COX-2 expression as a prognostic factor in pediatric hodgkin lymphoma / (Record no. 58465)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03572cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031609.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 161106s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.05.Ph.D.2016.Ah.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Hussein Algammal |
| 245 10 - TITLE STATEMENT | |
| Title | COX-2 expression as a prognostic factor in pediatric hodgkin lymphoma / |
| Statement of responsibility, etc. | Ahmed Hussein Algammal ; Supervised Lobna Mohamed Alamin Shalaby , Mohamed Fawzy Ibrahim Hasan , Asmaa Ibrahim Abdelaziz Salama |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دلالة الكوكس-٢ و أهميته المنزرة فى الأطفال المصابين بسرطان هودجكين الليمفاوى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Hussein Algammal , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 162 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Cyclooxygenase 2 (COX-2) is an inflammatory enzyme and it was proved to have a role in tumorigenesis mechanisms including tumor proliferation, differentiation, immunosupression, angiogenesis and inhibition of apoptosis. It has been demonstrated that COX-2 expression increases in colon, stomach, esophagus, lung, ovary, cervix, liver, pancreas adenocarcinomas and brain tumors as a negative prognostic parameter. Methods: We investigated the prognostic value of COX-2 expression using immunstaining in a group of pediatric Hodgkin lymphoma (HL) patients (n=131), who presented during the period from January 2005 till June 2013, and whose data were retrieved from the medical record of the Pediatric Oncology department, National Cancer Institute, Cairo University and they were followed up till August 2015. Statistical analysis was done, including comparing the most recognized clinical variables in relation to COX-2 expression. Results: Cyclooxygenase 2 was expressed on Reed-Sternberg cells in 37.4% of the whole group. There were no differences in the distribution of prognostic variables according to COX-2 expression. With a mean follow-up period of 54.4 months, 5 year PFS was lower in COX-2+ve than that in COX-2 -ve patients but without statistical significance. The 5 year overall survival was also lower in COX-2 +ve patients than in {u2013}ve ones without statistical significance as well. The major impact on prognosis was observed in male group of patients. With a significantly worse 5 year OS (82.9) in +ve % compared to 100% in COX-2 {u2013}ve patients (P value: 0.045) and tendency for Abstract 2 statistical significant 5 year PFS (75.7% Vs 90.2%) in +ve and {u2013}ve respectively (P value: 0.06). Conclusion: COX-2 was expressed on Reed-Sternberg cells in about one third of HL patients and found to be an unfavorable prognostic factor in males with HL. We conclude that COX-2 is a negative prognostic variable in male HL and might be therapeutic target. However, further studies including larger numbers of HL patients are needed to investigate that COX-2 may be a major prognostic variable in HL. expression. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cyclooxygenase 2 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pediatric hodgkin lymphoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Prognostic factors |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Ibrahim Abdelaziz Salama , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lobna Mohamed Alamin Shalaby , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Fawzy Ibrahim Hasan , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.05.Ph.D.2016.Ah.C | 01010110070183000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.05.Ph.D.2016.Ah.C | 01020110070183000 | 22.09.2023 | CD - Rom | 70183.CD |