Phenotyping and cytokines profiling of myeloid dendritic cells in breast cancer patients / (Record no. 59325)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02917cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031635.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170104s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2016.Ha.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hadeer Hesham Abdelfatah |
| 245 10 - TITLE STATEMENT | |
| Title | Phenotyping and cytokines profiling of myeloid dendritic cells in breast cancer patients / |
| Statement of responsibility, etc. | Hadeer Hesham Abdelfatah ; Supervised Somaya Osman Eldeeb , Mona Mostafa Mohamed , Mohamed Elsayed Elshinawi |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التنميط المظهرى وتعريف السيتوكينات للخلايا الشجيرية النخاعية فى مرضى سرطان الثدى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hadeer Hesham Abdelfatah , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 184 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Dendritic cells (DCs) are the most potent antigen presenting cells (APCs) that have the capability to encounter tumor antigens and migrate to lymph nodes (LNs) to complete their maturation. Tumor growth factor-beta (TGF-Ý) as one of tumor derived factors was shown to play a major role in controlling DCs function. The aim of the present study was to assess the mutual interaction between myeloid DCs (mDCs) and breast cancer cells. Numbers of CD11c+ myeloid DCs (mDCs) were counted in peripheral and axillary tributaries blood of breast cancer patients, isolated by negative selection. Culture media containing mDCs derived factors were used to stimulate breast cancer cell line MDA-MB-231 and MCF-7 utilizing 3D in-vitro tissue culture models. Cytokines profiling of mDCs was done using cytokine antibody array. The results showed reduction in secretory function and count of mDCs. TGF-Ý was more expressed in Breast carcinoma tissue of patients with positive LN metastasis with lower infiltration of CD11c+ cells than negative LN metastasis. Moreover, TGF-Ý treated mDCs was observed with elevated levels of apoptotic mDCs even after LPS stimulation. Axillary-tributaries mDCs induce increase in colony size of breast cancer cell lines. In conclusion, the presented results suggest impairment in breast cancer patient's mDCs function with suggesting TGF-Ý to be a major responsible for mDCs dysfunction. Blocking of TGF-Ý emerge as therapeutic target in breast cancer patients with positive LN metastasis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Axillary-tributaries |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancercells |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TGF-Ý |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Elsayed Elshinawi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Mostafa Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Somaya Osman Eldeeb , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2016.Ha.P | 01010110070652000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2016.Ha.P | 01020110070652000 | 22.09.2023 | CD - Rom | 70652.CD |