Preparation and characterization of tecoma stans nanosystems for photodynamic antimicrobial inactivation / (رقم التسجيلة. 179089)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 08562namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260412133147.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260329s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.544 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.544 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.24.03.Ph.D.2025.As.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Asmaa Youssef Hashem Khattab, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Preparation and characterization of tecoma stans nanosystems for photodynamic antimicrobial inactivation / |
| Statement of responsibility, etc. | by Asmaa Youssef Hashem Khattab ; Supervised Prof. Dr. Maha Fadel Mohamed Ali, Prof. Dr. Nagwa Elsayed Ahmad Awad, Dr. Doaa Ahmed Abdel Fadeel. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير وتوصيف نبات التيكوما في صورة نانوية كمضاد ميكروبي بالعلاج الضوئي الديناميكي |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 141 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 99-141. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Introduction Tecoma stans (T. stans) is a fast-growing plant from the <br/>family Bignoniaceae. Tecoma stans (L.) Jus., a prevalent tree in Egypt, was <br/>reported to be a promising photosensitizer in PDT.Various parts of T. stans <br/>have been used in different biological applications, especially in cancer <br/>treatment and antimicrobial activities. Photodynamic therapy (PDT) is a <br/>promising modality for cancer treatment and antimicrobial activities that <br/>depends on the interaction between a photosensitizer, light, and oxygen. <br/>Tecoma stans yellow flowers crude cold methanolic extract (TSFE) is a <br/>promising anticancer, antimicrobial, and natural photosensitizer for PDT and <br/>this study may inspire further ethnobotanical investigations. <br/>Aim Searching for photosensitizers from plant origin is crucial to <br/>providing nontoxic photosensitizers with high economic antineoplastic and <br/>antimicrobial value. <br/> Method In this study, we investigated the photodynamic activities of <br/>(TSFE) as a natural photosensitizer (PS) source. The phytoconstituents of <br/>TSFE were analyzed by the UPLC/MS/MS technique. This technique <br/>revealed that the extract held compounds that possess cytotoxic and <br/>antimicrobial activities, like luteolin, kaempferol, and isorhamnetin. <br/>Moreover, the photosensitizing agents like coumarins and anthocyanins. The <br/>cytotoxicity of TSFE was examined on the breast carcinoma (MCF-7) and <br/>lung carcinoma (A549) cell lines, in the dark and after irradiation by blue <br/>light (400-450 nm). TSFE contained various phytochemical components with <br/>antineoplastic activity. Moreover, (TSFE) contains coumarins and <br/>anthocyanins that may act as photosensitizers. Furthermore, we investigated <br/>the antimicrobial photodynamic activities of TSFE as a natural <br/>photosensitizer (PS) source against microbes. TSFE was first prepared in a <br/>nanoemulsion form to enhance bioavailability. Antimicrobial photodynamic <br/>therapy (aPDT) is an approach that was recently used to combat the <br/>resistance developed by pathogens toward antimicrobial drugs. This study <br/>investigates the antimicrobial photodynamic activity of the methanolic crude <br/>cold extract of Tecoma stans (L.) Juss. ex Kunth loaded in a nano-emulsion <br/>as a natural photosensitizer. Molecular docking and molecular dynamics <br/>studies were conducted to investigate the binding between delphinidin as a <br/>promising lead and DNA's active site and assessed its stability through <br/>simulation. The nano-emulsion formulation (TSFE-NE) was prepared, <br/><br/><br/>Abstract <br/><br/> <br/><br/>X <br/><br/> <br/><br/>characterized, and