Design and testing of a novel peptide vaccine against the mucosal pathogen moraxella catarrhalis with emphasis on protecting chronic obstructive pulmonary disease patients from exacerbations / (Record no. 56982)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02879cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031524.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160620s2016 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.06.M.Sc.2016.Ge.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gehad Mohsen Yassin |
| 245 10 - TITLE STATEMENT | |
| Title | Design and testing of a novel peptide vaccine against the mucosal pathogen moraxella catarrhalis with emphasis on protecting chronic obstructive pulmonary disease patients from exacerbations / |
| Statement of responsibility, etc. | Gehad Mohsen Yassin ; Supervised Magdy Ali Amin , Ahmed Sherif Attia |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم و اختبار لقاح بيبتيدى جديد ضد الممراض المخاطى المسمى بالموركسيلة النزلية لحماية مرضى الداء الرئوى المسد المزمن من نشاط المرض |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Gehad Mohsen Yassin , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 132 Leaves ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Moraxella catarrhalis is an established pathogen that is causing substantial infections to both children and adults. However, so far there is not effective vaccine that could halt the spread of these infections. Immunoinformatics tools were used to predict M. catarrhalis epitopes that would be capable of offering immunoprotection among major proportions of human populations worldwide. Mice were immunized with best three peptides then challenged with M. catarrhalis in the pulmonary clearance model. Finally, antibodies against these epitopes were detected in humans. Immunoinformatics analyses identified 44 epitopes which are predicted to be good MHC II binders and at the same time show high population coverages worldwide. Upon intraprotenial mice immunization with the best three peptides, peptide 2A3 derived from the lactoferrin binding protein A showed superior activity in immunogenicity and in clearing M. catarrhalis from mice lungs. Higher clearance was obtained upon combining intraprotenial with intranasal immunization. Upon examining the sera from otitis media children infected with M. catarrhalis, antibodies levels against peptide 2A3 were significantly higher than those detected in non otitis media ones. Peptide 2A3 is the first promising peptide based vaccine against M. catarrhalis. Immunoinformatics predicts it should have a global protection around the world. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Exacerbations |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mucosal pathogen moraxella |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Novel peptide vaccine against |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Sherif Attia , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Ali Amin , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.06.M.Sc.2016.Ge.D | 01010110069350000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.06.M.Sc.2016.Ge.D | 01020110069350000 | 22.09.2023 | CD - Rom | 69350.CD |