Study on the effect of cilostazol on experimentally induced renal failure in rats / (Record no. 49645)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02553cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031149.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150302s2014 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2014.Di.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Diaa Eldeen Ragab Mahmoud Sakr |
| 245 10 - TITLE STATEMENT | |
| Title | Study on the effect of cilostazol on experimentally induced renal failure in rats / |
| Statement of responsibility, etc. | Diaa Eldeen Ragab Mahmoud Sakr ; Supervised Hanan Elabhar , Dalaal Abdallah |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دارسة تجريبية حول تأثير السيلوستازول على الفشل الكلوى المحدث تجريبيا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Diaa Eldeen Ragab Mahmoud Sakr , |
| Date of publication, distribution, etc. | 2014 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 162 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cilostazol, a phosphodiesterase- III inhibitor, reportedly exhibits positive effects against Ischemia / reperfusion (I / R) induced injury in several models. However, its potential role against the renal I / R insult has not been elucidated. To test whether the PPAR- Þ (of peroxisome proliferator activated receptor gamma) pathway is involved in the cilostazol effect, rats were randomized into sham, I / R, cilostazol (50 and 100 mg / kg per day, orally), pioglitazone (3 and 10 mg / kg per day, orally) and their combination at the low dose levels. Drugs regimens were administered for 14 days prior to the I/R induction. Pretreatment with cilostazol or pioglitazone provided significant protection against the I/R-induced renal injury as manifested by the attenuated serum levels of creatinine, blood urea nitrogen and cystatin C. Both drugs have also opposed the I/R-induced elevation in tissue contents/activity of neutrophil gelatinase - associated lipocalin (NGAL), kidney injury molecule -1 (Kim -1), nuclear factor- кB, interleukin -18, caspase -1, as well as malondialdehyde, iNOS, myeloperoxidase, ICAM 1 and VCAM 1. Nevertheless, the drugs increased both the PPAR- Þ activity and the content of glutathione |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cilostazol |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ischemia reperfusion |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Poiglitazone |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalaal Moustafa Abdallah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Sala Eldeen Elabhar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2014.Di.S | 01010110064705000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2014.Di.S | 01020110064705000 | 22.09.2023 | CD - Rom | 64705.CD |