3. Metastatic disease at diagnosis was prognostic for OS <br/>(p =<0.001). <br/> Conclusions: Metastatic disease at diagnosis clearly remains the most important prognostic <br/>factor in unilateral FHWT. Nuclear unrest grade 2 and 3(grouped together) adversely affect <br/>EFS in unilateral FHWT. Larger analysis will be necessary to consolidate our results. <br/>Ultimately, international harmonization and clarification of definition of nuclear unrest grades <br/>may help precise grading and consequently, treatment modification for better survival. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | الاضطرابات النووية هو مصطلح ينطبق على أورام ويلمز ذات الأنسجة المواتية التي تظهر تضخمًا نوويًا مشابهًا لذلك الذي يظهر في فقدان التنسج ولكن مع عدم وجود أرقام انقسامية غير طبيعية. هدفت هذه الدراسة إلى معرفة تأثير درجات الاضطرابات النووية على الأنسجة المواتية لورم ويلمز, <br/>تم اجراء هذه الدراسة علي عدد 62 طفلا مصابين باورام الكلي علي احد الجانبين والذين تم تشخيصهم طبقا لنتائج تحليل الانسجة (خاصة نتائج الأنسجة المفضلة) وذلك بقسم اروام الأطفال بالمعهد القومي للسرطان في مصر في الفترة خلال الفترة من يناير 2008 إلى ديسمبر 2017بالاضافة الي تقييم المرضى لمعرفة تأثير الاضطرابات النووية الخاصة بالخلايا بالنسبة البقاء على قيد الحياة بصفة عامة و البقاء علي قيد الحياة من بداية العلاج و لحين حدوث تطور وعلاقتهم بعوامل تطور المرض . |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pediatric Oncology |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | اورام الأطفال |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pediatric favorable histology Wilms tumor |
| -- | nuclear unrest |
| -- | survival |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman Sidhom |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoda Ismail |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wael Zekri Khaled |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manal El-Baradie |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2023 |
| Supervisory body | Iman Sidhom |
| -- | Hoda Ismail |
| -- | Wael Zekri Khaled |
| -- | Manal El-Baradie |
| Universities | Cairo University |
| Faculties | National Cancer Institute |
| Department | Department of Pediatric Oncology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 07.02.2026 | 93306 | Cai01.19.05.Ph.D.2023.Am.I | 01010110093306000 | 07.02.2026 | 07.02.2026 | Thesis |