MARC details
| 000 -LEADER |
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| fixed length control field |
03032cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250223031705.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
170321s2016 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.12.10.M.Sc.2016.Ma.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Mahmoud Aly Mourad Metwally |
| 245 10 - TITLE STATEMENT |
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| Title |
Synthesis and biological evaluation of some New fused heterocyclic azine derivatives / |
| Statement of responsibility, etc. |
Mahmoud Aly Mourad Metwally ; Supervised Magda Ahmed Abdallah , Sobhy Mohamed Gomaa |
| 246 15 - VARYING FORM OF TITLE |
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| Title proper/short title |
تشييد و تقييم النشاط البيولوجى لبعض مشتقات الازين الملتحمة متجاًسة الحلقة الجديدة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mahmoud Aly Mourad Metwally , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
172 P. ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
A new series of pyrido[2',3':4,5] pyrimido [2,1-b][1,3,5] thiadiazinones were prepared by aminomethylation of pyridopyrimidinethione with a variety of primary aromatic amines and formaldehyde solution (37%) through mannich reaction. Also, another series of pyrido[2', 3:4,5] pyrimido [2,1-b] [1,3] thiazinones were synthesized by michael addition reaction of pyridopyrimidinethione to the activated double bond of a number of arylidene malononitrile and ethyl 3-aryl-2-cyanopropenoate. The mechanism of formation of the synthesized compounds was discussed and the assigned structure was established via microanalysis and spectral data (IR, 1HNMR and Mass). In addition, the antitumor activities of the synthesized compounds were investigated and the results revealed that these compounds exhibited promising activities against HepG-2 and MCF-7 cancer cell lines. In the second project: 2-Hydrazinyl-5,7-di-p-tolylpyrido [2,3-d] pyrimidin-4 (3H)-one was prepared and condensed with different aldehydes to give the corresponding hydrazone derivatives. Oxidative cyclization of the latter compounds gave the corresponding pyrido [2,3- d] [1,2,4] triazolo [4,3-a] pyrimidin-5 (1H)-one derivatives. Furthermore, the hydrazinyl compound reacted with benzoyl chloride, triethyl orthoformate, acetyl chloride, ethyl chloroformate and carbon disulphide in alcoholic KOH solution to afford the corresponding pyrido [2,3- d][1,2,4] triazolo [4,3-a]pyrimidinones. The reaction of 2-thioxo-5,7-di-p-tolyl-2,3- dihydropyrido [2,3-d]pyrimidin-4(1H)-one or its 2-methylthio derivative with hydrazonoyl halides in dioxane under reflux, in the presence of triethylamine, yielded the corresponding pyrido 2,3-d 1,2,4triazolo 4,3-a pyrimidinones |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Azine derivatives |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Biological evaluation |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
New fused heterocyclic |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Magda Ahmed Abdallah , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sobhy Mohamed Gomaa , |
| Relator term |
|
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |