Assessment of left ventricular function and its association with intrarenal arterial resistance in pre-diabetic and recently diagnosed uncomplicated type 2 diabetic patients / (رقم التسجيلة. 178856)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 05843namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260311115932.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260303s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.462061 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.462061 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.18.Ph.D.2025.Ah.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Ahmed Atef Mohammed Elsayed Metwally, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of left ventricular function and its association with intrarenal arterial resistance in pre-diabetic and recently diagnosed uncomplicated type 2 diabetic patients / |
| Statement of responsibility, etc. | by Ahmed Atef Mohammed Elsayed Metwally ; Supervised Prof. Dr. Hemmat Elewa El- Haddad, Prof. Dr. Ahmed Mohammed Fayed, Prof. Dr. Moataz Fathy Mohammed, Prof. Dr. Heba Moustafa Eldeeb. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم وظيفة البطين الأيسر وارتباطها بمقاومة الشرايين داخل الكلى لدى مرضى ما قبل السكري و مرضي السكري من النوع الثاني الغير مصحوب بمضاعفات و الذين تم تشخيصهم حديثا |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 158 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 126 -158. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background: Early dysglycemia, including pre-diabetes and early Type 2 Diabetes <br/>Mellitus (T2DM), triggers oxidative stress, causing endothelial dysfunction, intra-<br/>renal arterial stiffness, and subclinical cardiac issues such as myocardial ischemia and <br/>fibrosis, even without epicardial artery disease. Advanced imaging techniques can <br/>detect these subtle changes. <br/>Aim: To evaluate left ventricular (LV) and left atrial (LA) function using Tissue <br/>Doppler Imaging (TDI) and 2D Speckle Tracking Echocardiography (2D STE), and <br/>their relationship with intra-renal artery compliance assessed by renal power Doppler <br/>ultrasonography in early dysglycemia. <br/>Mehtods: This observational case-control study, conducted at Kasralainy Hospitals <br/>from December 2023 to February 2025, enrolled 180 participants: 60 recently <br/>diagnosed T2DM patients (≤2 years), 60 pre-diabetic individuals (per ADA 2024 <br/>criteria), and 60 healthy controls, aged 18–50, normotensive, and matched for age, <br/>gender, BMI, and waist circumference. Assessments included glycemic profile <br/>(fasting blood sugar, 75g OGTT, HbA1c), lipid profile, urinary albumin-to-creatinine <br/>ratio (ACR), echocardiographic parameters via 2D STE, and renal arterial indices, <br/>particularly Renal Resistance Index (RI), via renal power Doppler ultrasound. <br/>Results: Compared to controls, T2DM and pre-diabetic groups had significantly <br/>higher eGFR, total cholesterol, triglycerides, LDL, and diastolic dysfunction (grades I <br/>and II) (P<0.05). Despite normal ranges, both groups showed impaired diastolic <br/>indices (higher E/e, lower MV E/A ratio, lower LA strain) and systolic indices (lower <br/>ejection fraction, global longitudinal strain [GLS]) (P<0.05). Renal RI was <br/>significantly elevated in both groups, with T2DM showing higher values than pre-<br/>diabetics (P<0.05). Glycemic markers and ACR correlated positively with E/e and RI <br/>and negatively with LA strain and GLS (P<0.05). RI positively correlated with E/e <br/>and negatively with septal S, indicating a link between diastolic/systolic impairment <br/>and renal arterial resistance. <br/>Conclusion: Despite normal range, Compared to controls, early T2DM & Pre-<br/>diabetic groups showed significantly impaired left atrial & ventricular diastolic & <br/>systolic indices paralleled with increased intrarenal arterial resistance. Worsening of <br/>these cardiac and renal indices correlate with dysglycemic markers & Albuminuria; <br/>hence early T2DM &pre-diabetes are associated with subclinical LV, LA dysfunction <br/>and renal arterial stiffness. So, early 2D STE and Renal artery power Doppler <br/>screening may identify at-risk individuals, enabling timely intervention to prevent <br/>cardiac & renal complications. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | هدفت هذه الدراسة إلى تقييم وظائف البطين الأيسر والأذين الأيسر باستخدام تخطيط صدى القلب بتتبع النقاط ثنائي الأبعاد وارتباطها بطواعية الشرايين داخل الكلى لدى ستين فردًا في مرحلة ما قبل السكري، وستين فردًا تم تشخيصهم حديثًا بمرض السكري من النوع الثاني (مدة المرض سنتان أو أقل)، وستين فردًا أصحاء متطابقين في العمر والجنس، تتراوح أعمارهم بين ثمانية عشر إلى خمسين عامًا، وهم غير مصابين بارتفاع ضغط الدم وبدون أمراض مصاحبة، ومتطابقين في مؤشر كتلة الجسم ومحيط الخصر. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Diabetes |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | داء السكري |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Prediabetes |
| -- | T2DM |
| -- | LV dysfunction |
| -- | renal stiffness |
| -- | 2D STE |
| -- | GLS |
| -- | renal Doppler |
| -- | RI |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hemmat Elewa El- Haddad |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Mohammed Fayed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Moataz Fathy Mohammed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Moustafa Eldeeb |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Hemmat Elewa El- Haddad |
| -- | Ahmed Mohammed Fayed |
| -- | Moataz Fathy Mohammed |
| -- | Heba Moustafa Eldeeb |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Internal Medicine |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | المكتبة المركزبة الجديدة - جامعة القاهرة | 03.03.2026 | 93485 | Cai01.11.18.Ph.D.2025.Ah.A | 01010110093485000 | 03.03.2026 | 03.03.2026 | Thesis |