A pharmaceutical study on a central nervous system acting drug for intranasal administration / (Record no. 61177)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03280cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031731.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170611s2016 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2016.Ma.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Marian Joseph Naguib |
| 245 12 - TITLE STATEMENT | |
| Title | A pharmaceutical study on a central nervous system acting drug for intranasal administration / |
| Statement of responsibility, etc. | Marian Joseph Naguib ; Supervised Samia A. Nour , Nevine S. Abdelmalak |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة صيدلية على توصيل عقار يعمل على الجهاز العصبى المركزى عن طريق الانف |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Marian Joseph Naguib , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 169 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study aimed to formulate clonazepam (CZ) as intranasal nanocarriers for immediate control of status epilepticus. Nanocarriers generally have the ability to deliver the drug to the brain through olfactory and trigeminal nerves pathways circumventing the blood brain barrier. Chapter I: Formulation of clonazepam loaded polymeric micelles. A three-level three-factor central composite face-centered design (3³ CCFD) was applied for the preparation using thin film hydration technique. The independent variables were; pluronic® P123 concentration (X₁), Pluronics®: drug ratio (X₂) and hydration volume (X₃). The seventeen prepared formulae were evaluated for: Y₁: entrapment efficiency (%), Y₂: particle size (nm), Y₃: polydispersity index , Y₄: zeta potential (mV), Y₅: cumulative clonazepam released after eight hours (%), Y₆: time for the release of 50% of drug (hr) and Y₇: dissolution efficiency. All the responses except particle size and zeta potential were influenced by the studied variables. Optimization was done by maximizing entrapment efficiency, amount released after eight hours and dissolution efficiency and minimizing polydispersity index and time for the release of 50% drug. The highest desirability value obtained was 0.921 and was denoted to: X₁=50%, X₂=40:1 and X₃=10 ml (formula PM7). Differential scanning calorimetery and transmission electron microscopy demonstrated the ability of the optimized formula to incorporate clonazepam. This formula showed good thermodynamic and kinetic stability when stored for 4 weeks at room temperature. Chapter II: Formulation of clonazepam loaded Transferosomes. Full factorial design (FFD) (2² X 3¹) was adopted for the preparation using thin film hydration technique. The independent variables investigated were X₁: edge activator type (sodium deoxycholate and Labrafil®), X₂: lipid: edge activator molar ratio 10:1, 30:1 and 50:1 and X₃: initial drug amount 10 and 20 mg |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Central nervous system acting |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Formulate clonazepam (CZ) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Intranasal administration |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nevine Shawky Abdelmalak , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samia Abdelkader Nour , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2016.Ma.P | 01010110071823000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2016.Ma.P | 01020110071823000 | 22.09.2023 | CD - Rom | 71823.CD |