Pharmacological study of the role of uric acid lowering agents on testosterone-induced benign prostatic hypertrophy via akt/ mtor signaling pathway / (رقم التسجيلة. 179222)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04483namaa22004571i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260416122922.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260405s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.9 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.9 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.09.Ph.D.2025.Ni.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Nibrass Taher Hussein Abdali, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmacological study of the role of uric acid lowering agents on testosterone-induced benign prostatic hypertrophy via akt/ mtor signaling pathway / |
| Statement of responsibility, etc. | by Nibrass Taher Hussein Abdali ; Supervision Prof. Dr. Hala Fahmy Zaki, Prof. Dr. Laila Ahmed Abdelaziz, Dr. Yasmin Shokr Mohamed, Dr. Hassan Afify Hassan. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة دوائية لدور عامل خفض حمض اليوريك على تضخم البروستات الحميد المحدث بالتستوستيرون من خلال مسار أكت/إم تور |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 119 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 96-119. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Benign prostatic hyperplasia is the most common urological condition among elderly men. Because of modifiable metabolic risk factors, the prevalence of benign prostatic hyperplasia is rising. Emerging evidence links elevated uric acid levels to prostatic inflammation and hyperplasia, potentially through oxidative stress and activation of proliferative pathways. Tart-cherry and eugenol were not previously investigated against benign prostatic hyperplasia (BPH).<br/>Eighty healthy male Wistar rats were utilized in the current study and subdivided randomly into ten groups (n=8). BPH was induced by administering testosterone (3 mg/kg; s.c.) for 2 weeks. This was done either alone or after one-week pretreatment with probenecid (200 mg/kg/day; i.p), tart-cherry (500 mg/kg/day; p.o.), eugenol (10 mg/kg/day; p.o.), or a combination of these agents. At the end of the experiment, the prostate tissue was used for biochemical analysis, reverse transcriptase polymerase chain reaction, Western blot analysis, and histological and immunohistochemical assessment<br/>The results revealed a significant increase in prostate index, along with upregulation of cell survival markers like cyclin D1 and characteristic histopathological changes indicative of BPH post-testosterone administration. Additionally, testosterone induced elevated uric acid levels, oxidative stress, inflammatory markers, and activation of pro-survival pathways including PI3-K/AKt/mTOR and NFκB. However, intervention with probenecid, tart-cherry, eugenol adminsterd individually or in combination effectively mitigated these changes, showcasing their anti-inflammatory, antioxidative, and anti-hyperproliferative properties. Notably, the combination therapy demonstrated superior efficacy compared to individual treatments. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | خلصت الدراسة إلى أن إعطاء البروبنيسيد والكرزالمرّ والإيوجينول، سواء بشكل منفرد أو مجتمع، قد أظهر تأثيرًا وقائيًا ضد فرط تنسج البروستات الحميد المحفز بالتستوستيرون في الفئران، مما يوفر نهجًا متعدد الأهداف يشمل مكافحة الالتهاب، تقليل الإجهاد التأكسدي، وكبح مسارات تكاثر الخلايا. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Toxicology |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | علم السموم |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | benign prostatic hyperplasia |
| -- | tart cherry |
| -- | eugenol |
| -- | inflammation |
| -- | probenecid |
| -- | testosterone |
| -- | تضخم البروستات الحميد |
| -- | الكرز الحامض |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy Zaki |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Abdelaziz |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yasmin Shokr Mohamed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hassan Afify Hassan |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Hala Fahmy Zaki |
| -- | Laila Ahmed Abdelaziz |
| -- | Yasmin Shokr Mohamed |
| -- | Hassan Afify Hassan |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmacology & Toxicology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 05.04.2026 | 93670 | Cai01.08.09.Ph.D.2025.Ni.P | 01010110093670000 | 05.04.2026 | 05.04.2026 | Thesis |