Functionalized nanoparticles and their effect on immune response to co-delivered antigen / (Record no. 61170)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03343cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031731.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170611s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.10.Ph.D.2016.Ho.F |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hossam Eldin Mahmoud Abdelhady |
| 245 10 - TITLE STATEMENT | |
| Title | Functionalized nanoparticles and their effect on immune response to co-delivered antigen / |
| Statement of responsibility, etc. | Hossam Eldin Mahmoud Abdelhady ; Supervised Wagih Armanious Gad Elsaid , Mona Ibrahim Elenbaawy , Mahmoud Dardiri Elhariri |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | جزيئات النانو الموظفة و آثارها علي الاستجابة المناعية كناقلة للأنتيجن |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hossam Eldin Mahmoud Abdelhady , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 304 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Microbiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The current study investigated the immunological properties of functionalized nanoparticle as antigen carrier and immune stimulant. Formulated nano- vaccine was positioned to build a protection against chronic respiratory disease (CRD) caused by Mycoplasma gallisepticum (MG) which is frequently complicated by avian pathogenic E. coli (APEC) causing complicated chronic respiratory disease (CCRD). Field strains of MG and APEC were isolated and the latter was the source of outer membrane vesicles (OMVs). Poly (D,L lactide-co-glycolic acid) (PLGA) co-polymer was used as nano-capsule in this study. The first and second components of nano-vaccine were MG protein and DNA, they were both entrapped in PLGA nanocapsule through double emulsion process. The third component was OMVs of APEC. 270 SPF experimental chickens were divided into 6 tested groups and 6 control groups. Three groups were administered the nanovaccine subcutaneously (SC) and compared with killed commercial MG vaccine while other three groups were administered via intraocular route (IO) and compared with F strain. Evaluation of immunizing potency of nano-vaccine was measured by monitoring IgG status of MG with ELISA and estimating protection efficacy from CRD and CCRD after challenge test. It was shown that administration of un-capsulated MG protein failed to stimulate immune response while PLGA capsulated did so, thus it could be inferred that PLGA capsule performed adjuvanting effect. SC administration of booster dose from PLGA- MG proteins achieved (80%) protection from CRD and (70%) without booster. IO administration of PLGA- MG proteins achieved (70 %) protection from CRD. The maximum protection from CRD (90%) was attained in case of SC injection of PLGA -MG protein plus PLGA-DNA. OMVs reduced the incidence of CCRD to (0%) through SC injection provided that the booster dose had been administered |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Co-delivered antigen |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Functionalized nanoparticles |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Immune response |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Dardiri Elhariri , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Ibrahim Elenbaawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wagih Armanious Gad Elsaid , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.10.Ph.D.2016.Ho.F | 01010110071836000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.10.Ph.D.2016.Ho.F | 01020110071836000 | 22.09.2023 | CD - Rom | 71836.CD |