Management of inoperable glioblastoma multiforme (GBM) / (Record no. 179041)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06321namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260409125135.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260315s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.99481 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.99481 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.20.M.Sc.2024.Mo.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mohamed Ahmed Mohamed Qassem, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Management of inoperable glioblastoma multiforme (GBM) / |
| Statement of responsibility, etc. | by Mohamed Ahmed Mohamed Qassem ; Supervision Prof. Dr. Mohamed Hamdy El Sissy, Prof. Dr. Mohamed Amr El-Taieb, Dr. Mohamed Hussein Mohamed Ali, Prof. Dr. Rabab Ahmed Abd El-Minaem. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | طرق تشخيص و علاج ورم المخ الارومى الدبقي الغير جراحي |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 125 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 99-123. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Background - Glioblastoma (GBM) is a highly malignant brain tumor with poor survival and prognosis. Randomized trials have demonstrated that chemotherapy improves survival in patients with GBM. <br/>Aim - to determine inoperable GBM candidates and outcomes of the used modality of treatment. <br/>Patients and Methods - In this randomized clinical trial study that was conducted in the period from jan 2023 to feb 2024 on 28 cases with newly diagnosed GBM and not candidates for surgical debulking in Neurosurgery department of kasr El-Aini University Hospital.Daily Temozolamide chemotherapy (75mg/m2×40-49days) is added concomitantly to radiotherapy followed by 6 cycles of maintenance Temozolamide (150-200mg/m2×5/28days) and the outcome of the modality of treatment used was evaluated clinically and radiologically at 3,6,9,12 months of treatment.<br/>Results - The t-test analysis revealed high statistically significant difference in lesion regarding pre-treatment lesion volume (p = 0.0001*) and post-treatment lesion volume (p = 0.0001*). The t-test analysis revealed high statistically significant difference in lesion regarding pre-treatment karnofesky score(p = 0.0001*) and post-treatment karnofesky score (p = 0.0001*). There was positive correlation between age and pre-treatment lesion volume and pre-treatment Karnofesky score (r= .941, p <.001), post-treatment lesion volume and post-treatment Karnofesky score. There was positive correlation between post-treatment lesion volume and post-treatment Karnofesky score (r= .885, p < .001) and negative correlation between age and post-treatment Karnofesky score (r = -0.021, p > 0.650).<br/>Conclusion – After receiving concomitant adjuvant radiotherapy and chemotherapy our study observed that there was significant decrease in post-treatment lesion volume and post-treatment karnofesky score. There was positive correlation between age and pre-treatment lesion volume and pre-treatment Karnofesky score, post-treatment lesion volume and post-treatment Karnofesky score and negative correlation between age and post-treatment Karnofesky score. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | مقدمة:<br/>الورم الأرومي الدبقي هو الورم الأساسي الخبيث الأكثر شيوعًا في الجهاز العصبي المركزي، مع تحسن سيئ على الرغم من العديد من العلاجات المتاحة، بما في ذلك الجراحة والعلاج الإشعاعي والعلاج الكيميائي. يعد تقييم الاستجابة للعلاج أمرًا ضروريًا لتحسين نتائج المرضى. <br/>الهدف من هذه الدراسة:<br/>تهدف دراستنا إلى تحديد المرشحين للورم الأرومي الدبقي غير الصالح للجراحه ونتائج طريقة العلاج المستخدمة.<br/>منهجية الدراسة:<br/>في دراسة تجريبية سريرية عشوائية أجريت في الفترة من يناير ٢٠٢٣ إلى فبراير ٢٠٢٤ على ٢٨ حالة مصابة بالورم الأرومي الدبقي المشخص حديثًا والذين لم يكونوا مرشحين للاستئصال الجراحي في قسم جراحة المخ والأعصاب بمستشفى جامعة القصر العيني.<br/>النتائج:<br/>لم يكن هناك فرق كبير بين عمر وجنس المرضى المشمولين في الدراسة. بلغت نسبة أسباب عدم القدرة على الجراحه المتضمنة بين المرضى الذين شملتهم الدراسة ٥ (١٧.٨٥ %) لمناطق المخ البليغه، و١٨ (٦٤.٣٠ %) لرفض الجراحه و٥ (١٧.٨٥ %) لعدم اللياقة البدنية، ولم يكن هناك فرق كبير بين جنس المجموعة.<br/>في الختام:<br/>لاحظت دراستنا أنه كان هناك انخفاض كبير في حجم الورم بعد العلاج ودرجة كارنوفسكي بعد العلاج. كان هناك ارتباط إيجابي بين العمر وحجم الورم قبل العلاج ودرجة كارنوفسكي قبل العلاج , وحجم الورم بعد العلاج ودرجة كارنوفسكي بعد العلاج ، وارتباط سلبي بين العمر ودرجة كارنوفسكي بعد العلاج. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Glioblastoma multiforme |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ورم المخ الارومى الدبقي |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | GBM |
| -- | Karnofesky score |
| -- | MRI |
| -- | Radiotherapy |
| -- | chemotherapy |
| -- | تشخيص |
| -- | ورم المخ الارومى الدبقي |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Hamdy El Sissy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Amr El-Taieb |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Hussein Mohamed Ali |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rabab Ahmed Abd El-Minaem |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025. |
| Supervisory body | Mohamed Hamdy El Sissy |
| -- | Mohamed Amr El-Taieb |
| -- | Mohamed Hussein Mohamed Ali |
| -- | Rabab Ahmed Abd El-Minaem |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Neurosurgery |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 15.03.2026 | 93579 | Cai01.11.20.M.Sc.2024.Mo.M | 01010110093579000 | 15.03.2026 | 15.03.2026 | Thesis |