Role of Pentraxin 3 and Doppler ultrasound in assessing the severity of endothelial dysfunction in patients on regular hemodialysis in comparison with chronic kidney disease patients stage 5 not on renal replacement therapy / (Record no. 178340)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06927namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260219110917.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260210s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.61 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.61 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.18.Ph.D.2024.Ba.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Basma Abd El-Aziem Zaghloul Mohamed, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Role of Pentraxin 3 and Doppler ultrasound in assessing the severity of endothelial dysfunction in patients on regular hemodialysis in comparison with chronic kidney disease patients stage 5 not on renal replacement therapy / |
| Statement of responsibility, etc. | by Basma Abd El-Aziem Zaghloul Mohamed ; Supervised Prof. Mohamed Mostafa Elkhati, Prof. Amr Mohamed Shaker, Dr. Heba Mahmoud Ibrahim, Prof. Tarek Ramzy Abd El-Aziem. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور البنتراكسين 3 والدوبلر في تقييم شدة الخلل البطاني لدى مرضى الغسيل الكلى المنتظم مقارنة مع مرضى القصور الكلوي المزمن في المرحلة الخامسة الذين لا يخضعون لغسيل الكلى |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 130 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 100-129. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Endothelial dysfunction (ED) is a major contributor to the pro-<br/>inflammatory state, as well as a leading cause of subclinical atherosclerosis and <br/>consequently, cardiovascular disease, which is primary cause of death in end stage <br/>renal disease population. Pentraxin3 (PTX3) is a potential biomarker of vascular <br/>inflammation in addition to measuring Flow mediated dilatation of brachial artery <br/>(FMD)%, and carotid intima media thickness (CIMT) are noninvasive techniques in <br/>assessing endothelial dysfunction. <br/>Aim: <br/>Evaluating the significance of serum PTX 3, FMD%, and CIMT in identifying en-<br/>dothelial dysfunction in patients with stage 5 chronic kidney disease who are not r-<br/>eceiving renal replacement therapy in comparison to hemodialysis patients. <br/>Methods: a prospective cross-sectional study with 150 individuals overall, <br/>classified into 3 groups: 50 individuals for each group: i) Control group; ii) CKD <br/>group (stage 5 not on renal replacement therapy); and iii) Dialysis group. All of them <br/>were subjected to clinical assessment, laboratory measurements of lipid profile, <br/>calcium, phosphorus, PTH as well as serum PTX3. Additionally, Doppler <br/>ultrasonography was used to assess CIMT, FMD%, and flow volume. <br/>Results: According to our results, PTX3 level was significantly higher in CKD and <br/>dialysis patients compared to controls; moreover, its level is higher in dialysis <br/>patients compared to CKD with p <0.001. The FMD% and its flow volume were <br/>significantly lower, while the CIMT was significantly higher in CKD and dialysis <br/>patients compared to controls; furthermore, the FMD% and its flow volume were <br/>lower in CKD compared to dialysis patients, with a p-value of <0.001.PXT3 showed <br/>significant negative correlation with FMD% and its flow volume and positive <br/>correlation with CIMT. Based on the suggested cut-off on ROC curve and its area <br/>under curve, PTX3, FMD% had a high sensitivity (82% and 80% respectively) and <br/>high specificity (75%, and 85% respectively) <br/>Conclusion: High levels of PTX3, low FMD%, and increased CIMT play a crucial <br/>role in assessing endothelial dysfunction in CKD and dialysis patients. Furthermore, <br/>we hypothesized that dialysis may improve the endothelial dysfunction, which is <br/>confirmed by higher PTX3 and lower FMD% in CKD compared to dialysis patients. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | يعد القصورالكلوي المزمن مشكلة صحية عالمية كبرى تؤثر على أكثر من 13% من البالغين في العالم. في مرضى الكلى المزمن ،و تمثل مرض القلب والأوعية الدموية السبب الرئيسي للحالات المرضية المصاحبة للقصور الكلوي وسبب الوفاة الأكثر أهميةز من الفشل الكلوي نفسه. يلعب خلل بطانة الأوعية الدموية دورًا مهمًا في نشوء تغيرات فسيولوجية متعددة و ارتفاع نسبة المواد المعززة للالتهابات التي تزيد في حالات القصور الكلوي و التي تساهم بشكل اساسي في حدوث امراض القلب و الأوعية الدموية. <br/>لقد برز قياس وظيفة بطانة الأوعية الدموية كأداة قيمة تعكس التغيرات الفسيولوجية التي تؤدي الي حدوث امراض القلب و الأوعية الدموية و قد تتنبأ بحدوث هذه الامراض بشكل مبكر . إن قياس التمدد الناتج عن التدفق هو نهج غير تداخلي يعكس وظيفة الشرايين المعتمدة على بطانة الأوعية الدموية والتي تعتمد إلى حد كبير على أكسيد النيتريك وقد تم استخدامه كأداة قياس لصحة الأوعية الدموية. علاوة على ذلك، فإن قياس إن تقييم التمدد الناتج عن التدفق هو أداة لفحص الفيسيولوجيا المرضية للأمراض القلبية الوعائية وربما تحديد الأشخاص المعرضين لخطر متزايد لأمراض القلب و الأوعية الدموية. و يلعب البنتراكسين 3 دورًا مهما في الاستجابة المناعية و له تأثير كوسيط لحدوث تغيرات تؤثر على فسيولوجيا نظام القلب والأوعية الدموية من خلال مجموعة متنوعة من الظواهر مثل الالتهاب، وتولد الأوعية، وتكون الأورام، والتصاق الخلايا.. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Internal Medicine |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | أمراض الكلى |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | pentraxin |
| -- | FMD |
| -- | carotid intima media thickness |
| -- | chronic kidney disease |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Mostafa Elkhati |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amr Mohamed Shaker |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Mahmoud Ibrahim, |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarek Ramzy Abd El-Aziem |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Mohamed Mostafa Elkhati |
| -- | Amr Mohamed Shaker |
| -- | Heba Mahmoud Ibrahim |
| -- | Tarek Ramzy Abd El-Aziem |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Internal Medicine |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 10.02.2026 | 93338 | Cai01.11.18.Ph.D.2024.Ba.R | 01010110093338000 | 10.02.2026 | 10.02.2026 | Thesis |