Kynurenine pathway as a possible pharmacological target in interferon-induced depression in rats / (رقم التسجيلة. 179536)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03479namaa22003971i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260416183304.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260416s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.32 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.32 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.09.M.Sc.2025.Mo.K |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mohanad Zaki Abdelsalam Zaki, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Kynurenine pathway as a possible pharmacological target in interferon-induced depression in rats / |
| Statement of responsibility, etc. | by Mohanad Zaki Abdelsalam Zaki ; Supervision Dr. Nesrine Salah Eldin El-Sayed, Dr. Gouda Kamel Helal, Dr. Reham Mohamed Essam. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | المسار الكينوريني كهدف دوائي محتمل في الاكتئاب المستحث بالإنترفيرون في الجرذان |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 134 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 99-133. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Depression is a highly prevalent and disabling disorder that is <br/>frequently linked to neuroinflammation and dysregulation of the kynurenine <br/>pathway, a major branch of tryptophan metabolism. The present study <br/>investigated the potential therapeutic effects of epigallocatechin gallate <br/>(EGCG), a polyphenolic constituent of green tea, on depressive-like behaviors <br/>and kynurenine pathway modulation in a rat model of interferon (IFN)-<br/>induced depression. Rats received IFN at a dose of 6 × 10⁴ IU/kg/day, <br/>subcutaneously (s.c.), while EGCG was administered at 20 mg/kg/day for <br/>seven consecutive days. Behavioral testing, biochemical measurements, and <br/>histopathological analyses were performed to assess the impact of EGCG on <br/>depressive-like behavior, tryptophan and serotonin metabolism, kynurenine <br/>pathway intermediates, oxidative stress parameters, neuroinflammatory <br/>cytokines, and glial activation. The results demonstrated that EGCG <br/>significantly improved depression-like behaviors, normalized serotonin <br/>levels, and decreased neurotoxic kynurenine derivatives, including quinolinic <br/>acid. In addition, EGCG attenuated oxidative stress, as indicated by lower <br/>malondialdehyde levels, reduced pro-inflammatory cytokines such as TNF-α, <br/>enhanced antioxidant defenses including glutathione, and upregulated anti-<br/>inflammatory cytokines such as IL-4. Histological evaluation further revealed <br/>that EGCG preserved hippocampal neuronal architecture and reduced glial <br/>activation, as reflected by diminished glial fibrillary acidic protein expression. <br/>Collectively, these findings suggest that EGCG exerts antidepressant-like <br/>effects by regulating the kynurenine pathway, mitigating neuroinflammation, <br/>and protecting neuronal integrity, underscoring its potential as a therapeutic <br/>agent in depression management. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmacology and Toxicology |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Depression |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nesrine Salah Eldin El-Sayed |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Nesrine Salah Eldin El-Sayed |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmacology and Toxicology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 16.04.2026 | 93789 | Cai01.08.09.M.Sc.2025.Mo.K | 01010110093789000 | 16.04.2026 | 16.04.2026 | Thesis |