Histopathologic study and immunohistochemical expression of WT1 protein in different types and grades of astrocytic tumors / (Record no. 56015)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03253cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031455.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160414s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.27.Ph.D.2015.Na.H |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nashwah Samir M. Abdalmoneim Alhariry |
| 245 10 - TITLE STATEMENT | |
| Title | Histopathologic study and immunohistochemical expression of WT1 protein in different types and grades of astrocytic tumors / |
| Statement of responsibility, etc. | Nashwah Samir M. Abdalmoneim Alhariry ; Supervised Badawia Bayoumy Ibrahim , Mustafa M. Sami Salem , Amal Ahmad M. Hareedy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسه هستوباثولوجيه والتعبيرالهستوكيميائى المناعى للبروتين دبليوتى1 في مختلف أنواع ودرجات الاورام النجميه |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nashwah Samir M. Abdalmoneim Alhariry , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 116 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background:Wilms{u2019} tumour gene product (WT1) is an embryonic zinc-finger transcription factor, which was originally identified as a tumor suppressor gene and documented as a target for gene therapy of many solid tumors including astrocytic tumors. Aim of work: The aim of this study is the assessment of immunohistochemical expression of WT1 protein, in different histologic types and grades of astrocytic tumors. WT1 protein expression will be correlated with various clinical data (such as age, sex).Material and Methods: The material of this study consisted of 80 paraffin blocks of astrocytoma cases collected from Nasser Institute for Research and Treatment from January 2012 toDecember 2013.Results: WT1 was expressed in (25/28) grade I astrocytomas, all grade II astrocytomas (14/14), (13/16) grade III astrocytomas and (21/22) grade IV with highly significant relationship (P-value<0.001) between grade I and grade IV, grade III and grade IV. Expression was the highest in older ages (significantp-value = 0.034),in male cases (insignificantp-value = 0.298) and in areas of perivascular proliferation and the astrocytic tumors subtypes (gemistocytic astrocytoma, pleomorphic xanthoastrocytoma, protoplasmic astrocytoma and glioblastoma). Conclusion:Many factors affect the expression of WT1 in astrocytomas, rather than the tumor grade, which include tumor vasculature, patient age and the tumor subtype. Recommendations:Further studies are recommended for assessment of WT1 expression in astrocytomas in relation to other brain tumors for detection of its specificity and sensitivity for astrocytic tumors and correlation of WT1 expression with the extent of tumor vasculature and each of astrocytoma histologic subtype and patients{u2019} age. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Astrocytic tumors |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Astrocytoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | WT1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amal Ahmad M. Hareedy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | BadawiaBayoumy Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mustafa M. Sami Salem , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Aml |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.27.Ph.D.2015.Na.H | 01010110068633000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.27.Ph.D.2015.Na.H | 01020110068633000 | 22.09.2023 | CD - Rom | 68633.CD |