MARC details
| 000 -LEADER |
|---|
| fixed length control field |
05672namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GICUC |
| 005 - أخر تعامل مع التسجيلة |
|---|
| control field |
20260315211330.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
260315s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloguing agency |
EG-GICUC |
| Transcribing agency |
EG-GICUC |
| Modifying agency |
EG-GICUC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract |
eng |
| -- |
ara |
| 049 ## - Acquisition Source |
|---|
| Acquisition Source |
Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
630.24 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) |
|---|
| Classification number |
630.24 |
| Edition number |
21 |
| 097 ## - Degree |
|---|
| Degree |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Local Call Number |
Cai01.07.04.Ph.D.2025.Me.B |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Authority record control number or standard number |
Mervat Hassan Hassan Shehata, |
| Preparation |
preparation. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Biological evaluation of avocado pulp and seeds extracts / |
| Statement of responsibility, etc. |
by Mervat Hassan Hassan Shehata ; Supervisors Dr. Samir Abdel Moneim Ahmed, Dr. Ebtesam Abdel Moneim Mahmoud, Dr. Doha Abdou Mohamed. |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
التقييم البيولوجى لمستخلاصات لب وبذور الأفوكادو |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
2025. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
158 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
25 cm. + |
| Accompanying material |
CD. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Source |
rda content |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
Unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
volume |
| Source |
rdacarrier |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D)-Cairo University, 2025 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Bibliography: pages 125-158. |
| 520 #3 - SUMMARY, ETC. |
|---|
| Summary, etc. |
Avocado is a fruit rich in oil and valued for its pleasant sensory qualities, high nutritional <br/>content, and health-promoting properties due to its abundance of bioactive compounds. This <br/>study aimed to evaluate the antioxidant, anti-cancer, and anti-arthritic activities of acetone <br/>extracts derived from the pulp, peel, and seed of avocado. Additionally, the study assessed the <br/>total phenolic and flavonoid content, fatty acid profiles, phytosterols, and hydrocarbon of these <br/>extracts. Antioxidant activity was measured using DPPH, ABTS, and FRAP assays. The anti-<br/>cancer effects of the extracts were tested on various cancer cell lines, including liver, colorectal, <br/>and breast cancer. The anti-arthritic potential of the avocado pulp extract was evaluated using <br/>the adjuvant-induced arthritis (AIA) model in rats. Gas chromatography-mass spectrometry <br/>(GC-MS) was used to characterize the extracts. The analysis revealed that the acetone extracts <br/>of pulp, peel, and seed contained total phenolic contents of 58.6, 92.9, and 91.8 mg GAE/g <br/>extract, respectively, and total flavonoid contents of 10.8, 15.1, and 12.8 mg QE/g extract, <br/>respectively. Hydrocarbons accounted for 79.06% in pulp, 91.5% in peel, and 68.93% in seed <br/>extracts. Total phytosterol content was 8.63% in pulp, 4.17% in peel, and 9.03% in seed <br/>extracts, with stigmasterol being the predominant phytosterol in all samples. The fatty acid <br/>profile showed oleic acid as the dominant unsaturated fatty acid across all extracts. <br/>GC-MS analysis identified the presence of acetogenins, volatile compounds, phytosterols, and <br/>triterpenoids in all extracts. All samples exhibited antioxidant activity across the assays used, <br/>with varying degrees of potency. The acetone extracts of pulp, peel, and seed demonstrated anti-<br/>cancer activity against liver, breast, and colorectal cancer cell lines to different extents. Notably, <br/>the pulp extract showed meaningful anti-arthritic properties in rats, evidenced by decreased <br/>inflammation, improved antioxidant status (as shown by decreased plasma malondialdehyde <br/>levels and increased activity of antioxidant enzymes including SOD, catalase, and glutathione <br/>peroxidase), and decreased TNF-α levels. Histopathological examination of joint tissues <br/>confirmed the protective effect of the pulp extract in arthritic rats. |
| 520 #3 - SUMMARY, ETC. |
|---|
| Summary, etc. |
كان الهدف من هذة الدراسة هو تقييم الأنشطة المضادة للأكسدة وللسرطان لمستخلصات أسيتون لب الأفوكادو والقشر والبذور كما تم تقييم التأثير المضاد لإلتهاب المفاصل الروماتويدي لمستخلص الأسيتون من لب الأفوكادو فى نموذج إلتهاب المفاصل الروماتويدي المستحث لفئران التجارب المشابة تماما للذى يحدث فى الإنسان ولتحقيق هذا الهدف تم الأستخلاص لمسحوق لب وقشر وبذور الأفوكادو المجفف بالتجفيد و تم التعرف على المركبات النشطة حيوياً بأستخدام جهاز تحليل الكروماتوجرافى الغازى وتم تقدير المحتوى الكلى للفينولات و الفلافونويد و تم تقييم النشاط المضاد للأكسدة بأستخدام ثلاثة طرق مختلفة و تم دراسة النشاط المضاد للسرطان بإستخدام أنواع مختلفه من الخلايا السرطانية (سرطان الخلايا الكبدية و سرطان الثدى الغدى و سرطان القولون والمستقيم) و تم ايضا تقييم التأثير المضاد لإلتهاب المفاصل الروماتويدي . |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Issues CD |
Issues also as CD. |
| 546 ## - LANGUAGE NOTE |
|---|
| Text Language |
Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Avocado |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
الأفوكادو |
| 653 #1 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Avocado extracts |
| -- |
GC analysis, |
| -- |
Antioxidant |
| -- |
Anti-cancer |
| -- |
Anti-arthritic |
| -- |
مستخلصات الأفوكادو |
| -- |
التحليل الكروماتوجرافى الغازى |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Samir Abdel Moneim Ahmed |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ebtesam Abdel Moneim Mahmoud |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Doha Abdou Mohamed |
| Relator term |
thesis advisor. |
| 900 ## - Thesis Information |
|---|
| Grant date |
01-01-2025 |
| Supervisory body |
Samir Abdel Moneim Ahmed |
| -- |
Ebtesam Abdel Moneim Mahmoud |
| -- |
Doha Abdou Mohamed |
| Universities |
Cairo University |
| Faculties |
Faculty of Agriculture |
| Department |
Department of Agricultural Biochemistry |
| 905 ## - Cataloger and Reviser Names |
|---|
| Cataloger Name |
Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
| Edition |
21 |
| Suppress in OPAC |
No |