Preparation and evaluation of pH sensitive microparticles for colonic targeting / (Record no. 60886)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03010cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031723.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170514s2016 ua ho f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2016.La.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lamyaa Samir Ahmed Bazan |
| 245 10 - TITLE STATEMENT | |
| Title | Preparation and evaluation of pH sensitive microparticles for colonic targeting / |
| Statement of responsibility, etc. | Lamyaa Samir Ahmed Bazan ; Supervised Sabry Sayed Badawy , Omaima N. Elgazayerly , Ehab Rasmey Bendas |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | صياغة و تقييم جسيمات دقيقة تعتمد على التركيز الهيدروجينى لأستهداف القولون |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Lamyaa Samir Ahmed Bazan , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 124 P. : |
| Other physical details | facsimiles , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Spherical, uniform, smooth surfaced microparticles were successfully produced using emulsification / solvent evaporation process. The microparticles yield from the three polymers was above 80% with no significance difference between the three polymers (p<0.05). The microparticles using the three EUDRAGIT® polymers were capable of encapsulating celecoxib at high efficiency. The highest encapsulation efficiency was for EUDRAGIT® S100 followed by the other two polymers with no real difference between the three polymers. The high encapsulation efficiency and microparticle yield suggested that the process is efficient and economical at this scale. The prepared microparticles of the drug (F3, F6) reduced the inflammation and damage to the colon. This reduction was more when compared to that of the drug suspension and F9.The reduction of colon inflammation induced by acetic acid was really clear with EUDRAGIT® S100 and EUDRAGIT® L100-55 and to lesser extent EUDRAGIT® L100. Celecoxib reduced the severity of colonic injury induced by acetic acid and the prepared microparticles increased and localized the drug effect on the colon. The used LC MS/MS assay was specific and accurate to determine Celecoxib in rat plasma. The results obtained from the pharmacokinetic analysis suggested that the delay in Tmax indicated delayed release and slow release of the drug from the microparticles leading to the localization of the drug at the site of action which is the colon and may affect the extent of drug absorption. There was a clear increase in the bioavailability of celecoxib prepared as microparticles using the three EUDRAGIT® polymers |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Celecoxib |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Colon targeting |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | PH dependent polymers |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ehab Rasmey Bendas , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omaima N. Elgazayerly , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sabry Sayed Badawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2016.La.P | 01010110071666000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2016.La.P | 01020110071666000 | 22.09.2023 | CD - Rom | 71666.CD |