Application of nanotechnology for ocular drug delivery / (Record no. 60242)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02906cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031702.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170314s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2016.Ma.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mayssa Abdelhady Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Application of nanotechnology for ocular drug delivery / |
| Statement of responsibility, etc. | Mayssa Abdelhady Mohamed ; Supervised Mahmoud M. Ghorab , Hamed A. Salama |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | إستخدإم التقنية النانومرتية لتوصيل الدواء للعين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mayssa Abdelhady Mohamed , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 150 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Brinzolamide, a carbonic anhaydrase inhibitor, is commercially formulated as a 1% ophthalmic suspension to reduce intraocular pressure (IOP). The commercially available preparation of brinzolamide is Azopt® (Alcon Laboratories, Inc, Ft. Worth, Texas, USA). The most common ocular adverse events on using brinzolamide eye drops are blurred vision (3-8%), ocular discomfort (1.8-5.9%) and eye pain (0.7-4.0%). Other ocular adverse events occurring at an incidence of less than 3% include hyperemia, pruritus, tearing, discharge, blepharitis, keratitis, foreign body sensation, dry eye, conjunctivitis and lid margin crusting. Antiglaucoma agents may be administered topically or systemically for the treatment of elevated IOP. Topical application of drugs has remained the most preferred method due to ease of administration and low cost. Anatomical and physiological barriers hinder drugs from reaching posterior segment of the eye, mainly at choroid and retina. A major fraction of drug following topical administration is lost by lacrimation, tear dilution, nasolacrimal drainage and tear turnover. Such precorneal losses result in very low ocular bioavailability. Typically, less than 5% of the total administrated dose reaches aqueous humor. Therefore, in order to maintain minimum effective concentrations, the agents need to be frequently dosed resulting in poor patient compliance. Topical medications have been also noted to induce long term ocular surface changes which may often cause damage to conjunctival and corneal cells. The deleterious effects of preservatives on the ocular surface are of particular concern for patients with chronic conditions such as glaucoma or keratoconjunctivitis sicca |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Brinzolamide |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanotechnology |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pharmaceutics |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamed Abdelaziz Salama , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Mohamed Ghorab , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2016.Ma.A | 01010110071283000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2016.Ma.A | 01020110071283000 | 22.09.2023 | CD - Rom | 71283.CD |