Synthesis, molecular docking studies and biological evaluation of some unsaturated carbonyl derivatives / (Record no. 178425)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05168namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260223121229.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260213s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| Language of cataloging | eng |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 547.036 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 547.036 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.02.M.Sc.2025.Ra.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Rahma Ali Abdelghany, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis, molecular docking studies and biological evaluation of some unsaturated carbonyl derivatives / |
| Statement of responsibility, etc. | by Rahma Ali Abdelghany ; Supervisors Prof. Dr. Ismail Abdelshafy Abdelhamid, Dr .Nada Sabry Ibraheem Abd Elhady, Dr.Marwa Mohamed Mohamed Ahmed Sharaky. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير وتقييم بيولوجي لبعض مشتقات الكربونيل الجديدة غير المشبعة كعوامل مضادة للسرطان |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 93 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 82-92. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | To produce more effective anticancer medicines, a variety of new 2-arylideneindane-1,3-dione scaffolds were developed and synthesized by molecular hybridization. The base-catalyzed Knoevenagel reaction of 2-(4-formylphenoxy)-N-arylacetamides with 1,3-indandione produced good yields of the desired products. The structural features of the novel compounds were validated using spectrum and elemental analysis. The cytotoxic effect of the prepared compounds were determined against several human cancer and normal cell lines. It was found that compounds 5d and 5e exerted the most promising cytotoxic activity against Hela cells with IC50 (4.8 and 5 μg/mL, respectively) relative to doxorubicin (5 μg/mL). The molecular studies showed that compounds 5d and 5e decreased the expression level of Antigen kiel 67 (KI-67), Protein kinase B (AKT), Survivin, Interleukin-6 (IL-6), Interleukin-1beta (IL-1B), and Cyclooxygenase-2 (COX-2) genes in Hela treated cells. In addition, the activity of Glutathione (GSH), Caspase-9, Caspase-8, Caspase-3, P53, and BAX were significantly enhanced and Bcl2, Malondialdehyde (MDA), and IL-6 were suppressed in 5d and 5e treated Hela cells. Compounds 5d and 5e arrested the cell cycle at G0/G1 phase and decreased the migration ability of Hela cells to close the scratch gap after 48 h. Molecular docking study supported our ELISA results, where compounds 5d and 5e showed promising binding energy scores against P53 cancer mutant Y220C and Bcl2. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | لقد تم إنشاء سته شالكونات جديدة، وتم استخدام العديد من التقنيات الطيفية لتحديد بنيتها. لقد تم اختبار كل مركب مُصنَّع للتأكد من سميته للخلايا ضد العديد من خطوط الخلايا السرطانية، وأظهر مركبات 5d & 5eافضل النتائج ضد HELA. لقد اوضح تفاعل البوليميراز المتسلسل للنسخ العكسي أن استخدام مركب 5d & 5e له تأثير مثبط على مستويات التعبيرالجينى لجينات ki67، وsurvivin، وIL-1B، وIL-6، وCOX-2، وAKT1. لقد قاطع المركب 5d & 5e دورة الخلية في مرحلة G0/G1 في الخلايا المعالجة HELA على التوالي وفقًا لتحليل التدفق الخلوي لدورة الخلية. تم ملاحظه زياده نشاط Caspase 8،Caspase 9 ، P53، BAX و GSH بشكل كبير وتثبيط ، BCL2، MDA و IL-6 في خلايا HELA المعالجة بـ 5d & 5e وفقًا لفحص ElISA (المقايسة الامتصاصية المناعية للانزيم المرتبط ). و أظهرفحص التئام الجروح بعد 48 ساعة من المعالجه أن شالكون 5d & 5e قلل من عدد خلايا HELA المهاجرة الي مكان الجرح والقدرة على إغلاق جرح الكشط مقارنةً بالخلايا الغير المعالجة. لقد تم التحقق من صحة بيانات الاليزا الخاصة بنا من خلال النمذجة الجزيئية النظرية ضد طفرات سرطان P53 Y220C وBCL2. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Carbonyl compounds |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | مشتقات الكربونيل |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chalcones |
| -- | Anti-proliferative |
| -- | Anti-oxidant |
| -- | Anti-inflammatory |
| -- | Cell cycle arrest |
| -- | Anti-metastatic. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ismail Abdelshafy Abdelhamid |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nada Sabry Ibraheem Abd Elhady |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Mohamed Mohamed Ahmed Sharaky |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Ismail Abdelshafy Abdelhamid |
| -- | Nada Sabry Ibraheem Abd Elhady |
| -- | Marwa Mohamed Mohamed Ahmed Sharaky |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 13.02.2026 | 93357 | Cai01.12.02.M.Sc.2025.Ra.S | 01010110093357000 | 13.02.2026 | 13.02.2026 | Thesis |