Enhancement of solubility and bioavailability of glimepiride using nanotechnology / (Record no. 57770)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02736cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031547.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170119s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2016.Mu.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mugahed Mohammed Ahmed Algamrah |
| 245 10 - TITLE STATEMENT | |
| Title | Enhancement of solubility and bioavailability of glimepiride using nanotechnology / |
| Statement of responsibility, etc. | Mugahed Mohammed Ahmed Algamrah ; Supervised Ahmed Abdelbary Abderahman , Omneya Mohamed Abdelkader |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحسين الأذابة والأتاحة الحيوية لعقار الجليمبيرايد بأستخدام تكنولوجيا النانو |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mugahed Mohammed Ahmed Algamrah , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 166 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Many of Poorly aqueous soluble drugs including antihypertensive agents, antidiabetic agents and anti cancer agents require novel delivery technologies that will enhance their GIT absorption, maximize their bioavailability and lead to efficient therapeutic effect. Over the past two decades, there has been a steady rise in the number of commercially available nanoparticle (NP), solid nanodispersion and solid lipid nanoparticles (SLNs) therapeutics as novel delivery technologies intended to enhance the GIT absorption, maximize the bioavailability and lead to efficient therapeutic effect of poorly aqueous soluble drugs. Glimepiride is considered as new generation of sulfonyl urea and administered orally. Its main draw back is its poor solubility. Glimepiride, chemically described as 1-[[4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1- carboxamide) ethyl] phenyl] sulphonyl] -3-(trans-4-methylcyclohexyil) urea, is water insoluble oral antidiabetic drug from the sulfonylurea class, which is widely used in the treatment of type 2 diabetes. Glimepiride was selected as drug candidate, as it is not available in such dosage forms and thus, to enhance safety and efficacy of Glimepiride, achieve better compliance, solve the problem of solubility, absorption and bioavailability. To achieve these goals, the work in our thesis is divided into four chapters |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Enhancement of solubility and bioavailability |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glimepiride |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanotechnology |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Abdelbary Abdelrahman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omneya Mohamed Abdelkader , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2016.Mu.E | 01010110069562000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2016.Mu.E | 01020110069562000 | 22.09.2023 | CD - Rom | 69562.CD |