Design, synthesis and evaluation of novel pyrazoline derivatives as anticancer agents / (رقم التسجيلة. 179739)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04719namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GICUC |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20260426141318.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260426s2025 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.19 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.8.04.M.Sc.2025.Mi.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Michael Medhat Sawiris, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and evaluation of novel pyrazoline derivatives as anticancer agents / |
| Statement of responsibility, etc. | by Michael Medhat Sawiris ; Supervision Prof. Dr. Omneya Mahmoud Khalil, Prof. Dr. Peter Amir Halim, Prof. Dr. Marwa Sobhy Ahmed. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتشييد وتقييم مشتقات بيرازولين جديدة كمضادات للسرطان |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 162 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2025. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 158-160. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | This thesis is composed of three chapters in addition to a summary and conclusion in English and in Arabic. The first chapter serves as a general introduction that gives a brief about the relationship between RTKs and cancer progression and highlights the potential of pyrazole derivatives as effective RTK inhibitors. The second chapter is a review article titled: “From Lab to Target: Pyrazole, Pyrazoline and Fused Pyrazole Derivatives as Receptor Tyrosine Kinase Inhibitors in Cancer Therapy” that reviews recent studies on pyrazole derivatives and related compounds that inhibit several RTKs, outlining their biological activities, structure–activity relationships and synthetic approaches. The third chapter, a research article titled: “Design, synthesis and biological evaluation of novel pyrazoline derivatives as dual EGFR/VEGFR-2 inhibitors for targeted cancer therapy” is an experimental chapter that describes the design and synthesis of novel pyrazoline derivatives aimed at simultaneously blocking EGFR and VEGFR2 kinases. |
| 520 #3 - SUMMARY, ETC. | |
| Summary, etc. | تتكوّن هذه الرسالة من ثلاثة فصول، بالإضافة إلى ملخص وخاتمة باللغتين الإنجليزية والعربية. يعرض الفصل الأول مقدمة عامة تتناول بإيجاز العلاقة بين مستقبلات التيروزين كيناز (RTKs) وتطور السرطان، كما يسلّط الضوء على التأثير الواعد لمشتقات البيرازول كمثبطات فعالة لهذه المستقبلات. أما الفصل الثاني، فهو مقال مرجعي بعنوان: "من المختبر إلى الهدف: البيرازول، البيرازولين ومشتقات البيرازول المدمجة كمثبطات لمستقبلات التيروزين كيناز في علاج السرطان"، ويتناول هذا الفصل الدراسات الحديثة حول مشتقات البيرازول والمركبات ذات الصلة المثبطة لعدة مستقبلات تيروزين كيناز، مع عرض لأنشطتها البيولوجية. بالإضافة إلى دراسة العلاقة بين تركيب المركبات ومدى فاعليتها والأساليب المستخدمة في تشييدها. بينما يُعد الفصل الثالث، وهو مقال بحثي بعنوان: "تصميم، تشييد وتقييم النشاط البيولوجي لمشتقات بيرازولين جديدة كمثبطات مزدوجة لـ EGFR وVEGFR-2 لاستهداف علاج السرطان"، فصلاً عملياً يصف تصميم تشييد مشتقات بيرازولين جديدة تهدف إلى التثبيط المتزامن لكلٍّ من مستقبل عامل نمو البشرة (EGFR) ومستقبل عامل نمو بطانة الاوعية الدموية-2 (VEGFR2). |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drugs |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | العقاقير |
| 653 #1 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anticancer |
| -- | Pyrazoline |
| -- | Receptor tyrosine kinase |
| -- | EGFR |
| -- | VEGFR2 |
| -- | Dual inhibitor |
| -- | مضاد للسرطان |
| -- | بيرازولين |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omneya Mahmoud Khalil |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Peter Amir Halim |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Sobhy Ahmed |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2025 |
| Supervisory body | Omneya Mahmoud Khalil |
| -- | Peter Amir Halim |
| -- | Marwa Sobhy Ahmed |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmaceutical Organic Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 26.04.2026 | 93874 | Cai01.8.04.M.Sc.2025.Mi.D | 01010110093874000 | 26.04.2026 | 26.04.2026 | Thesis |