immunohistochemical study of ALDH1A1 expression in different colonic lesions / (رقم التسجيلة. 55764)
[ عرض عادي ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03250cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031448.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160328s2015 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.27.M.Sc.2015.Sa.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sara Mohamad Aboufandoud Mohamad |
| 245 10 - TITLE STATEMENT | |
| Title | immunohistochemical study of ALDH1A1 expression in different colonic lesions / |
| Statement of responsibility, etc. | Sara Mohamad Abou Fandoud Mohamad ; Supervised Fahima Mohamad Habib , Hala Naguib Hosni , Amira Mohamad Bassam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة مناعية نسيجية كيميائية لتعبير ايه ال دى اتش ١أ١ فى أدواء القولون المختلفة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sara Mohamad Aboufandoud Mohamad , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 197 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Increasing evidence has proposed that tumor contains tumor initiating cells or cancer stem cells (CSCs) that are responsible for its progression and relapse. Aldehyde dehydrogenase 1A1 (ALDH1A1) has recently been identified as a marker for cancer stem cells in some human malignancies including colorectal cancer (CRC). Aim of Work: The assessment of immunohistochemical (IHC) expression of ALDH1A1 in different colonic lesions, tracking human colonic stem cells during CRC development and its correlation with the clinicopathological features of such lesions. Methods: This study consisted of 45 cases of colonic tissue sections, selected as 5 cases of normal colonic tissue & 10 cases for each of chronic non specific colitis, inflammatory bowel disease, colonic adenoma & CRC. IHC reactions were carried out by using ALDH1A1 monoclonal antibody. A total score of ALDH1A1 expression is obtained by multiplying the score of staining intensity and score of percentage of positively stained cells to obtain score ranging from 0 up to 12. Results: IHC staining of ALDH1A1 in the selected cases displayed a heterogeneous expression pattern, with differences in the distribution and intensity of pos»itivity. According to ALDH1A1 score, 22 cases (48.9%) were negative, 19 cases (42.2%) were weakly positive, 2 cases (4.4%) were moderately positive & 2 cases (4.4%) were strongly positive. There was no statistical significant correlation detected regarding ALDH1A1 score with age & sex for all the selected cases except in normal colonic tissue cases, a significant correlation was detected regarding ALDH1A1 score with sex (P value = 0.025). Also, there was no statistical significant correlation detected regarding ALDH1A1 score with dysplasia in colonic adenoma cases or with tumor type, site, shape, size, grade & TNM staging in CRC cases (P value > 0.05) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ALDH1A1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cancer stem cellscolorectal cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Normal colon |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amira Mohamad Bassam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fahima Mohamad Habib , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Naguib Hosni , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Aml |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.27.M.Sc.2015.Sa.I | 01010110068428000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.27.M.Sc.2015.Sa.I | 01020110068428000 | 22.09.2023 | CD - Rom | 68428.CD |