Determination of serum human aldehyde dehydrogenase (ALDH) concentration in hepatitis C virus (HCV) infected Egyptian patients with liver cirrhosis and hepatocellular carcinoma / (Record no. 56574)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03239cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031512.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160521s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.06.M.Sc.2015.En.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Enas Mohamed Elhusseiny Ahmed |
| 245 10 - TITLE STATEMENT | |
| Title | Determination of serum human aldehyde dehydrogenase (ALDH) concentration in hepatitis C virus (HCV) infected Egyptian patients with liver cirrhosis and hepatocellular carcinoma / |
| Statement of responsibility, etc. | Enas Mohamed Elhusseiny Ahmed ; Supervised Abdelgwad Hashem , Aymen Samir Yassin , Amal Ahmed Mohammed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | ٍفى المرضى المصريين الذين يعانون من عدوى فيروس سى الإلتهاب الكبدى الوبائى مع تليف و سرطان الكبد (ALDH) الكشف عن تركيزإنزيم ال |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Enas Mohamed Elhusseiny Ahmed , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 119 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatocellular carcinoma is a primary malignancy of the liver. Hepatocellular carcinoma is now the third leading cause of cancer deaths worldwide, with over 500,000 people affected. In Egypt, hepatocellular carcinoma (HCC) is the second most common cancer in men and the 6th most common cancers in women. This rising incidence and its' poor prognosis make the early detection and surveillance of hepatocellular carcinoma of high importance. Aldehyde dehydrogenase (ALDH) is a polymorphic enzyme responsible for the oxidation of aldehydes to carboxylic acids, which leave the liver and are metabolized by the body{u2019}s muscle and heart. ALDH1 and ALDH2 are the most important enzymes for aldehyde oxidation. These enzymes are found in many tissues of the body but are at the highest concentration in the liver. The aim of this study is to evaluate the diagnostic value of serum Aldehyde dehydrogenase level in hepatitis C virus infected Egyptian patients with cirrhosis and hepatocellular carcinoma. This study included 50 patients with cirrhosis, 50 patients with hepatocellular carcinoma and 37 healthy volunteers. For all groups we studied clinical data, liver function tests, viral markers, serum alpha fetoprotein (AFP) and ALDH concentration using enzyme linked immunosorbent assay (ELISA). Our data showed that ALDH was more sensitive and specific than AFP, ALDH had 74% sensitivity and 82% specificity, P- value (0.000) but AFP had 66% sensitivity and 64% specificity, P - value (0.003). ALDH could be used as useful diagnostic marker for detection of hepatocellular carcinoma and in differentiation between HCC and cirrhosis at a cut off value of 41 U / L |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Aldehyde dehydrogenase enzyme |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatitis C virus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular carcinoma |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelgwad Hashem , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amal Ahmed Mohammed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aymen Samir Yassin , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.06.M.Sc.2015.En.D | 01010110068960000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.06.M.Sc.2015.En.D | 01020110068960000 | 22.09.2023 | CD - Rom | 68960.CD |