Immunohistochemical expression of galectin-1 in chondroblastic osteosarcoma and conventional chonrosarcoma in comparison with normal bone : (Record no. 62174)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03845cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031801.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170829s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.09.13.M.Sc.2016.Al.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ali Abdelwahed Abdelfatah Kotb |
| 245 10 - TITLE STATEMENT | |
| Title | Immunohistochemical expression of galectin-1 in chondroblastic osteosarcoma and conventional chonrosarcoma in comparison with normal bone : |
| Remainder of title | Comparative in-vitro study / |
| Statement of responsibility, etc. | Ali Abdelwahed Abdelfatah Kotb ; Supervised Louloua Mohamed Fathy , Nermine Raouf Amin |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التعبيير المناعى النسيجى الكيميائى لبروتين جالكتين-١ فى السركومة العظمية الغضروفية و السركومة الغضروفية مقارنة مع العظم الطبيعى : |
| Remainder of title | دراسة معملية مقارنة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ali Abdelwahed Abdelfatah Kotb , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 103 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Surgery |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Osteosarcomas and chondrosarcomas are two of the most common types of primary bone malignancies. Osteosarcoma is the most common oral malignancy encountered by oral and maxillofacial pathologists after squamous cell carcinoma. Chondrosarcoma incidence as a primary bone malignancy usually comes following osteosarcoma. Osteosarcoma is a primary bone malignancy of mesenchymal stem cells that produces bone. Its diagnosis is based on the production of osteoid from the malignant cellular stroma. Chondrosarcoma on the other hand, is a malignant neoplasm that arises from mesenchymal cells that undergo partial differentiation to form chondroblastic tissue without osteoid production. Chondroblastic osteosarcoma is a type of osteosarcoma that forms pockets of osteoid in addition to chondroblastic differentiation. Chondroblastic osteosarcoma and chondrosarcoma are two overlapping tumors that are usually misdiagnosed due to the presence of chondroblastic tissue in both of them in addition to the presence of osteoid arising from the malignant stroma in the chondroblastic osteosarcoma. In the absence of a specific diagnostic marker that discriminates accurately between chondoblastic osteosarcoma and chondrosarcoma, misdiagnosis of both tumors might occur. Osteosarcoma treatment usually involves neoadjuvant chemotherapy followed by radical surgery, while chondrosarcoma is usually treated, only, by radical surgical resection. In general chondrosarcoma bears a better prognosis than osteosarcoma. Galectins are a large family of proteins. Only galectin-1, -2, -3, -4, -7, -8, -9, -10, -12 and -13 have been identified in humans. They have a long list of functions. In our study, we were concerned with GAL-1. GAL-1 was expressed in human osteoblasts, suggesting that GAL-1 reactivity might identify tumors of osteoblastic origin. Previous demonstrations showed GAL-1 expression in normal and malignant cells, consequently, this work used GAL-1 as a marker of the osteoblastic lineage rather than a marker of malignancy. In this project, we also analyzed the statistical difference in the immunohistochemical expression of GAL-1 in chondroblastic osteosarcoma and chondrosarcoma to serve as a dicriminitive diagnostic test for both tumors |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chondroblastic osteosarcoma and chondrosarcoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | GAL-1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oral and Maxillofacial Surgery |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Louloua Mohamed Fathy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nermine Raouf Amin , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.09.13.M.Sc.2016.Al.I | 01010110072507000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.09.13.M.Sc.2016.Al.I | 01020110072507000 | 22.09.2023 | CD - Rom | 72507.CD |