Possible protection against a huntington's disease model in Rats by calcium channel blockade / (Record no. 60709)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02580cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031717.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170427s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2016.Ar.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Arwa Sobhy Khalil |
| 245 10 - TITLE STATEMENT | |
| Title | Possible protection against a huntington's disease model in Rats by calcium channel blockade / |
| Statement of responsibility, etc. | Arwa Sobhy Khalil ; Supervised Samira Saleh Mostafa , Noha Nagah Nassar |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | إمكانية الوقاية من مرض هنتنغتون المحدث في الجرذان عن طريق حصر قنوات الكالسيوم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Arwa Sobhy Khalil , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 233 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Huntington{u2019}s disease (HD) is a neurodegenerative disorder characterized by motor, cognitive and psychological symptoms. Noteworthy, the current treatments of HD are symptomatic. The current study investigated the neuroprotective mechanisms of dihydropyridine calcium channel blocker namely nimodipine against 3 nitropropionic acid (3NP)-induced HD model in rats. All rats were screened for motor abnormalities using the open field and rotarod tests. Also, memory impairment and stereotypical behavior were assessed in Morris water maze and open field, respectively. Besides, striatal and cortical contents of succinate dehydrogenase, neurotransmitters, oxidative stress biomarkers, inflammatory markers, survival and apoptotic biomarkers were estimated. In addition, histological and immunohistochemical examination of brain sections were investigated. Exposure to 3NP induces HD like symptoms possibly mediated, in part, via mitochondrial dysfunction, oxidative stress, excitotoxicity, inflammatory reactions in the brain. Nimodipine possesses neuroprotective abilities against HD most likely via a combination of several mechanisms such as calcium channel blockade, decrease in oxidative stress, mitigation of excitotoxicity besides reduction of inflammation and glial activation |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Calcium channels |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Excitotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Huntington{u2019}s |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Nagah Nassar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samira Saleh Mostafa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2016.Ar.P | 01010110070937000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2016.Ar.P | 01020110070937000 | 22.09.2023 | CD - Rom | 70937.CD |