Design, synthesis and evaluation of novel heterocyclic compounds having antihypertensive activity / (Record no. 178483)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04284namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260225103312.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260215s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.19 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.04.Ph.D.2025.Ma.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Marian Wagdy Aziz Yacoub, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and evaluation of novel heterocyclic compounds having antihypertensive activity / |
| Statement of responsibility, etc. | Marian Wagdy Aziz Yacoub ; Supervision Prof. Dr. Khaled Omar Ahmed Mohamed, Prof. Dr. Zeinab Mohamed Fahmy Abd Elbaky Mahmoud, Dr. Doaa Boshra Farag, Dr. Amira Karam Khalifa. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم، تشييد و تقييم مركبات حلقية غير متجانسة جديدة لها نشاط مضاد لأرتفاع ضغط الدم |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 87 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 83-84. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | The thesis consists of four chapters in addition to Arabic and English summaries and conclusion followed by some recommendations.<br/>The first chapter; General introduction about hypertension, antihypertensive drugs and heterocyclic based compounds utilized in hypertension treatment.<br/>The second chapter; Effective scaffolds as antihypertensive agents, a long story with happy endings; a review tracing the promising reported candidates.<br/>The third chapter; Synthesis of potent vasodilating agents: in silico and in vitro evaluation of 6-(4-substitutedphenyl)-3-pyridazinone derivatives as potential hydralazine analogues.<br/>The fourth chapter; Design, Synthesis and Characterization of Novel Pyridazin-3-one Derivatives: In Vitro VasorelaxantActivity and In Silico Insights into eNOS Modulation. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | تتكون الرسالة من أربعة فصول بالإضافة إلى ملخصين باللغتين العربية والإنجليزية، يليهما الخاتمة وبعض التوصيات.<br/>الفصل الأول: مقدمة عامة حول ارتفاع ضغط الدم، وأدوية علاج ارتفاع ضغط الدم، والمركبات الحلقية غير المتجانسة المستخدمة في علاج ارتفاع ضغط الدم.<br/>- الفصل الثاني: الهياكل الفعالة كعوامل مضادة لارتفاع ضغط الدم، قصة طويلة بنهايات سعيدة؛ مراجعة تتبع المرشحين الواعدين الذين تم الإبلاغ عنهم.<br/>- الفصل الثالث: تشييد عوامل موسعة للأوعية الدموية ذات فعالية عالية: التقييم الحاسوبي والتجريبي لمشتقات 6-(4-فينيل مستبدل)-3-بيريدازينون كبدائل محتملة للهيدرالازين.<br/>الفصل الرابع: تصميم وتشييد وتوصيف مشتقات جديدة من بيريدازين-3-ون: دراسة نشاطها كموسع للأوعية الدموية في التجارب المختبرية والرؤى الحاسوبية حول تعديل إنزيم eNOS. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmaceutical Organic Chemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | الكيمياء العضوية الصيدلية |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hypertension |
| -- | Antihypertensive activity |
| -- | Pyridazinones |
| -- | Molecular Modeling |
| -- | ارتفاع ضغط الدم |
| -- | النشاط المضاد لإرتفاع ضغط الدم |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khaled Omar Ahmed Mohamed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zeinab Mohamed Fahmy Abd Elbaky Mahmoud |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doaa Boshra Farag |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amira Karam Khalifa |
| Relator term | Translator. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Khaled Omar Ahmed Mohamed |
| -- | Zeinab Mohamed Fahmy Abd Elbaky Mahmoud |
| -- | Doaa Boshra Farag |
| -- | Amira Karam Khalifa |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmaceutical Organic Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 15.02.2026 | 93380 | Cai01.08.04.Ph.D.2025.Ma.D | 01010110093380000 | 15.02.2026 | 15.02.2026 | Thesis |