evaluated for its antimicrobial photodynamic activities <br/>against three types of microorganisms: Gram-negative bacteria Escherichia <br/>coli (E. coli), Gram-positive bacteria Staphylococcus aureus (S. aureus), and <br/>the pathogenic yeast Candida albicans (C. albicans). <br/> Result )TSFE( showed negligible cytotoxicity against MCF-7 cell lines <br/>at all tested concentrations in the dark. A non-significant cell viability change <br/>was observed upon radiation (P>0.05). TSFE showed significant dark <br/>cytotoxicity on A549 cells, which improved significantly after light radiation <br/>(P<0.05).The percentage of microbial eradication was calculated after <br/>irradiation at 90 Mw/cm2. The microbial eradication of TSFE-NE was <br/>enhanced after light exposure. Eradication percentages of 97.43%, 90.56%, <br/>and 87.77% were obtained for Escherichia coli, Staphylococcus aureus, and <br/>Candida albicans, respectively. These results confirmed the efficacy of <br/>natural photosensitizer and nanotechnology combination for improving <br/>antimicrobial photodynamic activities . |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | تيكوما ستانس، نبات يستخدم على نطاق واسع في الثقافات الشعبية، كعلاج تقليدي آمن وفعال لمختلف الأمراض والمضاعفات. أكدت المصادر التي يمكن الوصول إليها ان الـ تيكوما ستانس أصلها وخصائصها الدوائية العرقية واستخداماتها الطبية العلاجية. إلى جانب مئات المركبات الكيميائية التي تم عزلها، فإن المكونات النشطة الرئيسية هي مركبات الفلافونويد، والقلويدات، والأحماض الفينولية، والأحماض الدهنية. قدمت تيكوما ستانس العديد من الفوائد الطبية، بما في ذلك خصائص مضادة لمرض السكر، ومضادة للالتهابات، ومضادة للسرطان، ومضادة للميكروبات، ومضادة للأكسدة، وواقية للكبد، وواقية للقلب، وواقية للكلى. مستخلص زهرة تيكوما ستانس الخام هو عامل حساس للضوء يمكن أن يعزز أنشطته المضادة للأورام مثل اورام الرئة التي حققت نتائج ملحوظة في تقليل الخلايا السرطانية والمضادة للميكروبات. <br/>تم تحليل المكونات النباتية لـ TSFE بواسطة تقنية.UPLC/MS/MS تم فحص السمية الخلوية<br/>لـ TSFE على خلايا سرطان الثدي (MCF-7) وسرطان الرئة (A549)، في الظلام وبعد التشعيع بالضوء الأزرق (400-450 نانومتر).<br/>يحتوي TSFE على مكونات كيميائية نباتية مختلفة ذات نشاط مضاد للأورام.<br/>علاوة على ذلك، يحتوي TSFE على الكومارين والأنثوسيانين التي قد تعمل كمحسس للضوء.<br/>أظهر TSFE سمية خلوية ضئيلة ضد خطوط الخلايا MCF-7 في جميع التركيزات التي تم اختبارها في الظلام. وقد لوحظ تغير غير هام في قابلية بقاء الخلية عند الإشعاع (P > 0.05). أظهر TSFE سمية خلوية داكنة كبيرة على خلايا A549، والتي تحسنت بشكل ملحوظ بعد الإشعاع الضوئي (P <0.05).<br/>TSFE هو مضاد للسرطان ومحسس ضوئي طبيعي واعد لـ PDT وقد تلهم هذه الدراسة المزيد من التحقيقات العرقية في مضادات السرطان الطبيعية الجديدة الواعدة والمحسسات الضوئية. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Photochemotherapy |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | العلاج الكيميائي الضوئي |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bignoniaceae |
| -- | Tecomastansflower extract |
| -- | natural photosensitizers |
| -- | Phytochemicals |
| -- | Flavonoid |
| -- | alkaloid |
| -- | antioxidants |
| -- | fatty acids |
| -- | Anthocyanins |
| -- | فصيلة البغنونياسيا (فصيلة البرقيات) |
| -- | مستخلص وردة |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Fadel Mohamed Ali |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nagwa Elsayed Ahmad Awad |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doaa Ahmed Abdel Fadeel |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Maha Fadel Mohamed Ali |
| -- | Nagwa Elsayed Ahmad Awad |
| -- | Doaa Ahmed Abdel Fadeel |
| Universities | Cairo University |
| Faculties | National Institute of Laser Enhanced Sciences |
| Department | Department of Medical applications of lasers Speciality laser applications in pharmaceutical sciences |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 29.03.2026 | 93612 | Cai01.24.03.Ph.D.2025.As.P | 01010110093612000 | 29.03.2026 | 29.03.2026 | Thesis |