A Pharmaceutical study on taste masking of a certain bitter drug / (Record no. 57130)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02666cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031528.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170118s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2016.So.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Soha Sayed Abulella Ahmed |
| 245 12 - TITLE STATEMENT | |
| Title | A Pharmaceutical study on taste masking of a certain bitter drug / |
| Statement of responsibility, etc. | Soha Sayed Abulella Ahmed ; Supervised Mohamed F. Elmiligi , Magdy Ibrahim Mohamed , Howida Kamal Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة صيدلية لتحسين مذاق احد العقاقير المرة المذاق |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Soha Sayed Abulella Ahmed , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 210 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study aimed to mask the bitter taste of Mebeverine HCl by using different methods including; ion exchange resin complexation technique and formation of solid dispersion. Evaluation studies were followed the formulation to evaluate the ability of formulae in masking the bitter taste of the drug. Hence, the work in this thesis was divided into two chapters. First one is formulation of Mebeverine HCl resinates using Tulsion 660 which is a cation exchange resin and then formulation of Mebeverine HCl solid dispersions using four different carriers in the second chapter. Drug resinate was evaluated for taste masking by using panel and UV methods, equilibrium time, drug loading and in-vitro drug release. Study of drug release from its resinates was obtained at salivary pH (phosphate buffer of pH 6.8) and gastric pH (0.1 N HCl of pH 1.2) for 2 hours. The formula DR18 which contained drug: resin ratio of 1:4, drug amount of 1% and formulated by double loading technique was selected as the formula of choice in case of ion exchange resin Complexation concerning the last mentioned evaluation tests in masking drug bitter taste. The selected solid dispersion formula (SD7) which contained drug: Eudragit E100 ratio of 1:5 and prepared by using rotovap solvent evaporation technique had no bitter taste showing high score concerning panel test |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bitter drugs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mebeverine hydrochloride |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Taste masking |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Howida Kamal Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Ibrahim Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Fareed Elmiligi , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2016.So.P | 01010110069454000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2016.So.P | 01020110069454000 | 22.09.2023 | CD - Rom | 69454.CD |