A comparative study between the use of topical betamethasone cream or topical olive oil cream as prophylactic agents in reducing acute radiodermatitis in breast cancer patients / (رقم التسجيلة. 179626)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 08721namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260420203326.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260420s2025 ua |a||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.99449 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.99449 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.08.Ph.D.2025.Is.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Israa Kamal Mohamed, |
| Preparation | preparation. |
| 245 12 - TITLE STATEMENT | |
| Title | A comparative study between the use of topical betamethasone cream or topical olive oil cream as prophylactic agents in reducing acute radiodermatitis in breast cancer patients / |
| Statement of responsibility, etc. | by Israa Kamal Mohamed ; Supervision Prof. Dr. Samar F. Farid, Prof. Dr. Maggie M. Abbassi, Prof. Dr. Mohamed R. Kelany. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة مقارنة بين استخدام كريم بيتاميثازون الموضعي أو كريم زيت الزيتون الموضعي كعوامل وقائية في الحد من التهاب الجلد الإشعاعي الحاد لدى مرضى سرطان الثدي |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 138 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 92-111. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | Purpose: Breast cancer is the most common malignancy among Egyptian women and <br/>represents a major public health concern. Recent estimates indicate that breast cancer accounts for <br/>approximately 32–39% of all female cancers in Egypt. Radiotherapy is a cornerstone of breast <br/>cancer management as it is commonly used after both breast-conserving surgery and mastectomy, <br/>depending on tumor characteristics and patient risk factors. Skin is the first organ exposed to <br/>radiation, leading to the most common side effect, acute radiation-induced dermatitis (RID), which <br/>is a complex process involving direct cellular damage, oxidative stress, and multiple inflammatory <br/>responses. This study aims to compare topical betamethasone-17-valerate and olive oil cream in <br/>preventing (RID) in breast cancer patients, to provide prospective data evaluating the quality of <br/>life, subjective symptoms, and treatment satisfaction reported by the patients, and to translate and <br/>validate the Functional Assessment of Chronic Illness Therapy – General Treatment Satisfaction <br/>(FACIT-TS-G) questionnaire into Arabic for use in the study population. <br/><br/> Methods: This was a prospective, double-blind, randomized, parallel, placebo-controlled <br/>trial. A total of 132 patients were randomized into three groups to receive either olive oil cream <br/>(G1), betamethasone-17-valerate (Betnovate® cream, GlaxoSmithKline) (G2), or unmedicated <br/>cream base (G3) throughout radiotherapy (RT) and 2 weeks after. The study is registered on <br/>clinicaltrials.gov with ID: NCT05285943, Date: November 2021. <br/><br/>Results: A total of 128 patients were included in the final analysis. Regarding the <br/>proportions of patients developing different Radiation Therapy Oncology Group (RTOG) grades, <br/>betamethasone and olive oil significantly differed from the unmedicated cream base at weeks 1 – <br/>4 (P <0.05). At week 5, only significance was observed between olive oil and unmedicated cream <br/>base (P =0.013), and the mean RTOG grades was significantly lower in olive oil and betamethasone <br/>groups than in the unmedicated cream base group (P < 0.05 at weeks 1 – 5) but, there was no <br/>significant difference between olive oil and betamethasone (P>0.999). Furthermore, the percentage <br/>of patients who developed grade 3 at the end of the follow-up was significantly different between <br/>the olive oil group and the unmedicated cream base group (27.9 % vs 61%, p = 0.004). <br/>Additionally, olive