Synthesis of some new thiazole derivatives of expected biological activity / (رقم التسجيلة. 179365)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 05033namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260423104238.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260410s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 540 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 540 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.10.M.Sc.2025.Ra.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Rashid Hlail Odhaib Al-Badri, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis of some new thiazole derivatives of expected biological activity / |
| Statement of responsibility, etc. | by Rashid Hlail Odhaib Al-Badri ; Supervisors Prof. Dr. Ahmed Eltaher Mahmoud Mekky, Prof. Dr. Sherif Mohamed Hamed Sanad, Dr. Ahmed Mohamed Abdelfattah Refaie. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشييد بعض مشتقات الثيازول الجديدة ذات النشاط البيولوجي المتوقع |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 108 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 95-108. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Bacterial infections pose a serious threat to public health and <br/>economies. Treating bacterial infections remains a major problem in modern <br/>medicine. Thiazoles and Schiff bases are interesting molecules that <br/>demonstrated intriguing antibacterial applications, especially excellent <br/>antibacterial activity. In this thesis, a wide spectrum of thiazole-based Schiff <br/>bases is prepared as potential antibacterial agents. The targeted products are <br/>prepared via a typical Hantzsch thiazole protocol involved reacting a ternary <br/>mixture of salicylaldehydes, thiosemicarbazide, and the appropriate α-<br/>bromoketones or hydrazonyl chlorides. The reaction was mediated in dioxane <br/>at reflux in the presence of triethylamine. The new products were screened <br/>against different bacteria strains. Schiff bases 8f and 21f demonstrated the <br/>most powerful efficacy against all tested bacteria. They outperformed <br/>ciprofloxacin in its activity against S. aureus and E. faecalis, with MIC/MBC <br/>values of 2.0/4.0 and 1.8/3.7 µM, respectively. Schiff base 8f outperformed <br/>inhibitory activity compared to linezolid with an MIC/MBC of 4.0/16.2 µM <br/>against MRSA ATCC:33591 and ATCC:43300. Schiff base 8f had <br/>comparable activity to linezolid with MIC/MBC of 8.1/32.4 and 4.0/16.2 µM <br/>against VRE ATCC:51299 and VRE ATCC:51575, respectively. <br/>Additionally, Schiff base 21f displayed promising MurB inhibitory activity <br/>with an IC50 of 4.6 µM. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | شكل العدوى البكتيرية تهديدًا خطيرًا للصحة العامة والاقتصاد. ولا يزال علاج هذه العدوى يُمثل مشكلةً رئيسيةً في الطب الحديث. تُعدّ الثيازولات وقواعد شيف جزيئاتٍ مثيرةً للاهتمام أظهرت تطبيقاتٍ مضادةً للبكتيريا مثيرةً للاهتمام، لا سيما نشاطها المضاد للبكتيريا الممتاز. في هذه الأطروحة، يتم تحضير مجموعةٍ واسعةٍ من قواعد شيف القائمة على الثيازول كعوامل مضادةٍ للبكتيريا محتملة.تُحضَّر المنتجات المستهدفة وفقًا لبروتوكول Hantzsch ثيازول النموذجي، ويتضمن تفاعل خليط ثلاثي من ساليسيل ألدهيدات، وثيوسيميكاربازيد، وα-بروموكيتونات أو كلوريدات الهيدرازونيل المناسبة. ويُجرى التفاعل في الديوكسان بوجود ثلاثي إيثيل أمين. وفُحصت المنتجات الجديدة ضد سلالات بكتيرية مختلفة.أظهرت المنتجات الجديدة طيفًا واسعًا من النشاط المثبط ضد البكتيريا المختبرة. أظهر بعضها نشاطًا ملحوظًا ضد S. aureus وE. faecalis، بقيم MIC/MBC تصل إلى 2.0/4.0 ميكرومولار. كما أظهر بعضها نشاطًا ملحوظًا ضدMRSA و VRE بقيم MIC/MBC تصل الى 4.0/16.2 ميكرومولار. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Chemistry |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | كيمياء |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hantzsch thiazole synthesis |
| -- | Schiff bases |
| -- | MRSA inhibitors |
| -- | VRE inhibitors |
| -- | Thiazoles |
| -- | تفاعل Hantzschلتشييد الثيازول |
| -- | ؛ قواعد شيف |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Eltaher Mahmoud Mekky |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherif Mohamed Hamed Sanad |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Mohamed Abdelfattah Refaie |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Ahmed Eltaher Mahmoud Mekky |
| -- | Sherif Mohamed Hamed Sanad |
| -- | Ahmed Mohamed Abdelfattah Refaie |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Eman Ghareb |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 10.04.2026 | 93723 | Cai01.12.10.M.Sc.2025.Ra.S | 01010110093723000 | 10.04.2026 | 10.04.2026 | Thesis |