Analytical studies on solifenacin succinate, flavoxate HCl and toltoridine tartarate anti-cholinergic drugs / (Record no. 60924)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02917cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031724.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170516s2016 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.08.M.Sc.2016`.He.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Heba Elsayed Ahmed Attia |
| 245 10 - TITLE STATEMENT | |
| Title | Analytical studies on solifenacin succinate, flavoxate HCl and toltoridine tartarate anti-cholinergic drugs / |
| Statement of responsibility, etc. | Heba Elsayed Ahmed Attia ; Supervised Eman Y. Z. Farag , Ali Kamal Attia |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسات تحليلية على أدوية سوليفيناسين سكسنات و فلافوكسات هيدروكلورايد و تولتورودين ترترات المضادة لنشاط الجهاز العصبى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Heba Elsayed Ahmed Attia , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 92 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | A simple, precise, specific and accurate reversed phase HPLC (RP-HPLC) method has been developed for the determination of solifenacin succinate (SOLS), flavoxate HCl (FLXHC) and toltoridine tartarate (TOLT) in bulk and in pharmaceutical dosage forms. The proposed RP-HPLC method was carried out using Xterra RP-18 column (5 om practical size, 25 cmx4.6 mm i.d.). The flow rate, the injection volume and the detection wavelength were 1.0 mL/min, 20 mL and 200 nm, respectively. The mobile phase consisted of 0.05 M pentane sulfonic acid sodium salt (SOLS: pH 3.0±0.05, FLXHC and TOLT: pH 5.5±0.05) and acetonitrile (50:50 v/v). The retention times for SOLS, FLXHC and TOLT drugs were found to be 4.08±0.06, 4.30±0.03 and 5.85±0.07 min, respectively. The calibration was linear over the concentration range of 0.1-100 ogmL-1. The mean recoveries for SOLS, FLXHC and TOLT drugs were about 99.80, 100.43 and 100.00%, respectively. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness. In this work SOLS, FLXHC and TOLT drugs were investigated using thermal analysis (TA) measurements (TG-DTA) in comparison with electron impact (EI) mass spectral (MS) fragmentation at 70 eV. Also determination of chemical purity, melting range using differential scanning calorimetry (DSC), and variation of enthalpy in the process of characterizing medicines is one of the principal requirements evaluated in quality control of the pharmaceutical industry |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Flavoxate HCl |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Solifenacin succinate |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Toltoridine tartarate anti-cholinergic drugs |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ali Kamal Attia , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Yousry Z. Farag , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.08.M.Sc.2016`.He.A | 01010110071692000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.08.M.Sc.2016`.He.A | 01020110071692000 | 22.09.2023 | CD - Rom | 71692.CD |