oil and betamethasone had non-significant delayed grade 2 and grade 3 <br/>development (P >0.999). Differences in Dermatology Life Quality Index (DLQI) scores or <br/>summed Visual Analog Scale (VAS) between the olive oil and unmedicated cream base groups, as <br/>well as the betamethasone and unmedicated cream base groups, were statistically significant (P< <br/>0.001). However, the difference between the olive oil and betamethasone groups was not <br/>statistically significant (P> 0.999). There was a non-significant time and group interaction for both <br/>the DLQI scores (p = 0.848) and the summed VAS scores (p = 0.11), indicating that the changes <br/>in these outcomes over time were consistent across different times and an overall reduction in the <br/>patients' DLQI score and summed VAS score mean, regardless of the topical treatment received. <br/><br/>Conclusion: Although neither intervention demonstrated prophylactic efficacy, olive oil <br/>cream is as effective as betamethasone in mitigating radiodermatitis severity, delaying the onset of <br/>radiodermatitis, reducing the incidence of grade 3 dermatitis, and preventing treatment <br/>interruptions compared to unmedicated base cream in patients treated with adjuvant radiotherapy <br/>for breast cancer. FACIT-TS-G version 4 is now validated in Arabic and approved by FACIT and <br/>can be used in clinical trials with permission (www.facit.org). |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | الهدف: الغرض من هذه الدراسة هو مقارنة كريم بيتاميثازون-17-فاليريت الموضعي وزيت الزيتون في الوقاية من التهاب الجلد الناجم عن الإشعاع (RID) لدى مريضات سرطان الثدي وتوفير بيانات مستقبلية لتقييم نوعية الحياة والأعراض الذاتية ورضا العلاج الذي أبلغ عنه المرضى. المرضى و الطرق المستخدمة: كانت هذه دراسة مستقبلية، مزدوجة التعمية، عشوائية، موازية، مضبوطة بعلاج وهمي. تم تززيع 132 مريضة عشوائيًا إلى ثلاث مجموعات لتلقي إما كريم زيت الزيتون (G1)، أو بيتاميثازون-17-فاليريت (كريم بيتنوفيت®، جلاكسو سميث كلاين) (G2)، أو قاعدة كريم غير معالج (G3) طوال فترة العلاج الإشعاعي (RT) وبعده بأسبوعين. سُجِّلت الدراسة على موقع clinicaltrials.gov برقم تعريف: NCT05285943، بتاريخ: نوفمبر 2021. النتائج: تم تضمين 128 مريضة في التحليل النهائي. اختلف بيتاميثازون وزيت الزيتون اختلافًا كبيرًا عن قاعدة كريم غير معالج في الأسابيع 1-4 (P<0.05). في الأسبوع 5، لوحظ وجود دلالة إحصائية فقط بين زيت الزيتون وقاعدة كريم غير معالج (P = 0.013)، وكان متوسط درجةRTOG (مجموعة العلاج الإشعاعي لسرطان للأورام) أقل بكثير في مجموعتي زيت الزيتون وبيتاميثازون مقارنةً بالمجموعة الأخرى (P<0.05 في الأسابيع 1-5)، ولكن لم يكن هناك فرق كبير بين زيت الزيتون وبيتاميثازون (P> 0.999). علاوة على ذلك، كانت نسبة المرضى الذين أصيبوا بالدرجة الثالثة في نهاية المتابعة مختلفة بشكل كبير بين مجموعة زيت الزيتون وقاعدة كريم غير معالج (27.9% مقابل 61%، P = 0.004). بالإضافة إلى ذلك، أظهر زيت الزيتون وبيتاميثازون تأخيرًا غير ذي دلالة إحصائية في تطور الدرجتين الثانية والثالثة (P > 0.999). الاستنتاج: كريم زيت الزيتون بنفس فعالية بيتاميثازون في تخفيف أعراض الـ RID لدى المريضات اللاتي خضعن للعلاج الإشعاعي المساعد لسرطان الثدي. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Breast Cancer |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | سرطان الثدي |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancer |
| -- | Radiotherapy |
| -- | Acute radiation-induced dermatitis |
| -- | Betamethasone |
| -- | Olive oil |
| -- | Patient-reported outcomes |
| -- | سرطان الثدي |
| -- | العلاج الإشعاعي |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samar F. Farid |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maggie M. Abbassi |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed R. Kelany |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Samar F. Farid |
| -- | Maggie M. Abbassi |
| -- | Mohamed R. Kelany |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Clinical Pharmacy |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 20.04.2026 | 93841 | Cai01.08.08.Ph.D.2025.Is.C | 01010110093841000 | 20.04.2026 | 20.04.2026 | Thesis |