Design, synthesis and biological evaluation of novel 2 - oxopyridine and 2- iminopyridine derivatives as potential anticancer and phosphodiesterase inhibitors / (Record no. 24671)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01922nam a2200301 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223025954.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 091201s2009 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Gift |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.34.M.Sc.2009.Mo.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Assem Omar Abdelfattah |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and biological evaluation of novel 2 - oxopyridine and 2- iminopyridine derivatives as potential anticancer and phosphodiesterase inhibitors / |
| Statement of responsibility, etc. | Mohamed Assem Omar Abdelfattah ; Supervised Ashraf H. Abadi , Dalal A. Abouelella |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتشييد وتقييم بيولوجى لبعض مشتقات الاكسوبيريدين والامينوبيريدين كمضادات للسرطان ومثبطات لانزيم فوسفودايستراز |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Assem Omar Abdelfattah , |
| Date of publication, distribution, etc. | 2009 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 119 Leaves : |
| Other physical details | charts ; |
| Dimensions | 30cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Milrinone is a cyanopyridone derivative that has been introduced for the treatment of CHF . Its mechanism of action involves inhibition of PDE3, leading to elevation of cAMP increasing the entry of Ca++ ions into the cardiac tissues and hence increasing the contractility of the cardiac muscle . On the other hand recent studies showed that PDE3 and other PDEs are over - expressed in malignant tumors and the inhibition of such PDEs and consequent high levels of cAMP or cGMP or both may be associated with anticancer and apoptotic activities |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ashraf H. Abadi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalal Abdelrahman Abouelella , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 902 ## - LOCAL DATA ELEMENT B, LDB (RLIN) | |
| No. of Items | 2 |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Fatma |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Copy number | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الثقاقات الاجنبية - الدور الثالث | 11.02.2024 | Cai01.34.M.Sc.2009.Mo.D | 01010110060233000 | 05.07.2024 | C.2 | Thesis | |
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الثقاقات الاجنبية - الدور الثالث | 11.02.2024 | Cai01.34.M.Sc.2009.Mo.D | 01010110052215000 | 05.07.2024 | Thesis |