Evaluation of the role of keratinocytes apoptosis and impaired cell to cell adhesion in vitiligo: Immunohistochemical expression of MART1, P53 and E-cadherin / (Record no. 53842)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02726cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031351.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151209s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.27.Ph.D.2015.Mo.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Hussien Mostafa Elmahdy |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of the role of keratinocytes apoptosis and impaired cell to cell adhesion in vitiligo: Immunohistochemical expression of MART1, P53 and E-cadherin / |
| Statement of responsibility, etc. | Mohammed Hussien Mostafa Elmahdy ; Supervised Naiema A.M. Marie , Samia Mohammed Gabal , Mostafa Samy Salem |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | (E-cadherin) و (P53)(MART) تقييم دور موت الخلايا الكيراتينية المبرمج و اضطراب اتصال الخلايا ببعضها في البهاق: التعبير المناعي لكل من |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohammed Hussien Mostafa Elmahdy , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 125 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Vitiligo is an acquired, hypomelanotic skin disorder characterized by circumscribed depigmented macules. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes. Some studies supported the hypothesis that keratinocytes apoptosis and impaired intercellular adhesion may play a role in the pathogenesis of vitiligo. Objectives: To assess the role of keratinocytes apoptosis and impaired intercellular adhesion in the pathogenesis of vitiligo through the studying of immunohistochemical presence and distribution of MART1, P53 and E-cadherin in the epidermis Results: Regarding to immunostaining of both E-cadherin & P53, there was a highly significant difference between lesional biopsies of cases and control groups. Also there was a highly significant difference between lesional biopsies of cases and perilesional and non lesional biopsies of the same cases. No significant difference was noted regarding the disease stability. Conclusion: vitiligo is not a disease confined to melanocytes. Keratinocytes apoptosis and impaired cell to cell adhesion may play prominent role in the pathogenesis of the disease. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Apoptosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cell adhesion |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vitiligo |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mostafa Samy Salem , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naiema Abdelmonaem Marie , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samia Mohammed Gabal , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.27.Ph.D.2015.Mo.E | 01010110067087000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.27.Ph.D.2015.Mo.E | 01020110067087000 | 22.09.2023 | CD - Rom | 67087.CD |